TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 360.408 | Formula: C18H24N4O4
H donors: 3 H acceptors: 4 LogP: 2.09 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCc1nc(N)nc(c1OCCCOc1ccccc1CCC(=O)O)N
InChi: 1S/C18H24N4O4/c1-2-13-16(17(19)22-18(20)21-13)26-11-5-10-25-14-7-4-3-6-12(14)8-9-15(23)24/h3-4,6-7H,2,5,8-11H2,1H3,(H,23,24)(H4,19,20,21,22)
InChiKey: VDGXZSSDCDPCRF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0087	0.0869	0.1698
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0206	0.2505	0.5064
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0083	0.0821	0.1659
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0255	0.0255
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.038	0.4904	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0869	0.1698
Leishmania major	cathepsin L-like protease	0.038	0.4904	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0087	0.0869	0.1698
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0236	0.0396
Plasmodium vivax	vivapain-1	0.0206	0.2505	0.5099
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.038	0.4904	0.4904
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.038	0.4904	1
Echinococcus multilocularis		0.0083	0.0821	0.058
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0087	0.0869	0.1758
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0083	0.0821	0.1659
Brugia malayi	TAR-binding protein	0.0128	0.1431	0.1431
Brugia malayi	Cathepsin L-like precursor	0.038	0.4904	0.4904
Plasmodium falciparum	serine repeat antigen 1	0.0087	0.0869	0.1758
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0119	0.1309	0.1309
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.038	0.4904	1
Entamoeba histolytica	cysteine protease, putative	0.0206	0.2505	0.5108
Echinococcus granulosus	cathepsin b	0.0751	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0087	0.0869	0.065
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0047	0.0325	0.0071
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0338	0.0084
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0083	0.0821	1
Loa Loa (eye worm)	RNA binding protein	0.0128	0.1431	0.1431
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0206	0.2505	0.5064
Entamoeba histolytica	cysteine proteinase, putative	0.0261	0.3268	0.6664
Entamoeba histolytica	cysteine protease, putative	0.0206	0.2505	0.5108
Echinococcus granulosus	geminin	0.0165	0.1943	0.1732
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0206	0.2505	0.2325
Brugia malayi	amine oxidase, flavin-containing family protein	0.0101	0.1058	0.1058
Toxoplasma gondii	cathepsin B	0.0292	0.3693	0.7527
Loa Loa (eye worm)	hypothetical protein	0.0263	0.3295	0.3295
Trypanosoma cruzi	cysteine peptidase, putative	0.038	0.4904	0.49
Echinococcus multilocularis	GPCR, family 2	0.0047	0.0325	0.0071
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0087	0.0869	0.065
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0325	0.0325
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0292	0.3693	0.3542
Echinococcus granulosus	cathepsin L	0.0206	0.2505	0.2308
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0246	0.3057	0.2891
Plasmodium vivax	serine-repeat antigen (SERA)	0.0087	0.0869	0.1758
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0869	0.0869
Brugia malayi	cathepsin F-like cysteine proteinase	0.0087	0.0869	0.0869
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0087	0.0869	0.1698
Plasmodium falciparum	serine repeat antigen 7	0.0087	0.0869	0.1758
Giardia lamblia	Cathepsin B precursor	0.0292	0.3693	1
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0255	0.0436
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0236	0.0396
Leishmania major	cathepsin L-like protease	0.038	0.4904	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0196	0.0401
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0869	0.1698
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0087	0.0869	0.1772
Loa Loa (eye worm)	hypothetical protein	0.0261	0.3268	0.3268
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.038	0.4904	0.477
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0087	0.0869	0.1758
Entamoeba histolytica	cysteine protease, putative	0.0206	0.2505	0.5108
Schistosoma mansoni	hypothetical protein	0.0047	0.0325	0.0093
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.038	0.4904	1
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0246	0.3057	0.2875
Echinococcus multilocularis	Niemann Pick C1 protein	0.0099	0.103	0.0795
Echinococcus granulosus	cathepsin l cysteine peptidase	0.038	0.4904	0.477
