Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Hormone-sensitive lipase | Starlite/ChEMBL | References |
Homo sapiens | lipase, hormone-sensitive | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.2456 | 0.2345 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0308 | 0.4061 | 0.2863 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0308 | 0.4061 | 0.2863 |
Echinococcus granulosus | histone deacetylase 3 | 0.0254 | 0.2456 | 0.0934 |
Trypanosoma brucei | histone deacetylase 1 | 0.0254 | 0.2456 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0254 | 0.2456 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0228 | 0.1679 | 0.1557 |
Leishmania major | histone deacetylase, putative | 0.0254 | 0.2456 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0254 | 0.2456 | 1 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0506 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 1 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0254 | 0.2456 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0254 | 0.2456 | 0.2345 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0254 | 0.2456 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0308 | 0.4061 | 0.2863 |
Echinococcus multilocularis | serotonin receptor | 0.0308 | 0.4061 | 0.2863 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0254 | 0.2456 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0228 | 0.1679 | 0.6638 |
Schistosoma mansoni | amine GPCR | 0.0388 | 0.6457 | 0.5742 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0254 | 0.2456 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0254 | 0.2456 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0254 | 0.2456 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0254 | 0.2456 | 0.0934 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0254 | 0.2456 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0254 | 0.2456 | 0.2345 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.4061 | 0.3974 |
Plasmodium falciparum | histone deacetylase 1 | 0.0254 | 0.2456 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0254 | 0.2456 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0241 | 0.207 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.4061 | 0.3974 |
Schistosoma mansoni | histone deacetylase | 0.0254 | 0.2456 | 0.0934 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0254 | 0.2456 | 0.0934 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0241 | 0.207 | 0.047 |
Giardia lamblia | Histone deacetylase | 0.0254 | 0.2456 | 0.5 |
Echinococcus granulosus | histone deacetylase 1 | 0.0254 | 0.2456 | 0.0934 |
Echinococcus granulosus | histone deacetylase 6 | 0.0241 | 0.207 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0254 | 0.2456 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0254 | 0.2456 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0254 | 0.2456 | 0.0934 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0254 | 0.2456 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0254 | 0.2456 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0254 | 0.2456 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0254 | 0.2456 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.0254 | 0.2456 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0228 | 0.1679 | 0.1557 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0254 | 0.2456 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0228 | 0.1679 | 0.6638 |
Leishmania major | histone deacetylase, putative | 0.0254 | 0.2456 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1000 nM | Inhibition of human recombinant hormone sensitive lipase (HSL) | ChEMBL. | 15149665 |
IC50 (functional) | > 1000 nM | Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells | ChEMBL. | 15149665 |
IC50 (binding) | > 1000 nM | Inhibition of human recombinant hormone sensitive lipase (HSL) | ChEMBL. | 15149665 |
IC50 (functional) | > 1000 nM | Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells | ChEMBL. | 15149665 |
IC50 (binding) | > 1000 nM | Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay | ChEMBL. | 18808096 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.