Detailed information for compound 179590

Basic information

Technical information
  • TDR Targets ID: 179590
  • Name: ethyl 6-cyclobutyl-4-ethyl-5-ethylsulfanylcar bonyl-2-phenylpyridine-3-carboxylate
  • MW: 397.53 | Formula: C23H27NO3S
  • H donors: 0 H acceptors: 3 LogP: 5.41 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(nc(c(c1CC)C(=O)SCC)C1CCC1)c1ccccc1
  • InChi: 1S/C23H27NO3S/c1-4-17-18(22(25)27-5-2)20(15-11-8-7-9-12-15)24-21(16-13-10-14-16)19(17)23(26)28-6-3/h7-9,11-12,16H,4-6,10,13-14H2,1-3H3
  • InChiKey: QZHIEJZCKKMBAV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ethyl 6-cyclobutyl-4-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-pyridine-3-carboxylate
  • 6-cyclobutyl-4-ethyl-5-[(ethylthio)-oxomethyl]-2-phenyl-3-pyridinecarboxylic acid ethyl ester
  • 6-cyclobutyl-4-ethyl-5-(ethylthio)carbonyl-2-phenyl-nicotin ethyl ester
  • 6-cyclobutyl-4-ethyl-5-(ethylthio)carbonyl-2-phenyl-nicotinic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cyclins, putative 0.009 0.4996 1
Trypanosoma cruzi mitotic cyclin, putative 0.0022 0.1017 0.0787
Trypanosoma brucei Silent information regulator 2 related protein 3 0.005 0.2654 0.4577
Schistosoma mansoni cyclin G 0.0022 0.1017 0.1017
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.1017 0.1547
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0022 0.1017 0.0787
Trichomonas vaginalis cyclins, putative 0.009 0.4996 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.005 0.2654 0.5172
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0677 0.0838
Trypanosoma cruzi cyclin 9, putative 0.0022 0.1017 0.0787
Echinococcus granulosus cpg binding protein 0.0032 0.1587 0.1431
Trichomonas vaginalis cyclins, putative 0.0022 0.1017 0.1798
Schistosoma mansoni chromatin regulatory protein sir2 0.005 0.2654 0.2654
Brugia malayi Cyclin C 0.0022 0.1017 0.1559
Echinococcus granulosus G2:mitotic specific cyclin B3 0.009 0.4996 0.4903
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.1017 0.1559
Trypanosoma brucei cyclin 9 0.0022 0.1017 0.0787
Echinococcus granulosus cyclins 0.009 0.4996 0.4903
Trichomonas vaginalis cyclin D, putative 0.009 0.4996 1
Loa Loa (eye worm) sirtuin 4 0.0016 0.0677 0.0825
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.1017 0.1547
Echinococcus multilocularis cyclin 0.0022 0.1017 0.085
Echinococcus granulosus cyclin G2 0.0022 0.1017 0.085
Echinococcus granulosus cyclin B 0.009 0.4996 0.4903
Echinococcus multilocularis cyclin k 0.0022 0.1017 0.085
Giardia lamblia G2/mitotic-specific cyclin B 0.009 0.4996 1
Schistosoma mansoni cyclin k 0.0022 0.1017 0.1017
Echinococcus granulosus cyclins 0.009 0.4996 0.4903
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0677 0.1097
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0677 0.0677
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0677 0.1097
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.005 0.2654 0.4577
Echinococcus granulosus cyclin y 0.0022 0.1017 0.085
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.2518 0.2518
Echinococcus multilocularis cyclins 0.009 0.4996 0.4903
Echinococcus multilocularis chromatin regulatory protein sir2 0.0016 0.0677 0.0503
Mycobacterium tuberculosis Transcriptional regulatory protein 0.005 0.2654 0.5
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.009 0.4996 0.4903
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.005 0.2654 0.4577
Trichomonas vaginalis cyclin D, putative 0.009 0.4996 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.2518 0.2518
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0022 0.1017 0.085
Loa Loa (eye worm) CYL-1 protein 0.0022 0.1017 0.1547
Trichomonas vaginalis cyclin D, putative 0.0022 0.1017 0.1798
Loa Loa (eye worm) hypothetical protein 0.009 0.4996 1
Echinococcus granulosus chromatin regulatory protein sir2 0.0016 0.0677 0.0503
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.1488 0.2548
Mycobacterium ulcerans NAD-dependent deacetylase 0.005 0.2654 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.4996 1
Toxoplasma gondii hypothetical protein 0.0068 0.373 1
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.005 0.2654 0.4577
Echinococcus granulosus cyclin A3 4 0.0022 0.1017 0.085
Entamoeba histolytica cyclin, putative 0.009 0.4996 1
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0677 0.0838
