Detailed information for compound 17919

Basic information

Technical information
  • TDR Targets ID: 17919
  • Name: (3S)-4-[[(1S)-1-cyclohexyl-2-hydroxy-2-oxoeth yl]amino]-3-[[2-[(4S)-4-[3-(diaminomethyliden eamino)propyl]-2,5-dioxoimidazolidin-1-yl]ace tyl]amino]-4-oxobutanoic acid
  • MW: 511.529 | Formula: C21H33N7O8
  • H donors: 7 H acceptors: 8 LogP: -1.06 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 3
  • SMILES: O=C(CN1C(=O)N[C@H](C1=O)CCCNC(=N)N)N[C@H](C(=O)N[C@@H](C1CCCCC1)C(=O)O)CC(=O)O
  • InChi: 1S/C21H33N7O8/c22-20(23)24-8-4-7-12-18(33)28(21(36)26-12)10-14(29)25-13(9-15(30)31)17(32)27-16(19(34)35)11-5-2-1-3-6-11/h11-13,16H,1-10H2,(H,25,29)(H,26,36)(H,27,32)(H,30,31)(H,34,35)(H4,22,23,24)/t12-,13-,16-/m0/s1
  • InChiKey: OGHZJFJHQUJXSE-XEZPLFJOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3S)-4-[[(1S)-1-cyclohexyl-2-hydroxy-2-oxo-ethyl]amino]-3-[[2-[(4S)-4-(3-guanidinopropyl)-2,5-dioxo-imidazolidin-1-yl]acetyl]amino]-4-oxo-butanoic acid
  • (3S)-4-[[(1S)-1-cyclohexyl-2-hydroxy-2-oxoethyl]amino]-3-[[2-[(4S)-4-(3-guanidinopropyl)-2,5-dioxo-1-imidazolidinyl]-1-oxoethyl]amino]-4-oxobutanoic acid
  • (3S)-3-[2-[(4S)-4-[3-[bis(azanyl)methylideneamino]propyl]-2,5-dioxo-imidazolidin-1-yl]ethanoylamino]-4-[[(1S)-1-cyclohexyl-2-hydroxy-2-oxo-ethyl]amino]-4-oxo-butanoic acid
  • (3S)-4-[[(1S)-1-cyclohexyl-2-hydroxy-2-keto-ethyl]amino]-3-[[2-[(4S)-4-(3-guanidinopropyl)-2,5-diketo-imidazolidin-1-yl]acetyl]amino]-4-keto-butyric acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide receptor 0.0076 0.2281 0.2281
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0076 0.2281 0.2281
Echinococcus multilocularis somatostatin receptor 0.0076 0.2281 0.2112
Onchocerca volvulus 0.0076 0.2281 1
Echinococcus granulosus fmrfamide receptor 0.0076 0.2281 0.2281
Onchocerca volvulus 0.0024 0.0214 0.094
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0076 0.2281 0.2281
Onchocerca volvulus 0.0076 0.2281 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.2281 0.2281
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0076 0.2281 0.2112
Brugia malayi Cathepsin L-like precursor 0.0024 0.0214 0.0214
Onchocerca volvulus 0.0024 0.0214 0.094
Echinococcus multilocularis neuropeptide receptor A26 0.0076 0.2281 0.2112
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0076 0.2281 0.2281
Brugia malayi G protein-coupled receptor 0.0076 0.2281 0.2281
Onchocerca volvulus 0.0076 0.2281 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.2281 0.2281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.2281 0.2281
Onchocerca volvulus 0.0076 0.2281 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.1821 0.1642
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0076 0.2281 0.2112
Schistosoma mansoni hypothetical protein 0.0076 0.2281 0.2281
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0083 0.2575 0.2412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0214 0.0745
Onchocerca volvulus 0.0024 0.0214 0.094
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0214 0.0745
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0076 0.2281 0.2281
Echinococcus multilocularis G protein coupled receptor 139 0.0076 0.2281 0.2112
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Echinococcus granulosus dro:myosuppressin receptor 0.0076 0.2281 0.2281
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0076 0.2281 0.2281
Schistosoma mansoni amine GPCR 0.0076 0.2281 0.2281
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0269 1 1
Onchocerca volvulus 0.0076 0.2281 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0076 0.2281 0.2112
Brugia malayi neuropeptide F receptor 0.0076 0.2281 0.2281
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0214 0.0745
Echinococcus multilocularis neuropeptide s receptor 0.0076 0.2281 0.2112
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0214 0.0745
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Echinococcus granulosus neuropeptide receptor 0.0076 0.2281 0.2281
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.2281 0.2281
Echinococcus granulosus tachykinin peptides receptor 99D 0.0076 0.2281 0.2281
Echinococcus granulosus 7TM GPCR rhodopsin 0.0076 0.2281 0.2281
Loa Loa (eye worm) G-protein coupled receptor 0.0076 0.2281 0.2281
Onchocerca volvulus 0.0076 0.2281 1
Brugia malayi putative neuropeptide receptor NPR1 0.0076 0.2281 0.2281
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0024 0.0214 0.0214
Echinococcus multilocularis serotonin receptor 0.0076 0.2281 0.2112
