Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | spleen tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tyrosine protein kinase shark | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma mansoni | tyrosine kinase | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma mansoni | tyrosine kinase | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma japonicum | ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma japonicum | ko:K05855 spleen tyrosine kinase, putative | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Echinococcus multilocularis | tyrosine protein kinase shark | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cyclin B | 0.031 | 0.0203 | 0.0095 |
Schistosoma mansoni | tyrosine kinase | 0.0258 | 0.0143 | 0.0034 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0264 | 0.015 | 0.0041 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.031 | 0.0203 | 0.5 |
Trypanosoma brucei | mitotic cyclin 6 | 0.031 | 0.0203 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.031 | 0.0203 | 1 |
Onchocerca volvulus | 0.031 | 0.0203 | 0.5 | |
Trypanosoma cruzi | cyclin, putative | 0.031 | 0.0203 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.031 | 0.0203 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0229 | 0.0109 | 0.539 |
Leishmania major | cyclin | 0.031 | 0.0203 | 0.5 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.031 | 0.0203 | 0.5 |
Loa Loa (eye worm) | hyaluronidase | 0.871 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.031 | 0.0203 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0229 | 0.0109 | 0.539 |
Echinococcus multilocularis | cyclin B | 0.031 | 0.0203 | 0.0095 |
Trichomonas vaginalis | cyclin A, putative | 0.031 | 0.0203 | 1 |
Schistosoma mansoni | Hyaluronidase | 0.871 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.031 | 0.0203 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0174 | 0.0045 | 0.5 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0589 | 0.0529 | 0.0424 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0589 | 0.0529 | 0.0332 |
Trichomonas vaginalis | cyclin D, putative | 0.0229 | 0.0109 | 0.539 |
Trichomonas vaginalis | cyclin B, putative | 0.031 | 0.0203 | 1 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0589 | 0.0529 | 0.0424 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.871 | 1 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.031 | 0.0203 | 0.5 |
Trichomonas vaginalis | cyclin D, putative | 0.0229 | 0.0109 | 0.539 |
Loa Loa (eye worm) | hypothetical protein | 0.37 | 0.4157 | 0.4036 |
Trypanosoma cruzi | cyclin 6, putative | 0.031 | 0.0203 | 0.5 |
Entamoeba histolytica | cyclin, putative | 0.031 | 0.0203 | 1 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.871 | 1 | 1 |
Plasmodium falciparum | cyclin | 0.0229 | 0.0109 | 0.5 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.031 | 0.0203 | 1 |
Schistosoma mansoni | cyclin B3 | 0.0589 | 0.0529 | 0.0424 |
Echinococcus granulosus | cyclin B | 0.031 | 0.0203 | 0.0095 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.871 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0264 | 0.015 | 0.0041 |
Trichomonas vaginalis | cyclins, putative | 0.031 | 0.0203 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.031 | 0.0203 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0264 | 0.015 | 0.0041 |
Trichomonas vaginalis | cyclin B3, putative | 0.0229 | 0.0109 | 0.539 |
Trichomonas vaginalis | cyclins, putative | 0.0229 | 0.0109 | 0.539 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0589 | 0.0529 | 0.0332 |
Trichomonas vaginalis | cyclins, putative | 0.031 | 0.0203 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.937 uM | Inhibition of spleen tyrosine kinase (unknown origin) | ChEMBL. | 23917087 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.