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.005 0.2654 0.5172
Echinococcus granulosus cyclin 0.0022 0.1017 0.085
Giardia lamblia Transcriptional regulator, Sir2 family 0.005 0.2654 0.4577
Echinococcus granulosus cyclins 0.009 0.4996 0.4903
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0022 0.1017 0.1114
Echinococcus multilocularis Cyclin L1 0.0022 0.1017 0.085
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0016 0.0677 0.0503
Brugia malayi hypothetical protein 0.0022 0.1017 0.1559
Trichomonas vaginalis conserved hypothetical protein 0.009 0.4996 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.1017 0.1559
Giardia lamblia Cyclin A 0.009 0.4996 1
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0022 0.1017 0.085
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0022 0.1017 0.1017
Schistosoma mansoni cyclin G2 0.0022 0.1017 0.1017
Plasmodium falciparum cyclin 1 0.0022 0.1017 0.0787
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.2518 0.2379
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0677 0.0677
Trichomonas vaginalis cyclin B, putative 0.009 0.4996 1
Trichomonas vaginalis cyclin A, putative 0.009 0.4996 1
Schistosoma mansoni cpg binding protein 0.0032 0.1587 0.1587
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0016 0.0677 0.0503
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0022 0.1017 0.0787
Schistosoma mansoni hypothetical protein 0.0176 1 1
Schistosoma mansoni cyclin d 0.0022 0.1017 0.1017
Brugia malayi NAD-dependent deacetylase SIRT1 0.0016 0.0677 0.0838
Leishmania major cyclin 0.009 0.4996 1
Schistosoma mansoni cpg binding protein 0.003 0.1488 0.1488
Schistosoma mansoni hypothetical protein 0.0022 0.1017 0.1017
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0677 0.0825
Trichomonas vaginalis cyclin B3, putative 0.009 0.4996 1
Plasmodium vivax cyclin homologue, putative 0.0022 0.1017 0.172
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0016 0.0677 0.0503
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0182 0.0182
Echinococcus granulosus cyclin b3 0.009 0.4996 0.4903
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0016 0.0677 0.0503
Schistosoma mansoni Cyclin fold protein 0.0022 0.1017 0.1017
Schistosoma mansoni hypothetical protein 0.0022 0.1017 0.1017
Entamoeba histolytica hypothetical protein 0.0022 0.1017 0.0787
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0677 0.1097
Echinococcus multilocularis cyclin G2 0.0022 0.1017 0.085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.2518 0.2379
Toxoplasma gondii cyclin dependent kinase binding protein 0.0022 0.1017 0.1114
Giardia lamblia Cyclin fold protein 1, putative 0.0022 0.1017 0.0787
Entamoeba histolytica cyclin C, putative 0.0022 0.1017 0.0787
Schistosoma mansoni cyclin B 0.009 0.4996 0.4996
Giardia lamblia Hypothetical protein 0.0022 0.1017 0.0787
Schistosoma mansoni cyclin B3 0.009 0.4996 0.4996
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0677 0.1097
Entamoeba histolytica cyclin, putative 0.009 0.4996 1
Toxoplasma gondii histone deacetylase SIR2 0.005 0.2654 0.6475
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.3435 0.3435
Echinococcus granulosus G1:S specific cyclin D1 0.0022 0.1017 0.085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.2518 0.2379
Onchocerca volvulus 0.003 0.1488 0.1185
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.1017 0.1559
Giardia lamblia Hypothetical protein 0.009 0.4996 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.1017 0.1547
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0288 0.0108
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0022 0.1017 0.0787
Echinococcus granulosus cyclins 0.0022 0.1017 0.085
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.1017 0.1559
Echinococcus multilocularis cyclin G2 0.0022 0.1017 0.085
Entamoeba histolytica cyclin family protein 0.009 0.4996 1
Echinococcus multilocularis geminin 0.0176 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.1017 0.0787
Trichomonas vaginalis cyclins, putative 0.009 0.4996 1
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0022 0.1017 0.172
Trichomonas vaginalis cyclin B, putative 0.009 0.4996 1
Echinococcus granulosus cyclins 0.009 0.4996 0.4903
Echinococcus granulosus cyclin G2 0.0022 0.1017 0.085
