Detailed information for compound 1799941

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 516.517 | Formula: C29H25FN2O6
  • H donors: 0 H acceptors: 3 LogP: 5.25 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CO/C=C(\c1ccccc1COc1cc(nn1C)c1ccccc1OC(=O)c1ccc(cc1)F)/C(=O)OC
  • InChi: 1S/C29H25FN2O6/c1-32-27(37-17-20-8-4-5-9-22(20)24(18-35-2)29(34)36-3)16-25(31-32)23-10-6-7-11-26(23)38-28(33)19-12-14-21(30)15-13-19/h4-16,18H,17H2,1-3H3/b24-18+
  • InChiKey: BQBCQLNHNZUJJG-HKOYGPOVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Cytochrome b Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii apocytochrome b, putative Get druggable targets OG5_128504 All targets in OG5_128504
Onchocerca volvulus Get druggable targets OG5_128504 All targets in OG5_128504
Babesia bovis cytochrome b Get druggable targets OG5_128504 All targets in OG5_128504
Mycobacterium tuberculosis Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) Get druggable targets OG5_128504 All targets in OG5_128504
Plasmodium yoelii Cytochrome b, putative Get druggable targets OG5_128504 All targets in OG5_128504
Wolbachia endosymbiont of Brugia malayi cytochrome b subunit of the bc complex Get druggable targets OG5_128504 All targets in OG5_128504
Echinococcus granulosus cytochrome B Get druggable targets OG5_128504 All targets in OG5_128504
Toxoplasma gondii cytochrome b Get druggable targets OG5_128504 All targets in OG5_128504
Plasmodium knowlesi cytochrome b Get druggable targets OG5_128504 All targets in OG5_128504
Plasmodium yoelii Cytochrome b, putative Get druggable targets OG5_128504 All targets in OG5_128504
Mycobacterium ulcerans ubiquinol-cytochrome C reductase QcrB Get druggable targets OG5_128504 All targets in OG5_128504
Theileria parva cytochrome b Get druggable targets OG5_128504 All targets in OG5_128504
Plasmodium vivax cytochrome b Get druggable targets OG5_128504 All targets in OG5_128504
Plasmodium yoelii Cytochrome b, putative Get druggable targets OG5_128504 All targets in OG5_128504
Schistosoma mansoni cytochrome b Get druggable targets OG5_128504 All targets in OG5_128504
Plasmodium berghei cytochrome b Get druggable targets OG5_128504 All targets in OG5_128504
Toxoplasma gondii apocytochrome b, putative Get druggable targets OG5_128504 All targets in OG5_128504
Plasmodium falciparum cytochrome b Get druggable targets OG5_128504 All targets in OG5_128504
Mycobacterium leprae Probable Ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) Get druggable targets OG5_128504 All targets in OG5_128504
Schistosoma japonicum ko:K00412 ubiquinol-cytochrome c reductase cytochrome b subunit, putative Get druggable targets OG5_128504 All targets in OG5_128504
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0488 0.1238
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.084 0.2034
Loa Loa (eye worm) hypothetical protein 0.0058 0.0666 0.1611
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0194 0.0405
Trichomonas vaginalis glutaminase, putative 0.0293 0.3884 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0813 0.0805
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0497 0.0495
Onchocerca volvulus 0.0021 0.0162 0.0396
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0762 0.1787
Loa Loa (eye worm) DR-78 0.001 0.0008 0.0016
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0894 0.2224
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0414 0.0976
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0115 0.1177
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0474 0.516
Schistosoma mansoni inhibitor of apoptosis protein 0.0058 0.0666 0.0658
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0095 0.0094
Schistosoma mansoni cytochrome b 0.005 0.0561 0.0553
Brugia malayi Importin beta-1 subunit 0.0029 0.027 0.0694
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0759 0.0751
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.1624 0.3934
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0762 0.0761
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0474 0.516
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0025 0.0023
Plasmodium vivax importin-beta 2, putative 0.0029 0.027 0.0981
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.009
Echinococcus granulosus chromobox protein 1 0.0075 0.0894 0.0892
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0413 0.0975
Schistosoma mansoni DNA polymerase eta 0.0016 0.0084 0.0076
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0414 0.4684
Schistosoma mansoni glutaminase 0.0293 0.3884 0.3879
Echinococcus granulosus Polycystic kidney disease protein 0.0189 0.2455 0.2454
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0162 0.0416
Brugia malayi conserved hypotetical protein 0.001 0.0008 0.0021
Brugia malayi ecdysone receptor 0.001 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0388
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0355 0.0915
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0162 0.0153
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.1019 0.4074
Brugia malayi RNA binding protein 0.0069 0.0813 0.2092
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.084 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0162 0.016
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.077 0.1028
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.0894 0.2164
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0162 0.0416
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.1624 0.3934
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0413 0.0975
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0162 0.0153