Brugia malayi	Papain family cysteine protease containing protein	0.0206	0.2505	0.2505
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.038	0.4904	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0751	1	1
Onchocerca volvulus	Cathepsin F homolog	0.038	0.4904	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0869	0.1698
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1309	0.1309
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0869	0.0869
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0261	0.3268	0.3262
Onchocerca volvulus	Cathepsin L homolog	0.038	0.4904	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.038	0.4904	0.477
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0119	0.1309	0.1309
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0637	0.8433	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0869	0.0869
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0206	0.2505	0.2325
Brugia malayi	MH2 domain containing protein	0.0116	0.1272	0.1272
Leishmania major	cysteine peptidase A (CPA)	0.038	0.4904	1
Entamoeba histolytica	cysteine proteinase 2	0.0206	0.2505	0.5108
Trypanosoma cruzi	major cysteine proteinase, putative	0.0087	0.0869	0.0861
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.038	0.4904	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0141	0.1612	0.1392
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0136	0.154	0.1337
Trypanosoma cruzi	cysteine peptidase, putative	0.038	0.4904	0.49
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.1431	0.1226
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.038	0.4904	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0206	0.2505	0.5108
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0751	1	1
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0606	0.036
Schistosoma mansoni	chromobox protein	0.0068	0.0606	0.0381
Plasmodium falciparum	serine repeat antigen 5	0.0087	0.0869	0.1758
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0087	0.0869	0.0869
Trypanosoma cruzi	cysteine peptidase, putative	0.038	0.4904	0.49
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.038	0.4904	1
Echinococcus granulosus	cathepsin l1	0.0261	0.3268	0.3092
Toxoplasma gondii	cathepsin CPC2	0.0087	0.0869	0.1758
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.1272	0.1272
Entamoeba histolytica	cysteine protease, putative	0.0206	0.2505	0.5108
Entamoeba histolytica	cysteine protease, putative	0.0206	0.2505	0.5108
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.038	0.4904	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.038	0.4904	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.038	0.4904	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0087	0.0869	0.1758
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0087	0.0869	0.1698
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0087	0.0869	0.065
Entamoeba histolytica	cysteine protease, putative	0.0087	0.0869	0.1772
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0206	0.2505	0.5099
Onchocerca volvulus		0.038	0.4904	1
Onchocerca volvulus		0.003	0.0083	0.017
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0196	0.0314
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.038	0.4904	1
Mycobacterium tuberculosis	Possible oxidoreductase	0.0083	0.0821	0.1126
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.038	0.4904	1
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0087	0.0869	0.1758
Brugia malayi	Niemann-Pick C1 protein precursor	0.0099	0.103	0.103
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0083	0.0821	0.1659
Brugia malayi	Cathepsin L-like precursor	0.038	0.4904	0.4904
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0637	0.8433	1
Toxoplasma gondii	histone lysine-specific demethylase	0.0083	0.0821	0.1659
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0136	0.154	0.154
Echinococcus granulosus	cathepsin b	0.0751	1	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0119	0.1309	0.1309
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0087	0.0869	0.1698
Plasmodium falciparum	serine repeat antigen 4	0.0087	0.0869	0.1758
Plasmodium vivax	serine-repeat antigen (SERA)	0.0087	0.0869	0.1758
Brugia malayi	hypothetical protein	0.0083	0.0821	0.0821
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.038	0.4904	1
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0083	0.0821	0.0973
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0087	0.0869	0.0869
Brugia malayi	RNA recognition motif domain containing protein	0.0128	0.1431	0.1431