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0091 0.2876 0.272
Echinococcus multilocularis sex peptide receptor 0.0076 0.2281 0.2112
Echinococcus multilocularis neuropeptide receptor 0.0076 0.2281 0.2112
Schistosoma mansoni opsin-like receptor 0.0076 0.2281 0.2281
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0076 0.2281 0.2281
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.2281 0.2112
Brugia malayi hypothetical protein 0.0076 0.2281 0.2281
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0076 0.2281 0.2112
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0076 0.2281 0.2112
Echinococcus granulosus neuropeptide receptor A26 0.0076 0.2281 0.2281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.2281 0.2281
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0076 0.2281 0.2281
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0113 0.3764 0.3764
Brugia malayi RE15519p 0.0076 0.2281 0.2281
Echinococcus granulosus cathepsin b 0.0269 1 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Onchocerca volvulus 0.0024 0.0214 0.094
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0076 0.2281 0.2281
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0269 1 1
Brugia malayi G-protein coupled receptor 0.0076 0.2281 0.2281
Onchocerca volvulus 0.0076 0.2281 1
Schistosoma mansoni amine GPCR 0.0076 0.2281 0.2281
Echinococcus granulosus allatostatin A receptor 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0122 0.4137 0.4137
Brugia malayi hypothetical protein 0.0076 0.2281 0.2281
Loa Loa (eye worm) neuropeptide F receptor 0.0076 0.2281 0.2281
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.2281 0.2112
Echinococcus multilocularis fmrfamide receptor 0.0076 0.2281 0.2112
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.2281 0.2281
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0076 0.2281 0.2112
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Brugia malayi Tachykinin-like peptides receptor 99D 0.0076 0.2281 0.2281
Schistosoma mansoni neuropeptide f receptor 76f 0.0076 0.2281 0.2281
Echinococcus granulosus neuropeptide Y receptor 0.0076 0.2281 0.2281
Loa Loa (eye worm) glutamate receptor 0.0039 0.081 0.081
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0214 0.0745
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.2281 0.2112
Onchocerca volvulus Cathepsin F homolog 0.0024 0.0214 0.094
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0269 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.2281 0.2112
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0076 0.2281 0.2281
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0076 0.2281 0.2112
Brugia malayi hypothetical protein 0.0076 0.2281 0.2281
Toxoplasma gondii cathepsin B 0.0091 0.2876 1
Schistosoma mansoni metabotropic glutamate receptor 0.0048 0.1183 0.1183
Brugia malayi Receptor family ligand binding region containing protein 0.0025 0.0265 0.0265
Loa Loa (eye worm) cathepsin B 0.0091 0.2876 0.2876
Brugia malayi hypothetical protein 0.0076 0.2281 0.2281
Trypanosoma brucei cysteine peptidase C (CPC) 0.0091 0.2876 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0025 0.0265 0.0265
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0076 0.2281 0.2281
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0269 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0214 0.0745
Schistosoma mansoni neuropeptide receptor 0.0076 0.2281 0.2281
Schistosoma mansoni biogenic amine (5HT) receptor 0.0076 0.2281 0.2281
Echinococcus granulosus serotonin receptor 0.0076 0.2281 0.2281
Schistosoma mansoni metabotropic glutamate receptor 0.0083 0.2575 0.2575
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0214 0.0745
Entamoeba histolytica cysteine protease, putative 0.0024 0.0214 1
Onchocerca volvulus 0.0024 0.0214 0.094
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0076 0.2281 0.2281
Brugia malayi G protein-coupled receptor F59B2.13 0.0076 0.2281 0.2281
Echinococcus multilocularis cathepsin b 0.0269 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0076 0.2281 0.2112
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.2036 0.1861
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.2036 0.1861
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.2281 0.2281
Leishmania major cathepsin L-like protease 0.007 0.2036 0.6844
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.2281 0.2281
Brugia malayi Cathepsin L-like precursor 0.0024 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0122 0.4137 0.4009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0214 0.0745