Brugia malayi ecdysteroid receptor 0.0021 0.0162 0.0416
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0162 0.0396
Brugia malayi jmjC domain containing protein 0.0017 0.0101 0.0261
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0101 0.0093
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0388
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0084 0.0076
Loa Loa (eye worm) hypothetical protein 0.0189 0.2455 0.5951
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0377 0.437
Brugia malayi Muscleblind-like protein 0.0162 0.2091 0.5384
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0624 0.0622
Echinococcus multilocularis snurportin 1 0.0311 0.4124 0.4123
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0162 0.016
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0384 0.4459
Plasmodium falciparum LCCL domain-containing protein 0.0189 0.2455 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0497 0.4709
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0597 0.0589
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0039 0.0027
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0008 0.0021
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0162 0.016
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0162 0.016
Brugia malayi MH2 domain containing protein 0.0128 0.1624 0.4181
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0388
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0101 0.0093
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0267 0.0969
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0619 0.0618
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0762 0.0761
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0388
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0162 0.0416
Schistosoma mansoni hypothetical protein 0.0016 0.0095 0.0087
Loa Loa (eye worm) hypothetical protein 0.004 0.0414 0.1
Brugia malayi RNA, U transporter 1 0.0083 0.1004 0.2586
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0253 0.2244
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.077 0.1028
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0156 0.1999 0.1997
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0619 0.0611
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.0624 0.1421
Echinococcus granulosus chromobox protein 1 0.0075 0.0894 0.0892
Brugia malayi tailless protein 0.001 0.0008 0.0021
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0084 0.0216
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0095 0.0245
Leishmania major DNA polymerase kappa, putative 0.0023 0.0181 0.128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1205 0.1198
Leishmania major GTP-binding protein, putative 0.0021 0.0164 0.1068
Schistosoma mansoni chromobox protein 0.0012 0.0039 0.003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0056
Onchocerca volvulus 0.0058 0.0666 0.1697
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0253 0.2244
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0813 0.0805
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0762 0.0755
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0101 0.01
Entamoeba histolytica Ran family GTPase 0.0021 0.0164 0.157
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0619 0.0618
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0101 0.01
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0194 0.0405
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0162 0.016
Echinococcus granulosus geminin 0.0182 0.2358 0.2357
Loa Loa (eye worm) cytochrome b 0.005 0.0561 0.1357
Echinococcus granulosus Chromobox protein 3 0.0012 0.0039 0.0037
Loa Loa (eye worm) hypothetical protein 0.0189 0.2455 0.5951
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.0734 0.0733
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0162 0.0153
Brugia malayi Inositol-1 0.004 0.0413 0.1064
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0414 0.5489
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0414 0.4367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0162 0.0388
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0813 0.0811
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0164 0.0163
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0101 0.0093
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0194 0.1462
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.065
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0722 0.699
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0162 0.0416
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0039 0.0027
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0414 0.0406
Schistosoma mansoni hypothetical protein 0.0035 0.0355 0.0347
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0134 0.0248
Echinococcus granulosus transcription factor btf3 0.0038 0.0384 0.0383
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0156 0.1999 0.1992
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0384 0.1454
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0579 0.1491
Echinococcus granulosus lipoxygenase domain containing protein 0.0189 0.2455 0.2454
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0253 0.0914
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0474 0.5548
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0624 0.0622
Schistosoma mansoni inositol monophosphatase 0.004 0.0413 0.0406
Toxoplasma gondii hypothetical protein 0.0029 0.0267 0.2377
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0162 0.016
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.084 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.1019 1