Loa Loa (eye worm)	hypothetical protein	0.003	0.0083	0.0083
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0751	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.038	0.4904	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0087	0.0869	0.065
Echinococcus granulosus	Niemann Pick C1 protein	0.0099	0.103	0.0795
Echinococcus granulosus	cathepsin l1	0.038	0.4904	0.477
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.038	0.4904	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0087	0.0869	0.065
Entamoeba histolytica	cysteine protease, putative	0.0206	0.2505	0.5108
Entamoeba histolytica	cysteine proteinase, putative	0.038	0.4904	1
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0083	0.0821	0.0813
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0087	0.0869	0.065
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.038	0.4904	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0751	1	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0087	0.0869	0.065
Loa Loa (eye worm)	ctsf protein	0.038	0.4904	0.4904
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.038	0.4904	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0386	0.0386
Trypanosoma cruzi	cysteine peptidase, putative	0.038	0.4904	0.49
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0087	0.0869	0.1698
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0606	0.1158
Echinococcus multilocularis	expressed conserved protein	0.0093	0.0947	0.071
Brugia malayi	Papain family cysteine protease containing protein	0.038	0.4904	0.4904
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0087	0.0869	0.065
Onchocerca volvulus		0.0263	0.3295	0.6719
Schistosoma mansoni	amine oxidase	0.0083	0.0821	0.06
Entamoeba histolytica	cysteine proteinase, putative	0.0206	0.2505	0.5108
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0206	0.2505	0.2498
Brugia malayi	cathepsin L-like cysteine proteinase	0.0087	0.0869	0.0869
Entamoeba histolytica	cysteine protease, putative	0.0206	0.2505	0.5108
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0087	0.0869	0.1758
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.038	0.4904	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0136	0.154	0.1318
Plasmodium falciparum	serine repeat antigen 3	0.0087	0.0869	0.1758
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0087	0.0869	0.1772
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.015	0.1732	0.1732
Echinococcus multilocularis	tar DNA binding protein	0.0128	0.1431	0.1207
Leishmania major	cathepsin L-like protease	0.038	0.4904	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.038	0.4904	1
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0606	0.1158
Echinococcus granulosus	chromobox protein 1	0.0068	0.0606	0.036
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0083	0.0821	0.1659
Brugia malayi	latrophilin 2 splice variant baaae	0.0102	0.1081	0.1081
Plasmodium falciparum	serine repeat antigen 6	0.0087	0.0869	0.1758
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0087	0.0869	0.1758
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.038	0.4904	1
Loa Loa (eye worm)	TAR-binding protein	0.0128	0.1431	0.1431
Trypanosoma cruzi	cruzipain precursor, putative	0.0119	0.1309	0.1302
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1309	0.1309
Schistosoma mansoni	cathepsin B (C01 family)	0.0087	0.0869	0.065
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0087	0.0869	0.1758
Brugia malayi	Latrophilin receptor protein 2	0.0047	0.0325	0.0325
Echinococcus multilocularis	geminin	0.0165	0.1943	0.1732
Brugia malayi	Cathepsin L-like precursor	0.0119	0.1309	0.1309
Trypanosoma cruzi	cysteine proteinase, putative	0.0206	0.2505	0.2498
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.1272	0.1272
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0087	0.0869	0.1698
Schistosoma mansoni	cathepsin F (C01 family)	0.0261	0.3268	0.3106
Brugia malayi	Heterochromatin protein 1	0.0068	0.0606	0.0606
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0869	0.1698
Mycobacterium ulcerans	monoamine oxidase	0.0083	0.0821	0.0973
Leishmania major	hypothetical protein, conserved	0.0024	0.0008	0.0017
Plasmodium vivax	hypothetical protein, conserved	0.0083	0.0821	0.1659
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0087	0.0869	0.0869
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0099	0.103	0.21
Plasmodium falciparum	serine repeat antigen 2	0.0087	0.0869	0.1758
Onchocerca volvulus		0.038	0.4904	1
Plasmodium vivax	vivapain-3	0.0206	0.2505	0.5099
Plasmodium falciparum	serine repeat antigen 9	0.0087	0.0869	0.1758