Brugia malayi neuropeptide F receptor 0.0076 0.2281 0.2281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0214 0.0745
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0214 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0214 0.0745
Echinococcus granulosus orexin receptor type 2 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.2281 0.2281
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.2281 0.2281
Brugia malayi Dopamine receptor protein 2 0.0076 0.2281 0.2281
Echinococcus granulosus peptide allatostatin:somatostatin 0.0076 0.2281 0.2281
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0076 0.2281 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Brugia malayi hypothetical protein 0.0076 0.2281 0.2281
Echinococcus multilocularis cathepsin b 0.0269 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0076 0.2281 0.2281
Echinococcus granulosus neuropeptide s receptor 0.0076 0.2281 0.2281
Brugia malayi hypothetical protein 0.0076 0.2281 0.2281
Schistosoma mansoni opsin-like receptor 0.0076 0.2281 0.2281
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0076 0.2281 0.2281
Echinococcus granulosus biogenic amine 5HT receptor 0.0076 0.2281 0.2281
Echinococcus multilocularis G-protein coupled receptor, putative 0.0076 0.2281 0.2112
Brugia malayi Serotonin receptor 0.0076 0.2281 0.2281
Echinococcus granulosus cathepsin L cysteine proteinase 0.0024 0.0214 0.0214
Brugia malayi hypothetical protein 0.0076 0.2281 0.2281
Onchocerca volvulus 0.0024 0.0214 0.094
Loa Loa (eye worm) TYRA-2 protein 0.0076 0.2281 0.2281
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0076 0.2281 0.2281
Brugia malayi ORL1-like opioid receptor 0.0076 0.2281 0.2281
Brugia malayi G-protein coupled receptor 0.0076 0.2281 0.2281
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0076 0.2281 0.2281
Echinococcus granulosus somatostatin receptor 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Schistosoma mansoni growth hormone secretagogue receptor 0.0076 0.2281 0.2281
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.2281 0.2112
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0024 0.0214 0.5
Onchocerca volvulus 0.0076 0.2281 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0214 0.0745
Brugia malayi Metabotropic glutamate receptor precursor. 0.0099 0.3219 0.3219
Brugia malayi hypothetical protein 0.0076 0.2281 0.2281
Schistosoma mansoni neuropeptide receptor 0.0076 0.2281 0.2281
Loa Loa (eye worm) cysteine protease 0.0024 0.0214 0.0214
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.2281 0.2281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0076 0.2281 0.2112
Onchocerca volvulus Cathepsin L homolog 0.0024 0.0214 0.094
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Schistosoma mansoni opsin-like receptor 0.0076 0.2281 0.2281
Brugia malayi Dopamine receptor 0.0076 0.2281 0.2281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0214 0.0745
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0076 0.2281 0.2281
Brugia malayi Cathepsin L-like precursor 0.0024 0.0214 0.0214
Loa Loa (eye worm) neuropeptide F receptor 0.0076 0.2281 0.2281
Giardia lamblia Cathepsin B precursor 0.0091 0.2876 0.5
Schistosoma mansoni hypothetical protein 0.0076 0.2281 0.2281
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0076 0.2281 0.2281
Onchocerca volvulus 0.0076 0.2281 1
Echinococcus granulosus g protein coupled receptor 0.0076 0.2281 0.2281
Schistosoma mansoni adenoreceptor 0.0076 0.2281 0.2281
Schistosoma mansoni biogenic amine receptor 0.0076 0.2281 0.2281
Onchocerca volvulus 0.0076 0.2281 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Onchocerca volvulus Neuropeptide F receptor homolog 0.0076 0.2281 1
Onchocerca volvulus 0.0076 0.2281 1
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.2281 0.2281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0214 0.0745
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0076 0.2281 0.2281
Echinococcus granulosus G protein coupled receptor 139 0.0076 0.2281 0.2281
Onchocerca volvulus 0.0076 0.2281 1
Leishmania major cathepsin L-like protease 0.007 0.2036 0.6844
Echinococcus multilocularis neuropeptide Y receptor 0.0076 0.2281 0.2112
Echinococcus multilocularis neuropeptide Y receptor 0.0076 0.2281 0.2112
Echinococcus granulosus metabotropic glutamate receptor 2 0.0083 0.2575 0.2575
Echinococcus multilocularis g protein coupled receptor 0.0076 0.2281 0.2112
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.2281 0.2281