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0162 0.0153
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0039 0.0037
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0474 0.5548
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0101 0.01
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0101 0.01
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0125 0.0124
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0384 0.0928
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0162 0.016
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0025 0.0016
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0008 0.0007
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0039 0.0067
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0162 0.0416
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0414 0.0412
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0162 0.0416
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0134 0.0248
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.1019 0.1012
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0813 0.1967
Loa Loa (eye worm) hypothetical protein 0.0016 0.0095 0.0227
Trypanosoma brucei unspecified product 0.0037 0.0377 0.437
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0162 0.0416
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0162 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0162 0.0416
Echinococcus multilocularis RUN 0.0189 0.2455 0.2454
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0162 0.0153
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0384 0.1454
Schistosoma mansoni importin beta-1 0.0029 0.027 0.0262
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0729 0.9846 0.9846
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.077 0.0768
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0181 0.1979
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0657 0.1589
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0039 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0474 0.5548
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.009 0.0133
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.1019 0.1745
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0619 0.7078
Schistosoma mansoni hypothetical protein 0.0058 0.0666 0.0658
Echinococcus granulosus flap endonuclease 1 0.0028 0.0253 0.0252
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.1019 1
Plasmodium falciparum importin beta, putative 0.0029 0.027 0.0981
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0164 0.0547
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0488 0.1169
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0384 0.0899
Brugia malayi hypothetical protein 0.0011 0.0025 0.0063
Schistosoma mansoni inositol monophosphatase 0.004 0.0413 0.0406
Brugia malayi glutaminase DH11.1 0.0293 0.3884 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0384 0.0899
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0101 0.0235
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0488 0.1169
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0162 0.0416
Onchocerca volvulus 0.0012 0.0039 0.0079
Schistosoma mansoni hypothetical protein 0.0106 0.1325 0.1318
Brugia malayi Flap endonuclease-1 0.0028 0.0253 0.0653
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0497 0.1192
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0413 0.4358
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0413 0.4811
Echinococcus multilocularis dna polymerase eta 0.0016 0.0084 0.0082
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0444 0.1126
Loa Loa (eye worm) hypothetical protein 0.0162 0.2091 0.5068
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0162 0.016
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.0624 0.1421
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0619 0.151
Trichomonas vaginalis ran, putative 0.0021 0.0164 0.0327
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0162 0.0416
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0384 0.357
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0039 0.003
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.084 0.2163
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.0007
Echinococcus granulosus lipoxygenase domain containing protein 0.0189 0.2455 0.2454
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0388
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0134 0.0248
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0039 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0327 0.3766
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0619 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0008 0.0021
Schistosoma mansoni hypothetical protein 0.0189 0.2455 0.2449
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0162 0.016
Schistosoma mansoni coup transcription factor 0.0021 0.0162 0.0153
Plasmodium falciparum cytochrome b 0.0083 0.1001 0.3998
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0474 0.5548
Loa Loa (eye worm) hypothetical protein 0.0017 0.0101 0.0242
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0162 0.0388
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0388
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0253 0.1958
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0164 0.0424
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0039 0.0099
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0619 0.7078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1205 0.1198
Loa Loa (eye worm) hypothetical protein 0.0033 0.0321 0.0774