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.1431	0.1226
Echinococcus multilocularis	cathepsin b	0.0751	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.038	0.4904	1
Brugia malayi	SWIRM domain containing protein	0.0263	0.3295	0.3295
Onchocerca volvulus		0.038	0.4904	1
Leishmania major	cathepsin L-like protease	0.038	0.4904	1
Brugia malayi	Papain family cysteine protease containing protein	0.0087	0.0869	0.0869
Onchocerca volvulus		0.038	0.4904	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0292	0.3693	0.7509
Entamoeba histolytica	cysteine protease, putative	0.0206	0.2505	0.5108
Brugia malayi	fibroinase precursor	0.0087	0.0869	0.0869
Echinococcus granulosus	cathepsin L cysteine proteinase	0.038	0.4904	0.477
Schistosoma mansoni	cathepsin C	0.0087	0.0869	0.065
Giardia lamblia	Cathepsin B precursor	0.0292	0.3693	1
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0083	0.0821	0.1659
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.038	0.4904	0.4904
Trypanosoma cruzi	cysteine proteinase, putative	0.0206	0.2505	0.2498
Entamoeba histolytica	cysteine protease, putative	0.0087	0.0869	0.1772
Loa Loa (eye worm)	cathepsin B	0.0292	0.3693	0.3693
Echinococcus granulosus	GPCR family 2	0.0047	0.0325	0.0071
Entamoeba histolytica	cysteine proteinase, putative	0.0206	0.2505	0.5108
Schistosoma mansoni	patched 1	0.0042	0.0255	0.0021
Entamoeba histolytica	cysteine protease, putative	0.0206	0.2505	0.5108
Brugia malayi	Cathepsin L-like precursor	0.038	0.4904	0.4904
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.038	0.4904	1
Loa Loa (eye worm)	hypothetical protein	0.038	0.4904	0.4904
Trypanosoma cruzi	major cysteine proteinase, putative	0.0087	0.0869	0.0861
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.038	0.4904	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.038	0.4904	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0261	0.3268	0.6634
Brugia malayi	Calcitonin receptor-like protein seb-1	0.015	0.1732	0.1732
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0869	0.0869
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0292	0.3693	0.3688
Onchocerca volvulus	Cathepsin L homolog	0.0087	0.0869	0.1772
Entamoeba histolytica	cysteine proteinase, putative	0.038	0.4904	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0821	0.0821
Leishmania major	cathepsin L-like protease	0.038	0.4904	1
Onchocerca volvulus		0.0087	0.0869	0.1772
Brugia malayi	Cathepsin L-like precursor	0.0261	0.3268	0.3268
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0087	0.0869	0.0869
Loa Loa (eye worm)	hypothetical protein	0.0099	0.103	0.103
Entamoeba histolytica	cysteine protease, putative	0.0206	0.2505	0.5108
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.038	0.4904	1
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0246	0.3057	0.2875
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0083	0.0821	0.0813
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0047	0.0325	0.0325
Trypanosoma cruzi	cysteine peptidase, putative	0.0119	0.1309	0.1302
Leishmania major	cathepsin L-like protease	0.038	0.4904	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0206	0.2505	0.5099
Giardia lamblia	Cathepsin B precursor	0.0292	0.3693	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0136	0.154	0.1337
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.038	0.4904	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.038	0.4904	0.477
Brugia malayi	Cathepsin L-like precursor	0.038	0.4904	0.4904
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0083	0.0821	0.1126
Onchocerca volvulus		0.038	0.4904	1
Schistosoma mansoni	hypothetical protein	0.0165	0.1943	0.1749
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0196	0.0314
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0292	0.3693	0.7531
Loa Loa (eye worm)	hypothetical protein	0.0751	1	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0087	0.0869	0.1758
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0087	0.0869	0.1698
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.038	0.4904	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1058	0.1058
Plasmodium vivax	unspecified product	0.0119	0.1309	0.2657
Schistosoma mansoni	hypothetical protein	0.0165	0.1943	0.1749
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0087	0.0869	0.065
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0136	0.154	0.1337
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0087	0.0869	0.1698
Echinococcus multilocularis	cysteine protease	0.038	0.4904	0.477
