Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Hormone-sensitive lipase | Starlite/ChEMBL | References |
Homo sapiens | lipase, hormone-sensitive | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 nM | Evaluated for the inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells; Na = Not active | ChEMBL. | 15149665 |
IC50 (binding) | > 1000 nM | Inhibition of human recombinant hormone sensitive lipase (HSL) | ChEMBL. | 15149665 |
IC50 (binding) | > 1000 nM | Inhibition of human recombinant hormone sensitive lipase (HSL) | ChEMBL. | 15149665 |
IC50 (binding) | > 1000 nM | Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay | ChEMBL. | 18808096 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.