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Trypanosoma brucei DNA polymerase eta, putative 0.0016 0.0084 0.0802
Schistosoma mansoni hypothetical protein 0.0182 0.2358 0.2352
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0474 0.5548
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.084 1
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0063 0.0148
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0008 0.0007
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0058 0.0666 0.0658
Brugia malayi Nuclear hormone receptor E75 0.001 0.0008 0.0021
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0253 0.0252
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0101 0.0286
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0474 0.516
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0253 0.2681
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0414 0.0412
Echinococcus granulosus cytochrome B 0.0083 0.1001 0.0999
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0056
Brugia malayi beta-NAC-like protein 0.0038 0.0384 0.099
Loa Loa (eye worm) hypothetical protein 0.0033 0.0327 0.079
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0474 0.5548
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.1019 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0063 0.0061
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0008 0.0016
Echinococcus multilocularis microtubule associated protein 2 0.0741 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0025 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0444 0.1056
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0095 0.0094
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0162 0.016
Brugia malayi nuclear hormone receptor 0.0021 0.0162 0.0416
Echinococcus multilocularis Chromo domain 0.0012 0.0039 0.0037
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0008 0.0007
Schistosoma mansoni hypothetical protein 0.0016 0.0095 0.0087
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0039 0.0027
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0813 0.2092
Echinococcus granulosus inhibitor of apoptosis protein 0.0058 0.0666 0.0664
Echinococcus granulosus macrophage expressed protein 0.0106 0.1325 0.1324
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0181 0.128
Brugia malayi nuclear receptor NHR-88 0.0021 0.0162 0.0416
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0162 0.016
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0008 0.0021
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0384 0.3976
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0384 0.3976
Schistosoma mansoni chromobox protein 0.0075 0.0894 0.0886
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0101 0.0242
Brugia malayi cytochrome b 0.005 0.0561 0.1445
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.077 0.0768
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0619 0.5948
Toxoplasma gondii apocytochrome b, putative 0.0032 0.0311 0.2825
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.1019 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0162 0.0153
Loa Loa (eye worm) hypothetical protein 0.0017 0.0101 0.0242
Brugia malayi nuclear receptor RXR 0.001 0.0008 0.0021
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.1205 0.3104
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0384 0.0899
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0162 0.0388
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0474 0.0175
Schistosoma mansoni cpg binding protein 0.0033 0.0317 0.0309
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0474 0.5548
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0384 0.4314
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0813 0.0805
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0414 0.0406
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.077 0.1983
Brugia malayi hypothetical protein 0.0189 0.2455 0.6321
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0414 0.0412
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0008 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.1205 0.1204
Giardia lamblia DINP protein human, muc B family 0.0023 0.0181 0.0353
Brugia malayi nuclear receptor NHR-67 0.001 0.0008 0.0021
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0162 0.0153
Echinococcus granulosus Chromo domain 0.0012 0.0039 0.0037
Brugia malayi polk-prov protein 0.0033 0.0327 0.0843
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0414 0.4818
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0058 0.0666 0.1714
Schistosoma mansoni hypothetical protein 0.0311 0.4124 0.412
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0044 0.0474 0.1132
Plasmodium falciparum flap endonuclease 1 0.0028 0.0253 0.0914
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.1019 0.1018
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0474 0.0175
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.077 0.1806
Echinococcus granulosus dna polymerase eta 0.0016 0.0084 0.0082
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0008 0.0007
Brugia malayi nuclear receptor RXR 0.0011 0.0025 0.0063
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.084 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0619 0.7078
Mycobacterium ulcerans ubiquinol-cytochrome C reductase QcrB 0.0293 0.3883 0.9999
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0039 0.0099
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0414 0.1066
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.009
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0432 0.043