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.2518 0.4743
Trichomonas vaginalis cyclin B3, putative 0.0022 0.1017 0.1798
Echinococcus multilocularis cyclin B 0.009 0.4996 0.4903
Trichomonas vaginalis cyclins, putative 0.009 0.4996 1
Brugia malayi CXXC zinc finger family protein 0.003 0.1488 0.2559
Schistosoma mansoni cyclin l 0.0022 0.1017 0.1017
Echinococcus multilocularis cyclin y 0.0022 0.1017 0.085
Echinococcus multilocularis cyclins 0.009 0.4996 0.4903
Echinococcus multilocularis cyclins 0.009 0.4996 0.4903
Trypanosoma brucei cyclin 3 0.0022 0.1017 0.0787
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0677 0.0677
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.1017 0.1559
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.2518 0.2518
Loa Loa (eye worm) cyclin domain-containing protein 0.009 0.4996 1
Echinococcus granulosus Cyclin L1 0.0022 0.1017 0.085
Echinococcus multilocularis cyclins 0.009 0.4996 0.4903
Schistosoma mansoni hypothetical protein 0.0176 1 1
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0022 0.1017 0.1114
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.1017 0.1798
Leishmania major mitotic cyclin, putative 0.0022 0.1017 0.0787
Plasmodium vivax cyclin 4, putative 0.0022 0.1017 0.172
Trichomonas vaginalis cyclins, putative 0.0022 0.1017 0.1798
Trichomonas vaginalis cyclin B, putative 0.0022 0.1017 0.1798
Entamoeba histolytica cyclin family protein 0.009 0.4996 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0677 0.0825
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.1017 0.1547
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0677 0.0677
Plasmodium vivax hypothetical protein, conserved 0.0022 0.1017 0.172
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.1017 0.1547
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0677 0.0838
Trichomonas vaginalis cyclin B, putative 0.009 0.4996 1
Echinococcus multilocularis cyclin A3 4 0.0022 0.1017 0.085
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0288 0.0108
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0016 0.0677 0.0503
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0677 0.0825
Toxoplasma gondii cyclin 4, putative 0.0022 0.1017 0.1114
Trypanosoma cruzi CYC2-like cyclin, putative 0.009 0.4996 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0677 0.0677
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0022 0.1017 0.085
Entamoeba histolytica cyclin, domain containing protein 0.0022 0.1017 0.0787
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.1017 0.1547
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.1017 0.1798
Loa Loa (eye worm) hypothetical protein 0.0022 0.1017 0.1547
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.4996 1
Trichomonas vaginalis cyclin B, putative 0.0022 0.1017 0.1798
Trichomonas vaginalis cyclin B, putative 0.009 0.4996 1
Schistosoma mansoni cyclins 0.009 0.4996 0.4996
Giardia lamblia Hypothetical protein 0.0022 0.1017 0.0787
Echinococcus multilocularis cyclins 0.009 0.4996 0.4903
Trichomonas vaginalis cyclin B, putative 0.009 0.4996 1
Toxoplasma gondii hypothetical protein 0.0022 0.1017 0.1114
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0677 0.0677
Onchocerca volvulus 0.009 0.4996 1
Entamoeba histolytica cyclin, domain containing protein 0.0022 0.1017 0.0787
Plasmodium falciparum transcriptional regulatory protein sir2a 0.005 0.2654 0.4577
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.005 0.2654 0.4577
Trichomonas vaginalis cyclins, putative 0.009 0.4996 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.2518 0.4735
Echinococcus multilocularis cpg binding protein 0.0032 0.1587 0.1431
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0677 0.1097
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0677 0.1097
Trypanosoma cruzi cyclin 6, putative 0.009 0.4996 1
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.009 0.4996 1
Echinococcus granulosus cyclin y 0.0022 0.1017 0.085
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0677 0.1097
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0022 0.1017 0.085
Echinococcus granulosus cyclin t1 0.0022 0.1017 0.085
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0016 0.0677 0.0503
Echinococcus multilocularis cyclin b3 0.009 0.4996 0.4903
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.1017 0.1798
