Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0845 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | malate dehydrogenase | 0.0473 | 0.3312 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0845 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0458 | 0.3027 | 0.3027 |
Plasmodium vivax | lactate dehydrogenase | 0.0473 | 0.3312 | 0.5 |
Toxoplasma gondii | lactate dehydrogenase LDH2 | 0.0473 | 0.3312 | 1 |
Schistosoma mansoni | L-lactate dehydrogenase | 0.0473 | 0.3312 | 0.0409 |
Echinococcus multilocularis | carbonic anhydrase | 0.0458 | 0.3027 | 0.3027 |
Echinococcus multilocularis | carbonic anhydrase | 0.0458 | 0.3027 | 0.3027 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0473 | 0.3312 | 0.3312 |
Echinococcus multilocularis | carbonic anhydrase | 0.0458 | 0.3027 | 0.3027 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0845 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0845 | 1 | 1 |
Echinococcus granulosus | lactate dehydrogenase protein | 0.0473 | 0.3312 | 0.3312 |
Echinococcus multilocularis | lactate dehydrogenase protein | 0.0473 | 0.3312 | 0.3312 |
Schistosoma mansoni | malate dehydrogenase | 0.0473 | 0.3312 | 0.0409 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0845 | 1 | 0.5 |
Toxoplasma gondii | malate dehydrogenase MDH | 0.0473 | 0.3312 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0845 | 1 | 1 |
Brugia malayi | lactate dehydrogenase. | 0.0473 | 0.3312 | 0.0409 |
Echinococcus granulosus | carbonic anhydrase | 0.0458 | 0.3027 | 0.3027 |
Echinococcus granulosus | carbonic anhydrase | 0.0458 | 0.3027 | 0.3027 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0473 | 0.3312 | 0.3312 |
Echinococcus multilocularis | L lactate dehydrogenase B chain | 0.0473 | 0.3312 | 0.3312 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0845 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0845 | 1 | 1 |
Echinococcus granulosus | lactate dehydrogenase a | 0.0473 | 0.3312 | 0.3312 |
Plasmodium vivax | malate dehydrogenase, putative | 0.0473 | 0.3312 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0845 | 1 | 1 |
Plasmodium falciparum | malate dehydrogenase | 0.0473 | 0.3312 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0845 | 1 | 1 |
Echinococcus granulosus | L lactate dehydrogenase B chain | 0.0473 | 0.3312 | 0.3312 |
Echinococcus granulosus | lactate dehydrogenase a | 0.0473 | 0.3312 | 0.3312 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0473 | 0.3312 | 0.3312 |
Entamoeba histolytica | malate dehydrogenase, putative | 0.0473 | 0.3312 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0845 | 1 | 1 |
Toxoplasma gondii | lactate dehydrogenase LDH1 | 0.0473 | 0.3312 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0473 | 0.3312 | 0.0409 |
Plasmodium falciparum | L-lactate dehydrogenase | 0.0473 | 0.3312 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 6.25 ug ml-1 | Antitubercular activity against multidrug-resistant Mycobacterium tuberculosis after 6 weeks | ChEMBL. | No reference |
MIC (functional) | = 12.5 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv after 6 weeks | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.