Echinococcus multilocularis neuropeptides capa receptor 0.0076 0.2281 0.2112
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0024 0.0214 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.2281 0.2281
Echinococcus multilocularis orexin receptor type 2 0.0076 0.2281 0.2112
Loa Loa (eye worm) hypothetical protein 0.0025 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Echinococcus granulosus g protein coupled receptor 0.0076 0.2281 0.2281
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0076 0.2281 0.2112
Onchocerca volvulus 0.0076 0.2281 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0214 0.0745
Onchocerca volvulus 0.0076 0.2281 1
Schistosoma mansoni neuropeptide receptor 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Brugia malayi GnHR receptor homolog 0.0076 0.2281 0.2281
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.2281 0.2112
Echinococcus granulosus neuropeptide Y receptor 0.0076 0.2281 0.2281
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0025 0.0265 0.0265
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.1507 0.1321
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Leishmania major cathepsin L-like protease 0.007 0.2036 0.6844
Schistosoma mansoni hypothetical protein 0.0076 0.2281 0.2281
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.2281 0.2112
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0214 1
Plasmodium vivax vivapain-2 0.0024 0.0214 0.5
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Brugia malayi hypothetical protein 0.0076 0.2281 0.2281
Loa Loa (eye worm) fibroinase 0.0024 0.0214 0.0214
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.2281 0.2281
Brugia malayi hypothetical protein 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0269 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0076 0.2281 0.2281
Loa Loa (eye worm) melatonin receptor type 1A 0.0076 0.2281 0.2281
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0214 0.0745
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0214 0.0745
Brugia malayi sulfakinin receptor protein 0.0076 0.2281 0.2281
Onchocerca volvulus 0.0076 0.2281 1
Brugia malayi larval opioid receptor 0.0076 0.2281 0.2281
Echinococcus multilocularis allatostatin A receptor 0.0076 0.2281 0.2112
Loa Loa (eye worm) hypothetical protein 0.0024 0.0214 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0024 0.0214 0.0745
Brugia malayi Cathepsin L-like precursor 0.0024 0.0214 0.0214
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0076 0.2281 0.2281
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0076 0.2281 0.2281
Echinococcus granulosus g protein coupled receptor 0.0076 0.2281 0.2281
Echinococcus granulosus cathepsin b 0.0269 1 1
Brugia malayi Dopamine receptor protein 1 0.0076 0.2281 0.2281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.2281 0.2281
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0076 0.2281 0.2281
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.0214 0.0214
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0076 0.2281 0.2281
Brugia malayi Cathepsin L-like precursor 0.0024 0.0214 0.0214
Brugia malayi AKH receptor 0.0076 0.2281 0.2281
Schistosoma mansoni alpha-1 adrenergic receptor 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0024 0.0214 0.0745
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0091 0.2876 1
Loa Loa (eye worm) G-protein coupled receptor 0.0076 0.2281 0.2281
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0091 0.2876 0.2876
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.2281 0.2281
Echinococcus multilocularis neuropeptide receptor 0.0076 0.2281 0.2112
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Echinococcus granulosus sex peptide receptor 0.0076 0.2281 0.2281
Schistosoma mansoni hypothetical protein 0.0076 0.2281 0.2281
Brugia malayi Cathepsin L-like precursor 0.0024 0.0214 0.0214
Echinococcus multilocularis fmrfamide receptor 0.0076 0.2281 0.2112
Echinococcus granulosus cathepsin l cysteine peptidase 0.0024 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Schistosoma mansoni amine GPCR 0.0076 0.2281 0.2281
Echinococcus granulosus neuropeptides capa receptor 0.0076 0.2281 0.2281
Echinococcus granulosus neuropeptides capa receptor 0.0076 0.2281 0.2281
Echinococcus granulosus cathepsin l1 0.0024 0.0214 0.0214
Brugia malayi metabotropic glutamate receptor type 2 0.0048 0.1183 0.1183
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Giardia lamblia Cathepsin B precursor 0.0091 0.2876 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0076 0.2281 0.2281