Trypanosoma cruzi	cysteine protease, putative	0.0206	0.2505	0.2498
Schistosoma mansoni	hypothetical protein	0.0102	0.1081	0.0867
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0869	0.1698
Toxoplasma gondii	cathepsin CPC1	0.0087	0.0869	0.1758
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0869	0.0869
Brugia malayi	Papain family cysteine protease containing protein	0.0206	0.2505	0.2505
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0606	0.036
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0087	0.0869	0.1698
Echinococcus multilocularis	cathepsin b	0.0751	1	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0047	0.0325	0.0071
Leishmania major	UDP-galactopyranose mutase	0.0083	0.0821	0.1673
Loa Loa (eye worm)	hypothetical protein	0.0261	0.3268	0.3268
Schistosoma mansoni	cathepsin s	0.0119	0.1309	0.1101
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0047	0.0325	0.0325
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0083	0.0821	0.06
Loa Loa (eye worm)	cysteine protease	0.038	0.4904	0.4904
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0087	0.0869	0.1758
Plasmodium falciparum	protoporphyrinogen oxidase	0.0083	0.0821	0.1659
Echinococcus multilocularis	cathepsin L	0.0087	0.0869	0.063
Echinococcus granulosus	expressed conserved protein	0.0093	0.0947	0.071
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0261	0.3268	0.3268
Plasmodium vivax	unspecified product	0.0087	0.0869	0.1758
Echinococcus granulosus	cathepsin L	0.0087	0.0869	0.063
Brugia malayi	Papain family cysteine protease containing protein	0.0087	0.0869	0.0869
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.01	0.1051	0.0836
Trypanosoma cruzi	cruzipain precursor, putative	0.038	0.4904	0.49
Entamoeba histolytica	cysteine protease, putative	0.0087	0.0869	0.1772
Leishmania major	cathepsin L-like protease	0.038	0.4904	1
Entamoeba histolytica	cysteine protease, putative	0.0087	0.0869	0.1772
Schistosoma mansoni	amine oxidase	0.0083	0.0821	0.06
Plasmodium vivax	hypothetical protein, conserved	0.0083	0.0821	0.1659
Entamoeba histolytica	cysteine proteinase, putative	0.0206	0.2505	0.5108
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.038	0.4904	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0136	0.154	0.1318
Entamoeba histolytica	cysteine protease, putative	0.0206	0.2505	0.5108
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0087	0.0869	0.0869
Toxoplasma gondii	cathepsin CPL	0.038	0.4904	1
Entamoeba histolytica	cysteine proteinase, putative	0.0206	0.2505	0.5108
Loa Loa (eye worm)	hypothetical protein	0.015	0.1732	0.1732
Onchocerca volvulus		0.0261	0.3268	0.6664
Brugia malayi	hypothetical protein	0.0024	0.0008	0.0008
Brugia malayi	cathepsin L-like precursor	0.0261	0.3268	0.3268
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0261	0.3268	0.6634
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.1431	0.1226
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.038	0.4904	1
Onchocerca volvulus		0.038	0.4904	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0869	0.1698
Echinococcus multilocularis	cathepsin L cysteine protease	0.038	0.4904	0.477
Loa Loa (eye worm)	fibroinase	0.038	0.4904	0.4904
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0087	0.0869	0.1698
Plasmodium falciparum	serine repeat antigen 8	0.0087	0.0869	0.1758
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0087	0.0869	0.1758
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0206	0.2505	0.5099
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0087	0.0869	0.1758
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0087	0.0869	0.1758
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.038	0.4904	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0087	0.0869	0.0869
Schistosoma mansoni	hypothetical protein	0.0047	0.0325	0.0093
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0087	0.0869	0.065
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0255	0.0255
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0083	0.0821	0.5
Echinococcus granulosus	chromobox protein 1	0.0068	0.0606	0.036
Schistosoma mansoni	hypothetical protein	0.0047	0.0325	0.0093
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0206	0.2505	0.2325
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.038	0.4904	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1309	0.1309
Echinococcus multilocularis	cysteine protease	0.038	0.4904	0.477
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0087	0.0869	0.1758
Loa Loa (eye worm)	hypothetical protein	0.0246	0.3057	0.3057