Trypanosoma brucei mitotic cyclin 6 0.009 0.4996 1
Schistosoma mansoni g1/s-specific cyclin C 0.0022 0.1017 0.1017
Trypanosoma cruzi cyclin, putative 0.009 0.4996 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.3042 0.7746
Echinococcus granulosus cyclin B3 1 0.009 0.4996 0.4903
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0016 0.0677 0.0503
Echinococcus multilocularis cyclin B3 1 0.009 0.4996 0.4903
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.1017 0.1798
Brugia malayi cyclin fold protein 1 variant b 0.0022 0.1017 0.1559
Trypanosoma cruzi mitotic cyclin, putative 0.0022 0.1017 0.0787
Trypanosoma cruzi cyclin, putative 0.009 0.4996 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.1017 0.1559
Echinococcus multilocularis G1:S specific cyclin D1 0.0022 0.1017 0.085
Loa Loa (eye worm) hypothetical protein 0.009 0.4996 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.4996 1
Schistosoma mansoni cpg binding protein 0.0032 0.1587 0.1587
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0016 0.0677 0.0503
Plasmodium falciparum cyclin 0.009 0.4996 1
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0022 0.1017 0.1547
Echinococcus granulosus cyclins 0.009 0.4996 0.4903
Echinococcus multilocularis cyclins 0.009 0.4996 0.4903
Giardia lamblia Cyclin B-like protein 0.0022 0.1017 0.0787
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0677 0.0825
Trichomonas vaginalis cyclin A, putative 0.0022 0.1017 0.1798
Brugia malayi hypothetical protein 0.0022 0.1017 0.1559
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.005 0.2654 0.5172
Leishmania major mitotic cyclin, putative 0.0022 0.1017 0.0787
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0677 0.1097
Echinococcus multilocularis cyclin y 0.0022 0.1017 0.085
Trichomonas vaginalis cyclins, putative 0.0022 0.1017 0.1798
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.1017 0.1559
Leishmania major cyclin 9, putative 0.0022 0.1017 0.0787
Trypanosoma brucei mitotic cyclin 0.0022 0.1017 0.0787
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.2518 0.2379
Mycobacterium leprae Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) 0.0034 0.1728 0.5
Loa Loa (eye worm) cyclin C 0.0022 0.1017 0.1547
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.1017 0.1547
Plasmodium vivax NAD-dependent deacetylase, putative 0.005 0.2654 1
Echinococcus multilocularis cyclins 0.009 0.4996 0.4903
Trichomonas vaginalis cyclin B3, putative 0.0022 0.1017 0.1798
Echinococcus multilocularis cyclin t1 0.0022 0.1017 0.085
Echinococcus granulosus cyclin k 0.0022 0.1017 0.085

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 0.145 % Binding affinity towards adenosine A3 receptor by measuring its ability to displace [125I]-AB-MECA binding to membranes prepared from HEK-293 cells ChEMBL. 9703464
Inhibition (binding) = 0.145 % Binding affinity towards adenosine A3 receptor by measuring its ability to displace [125I]-AB-MECA binding to membranes prepared from HEK-293 cells ChEMBL. 9703464
Inhibition (binding) = 22 % Binding affinity towards adenosine A2A receptor by measuring its ability to displace [3H]-CGS- 21680 in rat striatal membranes at a concentration of 10e-4 M ChEMBL. 9703464
Inhibition (binding) = 22 % Binding affinity towards adenosine A2A receptor by measuring its ability to displace [3H]-CGS- 21680 in rat striatal membranes at a concentration of 10e-4 M ChEMBL. 9703464
Inhibition (binding) = 30 % Binding affinity towards adenosine A1 receptor by measuring its ability to displace [3H]-R-PIA in rat brain membranes at a concentration of 10e-4 M ChEMBL. 9703464
Inhibition (binding) = 30 % Binding affinity towards adenosine A1 receptor by measuring its ability to displace [3H]-R-PIA in rat brain membranes at a concentration of 10e-4 M ChEMBL. 9703464
Log Ki (binding) = 6.84 uM Displacement of specific [125 I]AB-MECA binding at human Adenosine A3 receptor expressed in HEK cells ChEMBL. 10052977
Log Ki (binding) = 6.84 uM Displacement of specific [125 I]AB-MECA binding at human Adenosine A3 receptor expressed in HEK cells ChEMBL. 10052977
Ratio (binding) > 500 Selectivity for binding affinity towards A1 adenosine receptor in rat brain membrane and human A3 receptor expressed in HEK cells ChEMBL. 9703464

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.