Giardia lamblia Cathepsin B precursor 0.0091 0.2876 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0076 0.2281 0.2281
Schistosoma mansoni biogenic amine receptor 0.0076 0.2281 0.2281
Echinococcus multilocularis neuropeptide FF receptor 2 0.0076 0.2281 0.2112
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.2281 0.2112
Echinococcus granulosus g-protein coupled receptor 0.0076 0.2281 0.2281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0214 0.0745
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0214 0.0745
Echinococcus granulosus neuropeptide FF receptor 2 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Echinococcus multilocularis g protein coupled receptor 0.0076 0.2281 0.2112
Schistosoma mansoni histamine h1 receptor 0.0076 0.2281 0.2281
Onchocerca volvulus Cathepsin L homolog 0.0024 0.0214 0.094
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.2036 0.1861
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0024 0.0214 0.0214
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0214 0.0745
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0076 0.2281 0.2112
Schistosoma mansoni neuropeptide receptor 0.0076 0.2281 0.2281
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.2281 0.2112
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0076 0.2281 0.2112
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.2281 0.2281
Echinococcus multilocularis neuropeptides capa receptor 0.0076 0.2281 0.2112
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Brugia malayi follicle stimulating hormone receptor 0.0076 0.2281 0.2281
Onchocerca volvulus 0.0076 0.2281 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Schistosoma mansoni biogenic amine (5HT) receptor 0.0076 0.2281 0.2281
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.009 0.2846 0.2846
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0269 1 1
Plasmodium vivax vivapain-2 0.0024 0.0214 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0214 0.0745
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Echinococcus granulosus 7tm_1 domain containing protein 0.0076 0.2281 0.2281
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0214 0.0214
Onchocerca volvulus 0.0076 0.2281 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0024 0.0214 0.5
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Echinococcus granulosus hypothetical protein 0.0076 0.2281 0.2281
Loa Loa (eye worm) ctsf protein 0.0024 0.0214 0.0214
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.2036 0.1861
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.2281 0.2112
Brugia malayi Melatonin receptor type 1A 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Echinococcus multilocularis serotonin receptor 0.0076 0.2281 0.2112
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0214 0.0745
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0214 0.0745
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0076 0.2281 0.2281
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Schistosoma mansoni amine GPCR 0.0076 0.2281 0.2281
Schistosoma mansoni biogenic amine receptor 0.0076 0.2281 0.2281
Schistosoma mansoni amine GPCR 0.0076 0.2281 0.2281
Loa Loa (eye worm) glutamate receptor 0.0099 0.3219 0.3219
Brugia malayi putative neuropeptide receptor 0.0076 0.2281 0.2281
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.2281 0.2112
Onchocerca volvulus 0.0024 0.0214 0.094
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0091 0.2876 1
Brugia malayi Serotonin receptor 0.0076 0.2281 0.2281
Schistosoma mansoni myosin xvIII 0.0076 0.2281 0.2281
Echinococcus multilocularis g protein coupled receptor 0.0076 0.2281 0.2112
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281
Echinococcus multilocularis g-protein coupled receptor 0.0076 0.2281 0.2112
Echinococcus granulosus metabotropic glutamate receptor 5 0.0122 0.4137 0.4137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0214 0.0745
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.2281 0.2281
Schistosoma mansoni neuropeptide F-like receptor 0.0076 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0076 0.2281 0.2281

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.5 uM Inhibition of human platelet (isolated from PRP) aggregation ChEMBL. 11312916
IC50 (functional) = 1.5 uM Inhibition of human platelet (isolated from PRP) aggregation ChEMBL. 11312916

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 11312916

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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