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.038	0.4904	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0136	0.154	0.1318
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.015	0.1732	0.1732
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.0869	0.1698
Entamoeba histolytica	cysteine protease, putative	0.038	0.4904	1
Plasmodium vivax	unspecified product	0.0206	0.2505	0.5099
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0821	0.0821
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0083	0.0821	0.058
Onchocerca volvulus		0.038	0.4904	1
Entamoeba histolytica	hypothetical protein	0.0087	0.0869	0.1772
Echinococcus multilocularis	cathepsin L	0.0206	0.2505	0.2308
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0047	0.0325	0.0071
Echinococcus granulosus	cysteine protease	0.0206	0.2505	0.2308
Plasmodium vivax	vivapain-2	0.038	0.4904	1
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.1431	0.1226
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0047	0.0325	0.0071
Brugia malayi	cathepsin L precursor	0.0087	0.0869	0.0869
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.038	0.4904	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0236	0.0482
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.038	0.4904	1
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0553	0.7286	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.038	0.4904	1
Brugia malayi	Cathepsin L-like precursor	0.0261	0.3268	0.3268
Echinococcus granulosus	cathepsin L cysteine protease	0.0206	0.2505	0.2308
Plasmodium vivax	vivapain-2	0.038	0.4904	1
Mycobacterium ulcerans	oxidoreductase	0.0083	0.0821	0.0973
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.038	0.4904	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0128	0.1431	0.1431
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0136	0.154	0.1318
Entamoeba histolytica	cysteine protease, putative	0.0087	0.0869	0.1772
Brugia malayi	CHE-14 protein	0.0042	0.0255	0.0255
Trypanosoma cruzi	cysteine peptidase, putative	0.0206	0.2505	0.2498
Leishmania major	cathepsin L-like protease	0.038	0.4904	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0141	0.1612	0.1392
Schistosoma mansoni	hypothetical protein	0.0047	0.0325	0.0093
Echinococcus granulosus	tar DNA binding protein	0.0128	0.1431	0.1207
Brugia malayi	Cathepsin L-like precursor	0.038	0.4904	0.4904
Loa Loa (eye worm)	hypothetical protein	0.0246	0.3057	0.3057
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.1431	0.1226
Brugia malayi	RNA binding protein	0.0128	0.1431	0.1431
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.038	0.4904	1
Schistosoma mansoni	cathepsin F (C01 family)	0.038	0.4904	0.4781
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0292	0.3693	0.7527
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.0606	0.0606
Brugia malayi	chromobox protein homolog 3	0.0038	0.0196	0.0196
Brugia malayi	Papain family cysteine protease containing protein	0.0087	0.0869	0.0869
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.0869	0.1698
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0008	0.0008
Entamoeba histolytica	cysteine protease, putative	0.0206	0.2505	0.5108
Entamoeba histolytica	cysteine protease, putative	0.0087	0.0869	0.1772
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0087	0.0869	0.1758
Loa Loa (eye worm)	hypothetical protein	0.0261	0.3268	0.3268
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1081	0.1081
Schistosoma mansoni	cathepsin F (C01 family)	0.038	0.4904	0.4781
Mycobacterium ulcerans	dehydrogenase	0.0083	0.0821	0.0973
Onchocerca volvulus	Cathepsin L homolog	0.038	0.4904	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0196	0.0196
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.038	0.4904	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0136	0.154	0.154
Schistosoma mansoni	chromobox protein	0.0068	0.0606	0.0381
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0751	1	1
Brugia malayi	Cathepsin L-like precursor	0.038	0.4904	0.4904
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0869	0.0869
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0083	0.0821	0.058
Entamoeba histolytica	cysteine protease, putative	0.0206	0.2505	0.5108

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 56 nM	Antimalarial activity against Plasmodium falciparum V1/S harboring DHFR N51I+C59R+S108N+I164L quadruple mutant assessed as reduction parasite growth by [3H]-hypoxanthine incorporation assay	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3040038

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1799225