Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0745 | 1 | 1 |
Toxoplasma gondii | lactate dehydrogenase LDH2 | 0.0417 | 0.3312 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0403 | 0.3027 | 0.3027 |
Leishmania major | carbonic anhydrase-like protein | 0.0745 | 1 | 1 |
Echinococcus granulosus | lactate dehydrogenase a | 0.0417 | 0.3312 | 0.3312 |
Echinococcus granulosus | L lactate dehydrogenase B chain | 0.0417 | 0.3312 | 0.3312 |
Plasmodium vivax | malate dehydrogenase, putative | 0.0417 | 0.3312 | 0.5 |
Echinococcus multilocularis | L lactate dehydrogenase B chain | 0.0417 | 0.3312 | 0.3312 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0417 | 0.3312 | 0.3312 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0745 | 1 | 0.5 |
Brugia malayi | lactate dehydrogenase. | 0.0417 | 0.3312 | 0.0409 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0417 | 0.3312 | 0.3312 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0745 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0403 | 0.3027 | 0.3027 |
Schistosoma mansoni | L-lactate dehydrogenase | 0.0417 | 0.3312 | 0.0409 |
Echinococcus granulosus | carbonic anhydrase II | 0.0745 | 1 | 1 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0417 | 0.3312 | 0.3312 |
Echinococcus granulosus | lactate dehydrogenase a | 0.0417 | 0.3312 | 0.3312 |
Plasmodium falciparum | L-lactate dehydrogenase | 0.0417 | 0.3312 | 1 |
Echinococcus multilocularis | lactate dehydrogenase protein | 0.0417 | 0.3312 | 0.3312 |
Echinococcus multilocularis | carbonic anhydrase | 0.0403 | 0.3027 | 0.3027 |
Toxoplasma gondii | malate dehydrogenase MDH | 0.0417 | 0.3312 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0403 | 0.3027 | 0.3027 |
Toxoplasma gondii | lactate dehydrogenase LDH1 | 0.0417 | 0.3312 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0403 | 0.3027 | 0.3027 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0745 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0403 | 0.3027 | 0.3027 |
Plasmodium vivax | lactate dehydrogenase | 0.0417 | 0.3312 | 0.5 |
Schistosoma mansoni | malate dehydrogenase | 0.0417 | 0.3312 | 0.0409 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0745 | 1 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0745 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0745 | 1 | 1 |
Entamoeba histolytica | malate dehydrogenase, putative | 0.0417 | 0.3312 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.3312 | 0.0409 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0745 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | malate dehydrogenase | 0.0417 | 0.3312 | 0.5 |
Plasmodium falciparum | malate dehydrogenase | 0.0417 | 0.3312 | 1 |
Echinococcus granulosus | lactate dehydrogenase protein | 0.0417 | 0.3312 | 0.3312 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0745 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 25 ug ml-1 | Antitubercular activity against multidrug-resistant Mycobacterium tuberculosis after 6 weeks | ChEMBL. | No reference |
MIC (functional) | = 25 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv after 6 weeks | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.