Brugia malayi Doublecortin family protein 0.0189 0.2455 0.6321
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0162 0.016
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0619 0.1498
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0164 0.1342
Plasmodium falciparum heterochromatin protein 1 0.0012 0.0039 0.0027
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.1019 0.208
Brugia malayi Protein cec-1. 0.0012 0.0039 0.0099
Mycobacterium ulcerans glutaminase 0.0293 0.3884 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0066 0.077 0.0762
Brugia malayi TAR-binding protein 0.0069 0.0813 0.2092
Brugia malayi hypothetical protein 0.001 0.0008 0.0021
Echinococcus multilocularis lipoxygenase domain containing protein 0.0189 0.2455 0.2454
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0162 0.0388
Onchocerca volvulus 0.0013 0.0048 0.0102
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.0007
Echinococcus multilocularis inhibitor of apoptosis protein 0.0058 0.0666 0.0664
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0413 0.4358
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.1205 0.1204
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0413 0.3863
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0413 0.4358
Brugia malayi Nuclear hormone receptor E75 0.001 0.0008 0.0021
Echinococcus granulosus snurportin 1 0.0311 0.4124 0.4123
Schistosoma mansoni chromobox protein 0.0075 0.0894 0.0886
Loa Loa (eye worm) helicase 0.0012 0.0039 0.009
Echinococcus granulosus tumor protein p63 0.0363 0.4831 0.483
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0388
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0181 0.0255
Brugia malayi jmjC domain containing protein 0.0017 0.0101 0.0261
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0008 0.0021
Echinococcus granulosus GPCR family 2 0.0016 0.0095 0.0094
Mycobacterium leprae Probable Ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) 0.0293 0.3883 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.0734 0.0733
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0759 0.1836
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0199
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0115 0.1177
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0162 0.016
Echinococcus multilocularis macrophage expressed protein 0.0106 0.1325 0.1324
Echinococcus multilocularis chromobox protein 1 0.0075 0.0894 0.0892
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0164 0.1068
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.1019 0.1745
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0134 0.0248
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0058 0.0666 0.1714
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.084 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Brugia malayi hypothetical protein 0.0189 0.2455 0.6321
Schistosoma mansoni flap endonuclease-1 0.0025 0.0217 0.0209
Loa Loa (eye worm) RNA binding protein 0.0069 0.0813 0.1967
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0293 0.0706
Echinococcus multilocularis dna polymerase kappa 0.0044 0.0474 0.0472
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0162 0.0153
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0414 0.0412
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.1019 0.1018
Brugia malayi Probable ClpP-like protease 0.0084 0.1019 0.2624
Loa Loa (eye worm) acetyltransferase 0.0156 0.1999 0.4844
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0056
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0101 0.0093
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0388
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0474 0.5548
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0162 0.0396
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0162 0.0416
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0762 0.74
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0432 0.043
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0762 0.1006
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0253 0.0559
Schistosoma mansoni cpg binding protein 0.0031 0.0293 0.0285
Loa Loa (eye worm) hypothetical protein 0.0035 0.0355 0.0857
Echinococcus multilocularis transcription factor btf3 0.0038 0.0384 0.0383
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0101 0.0235
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0759 0.0751
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0095 0.0227
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0008 0.0007
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0619 0.151
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0327 0.3766
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0445 0.6164
Schistosoma mansoni ran 0.0021 0.0164 0.0156
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0413 0.0975
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0445 0.5067
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0164 0.0547
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0039 0.0037
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0162 0.0396
Echinococcus granulosus RUN 0.0189 0.2455 0.2454
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0101 0.01
Schistosoma mansoni hypothetical protein 0.0012 0.0039 0.003
Loa Loa (eye worm) hypothetical protein 0.0053 0.0597 0.1444
Trypanosoma brucei protein kinase, putative 0.0055 0.0619 0.7313
Schistosoma mansoni hypothetical protein 0.0439 0.5875 0.5871
Loa Loa (eye worm) hypothetical protein 0.0017 0.0101 0.0242
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.1205 0.292
Schistosoma mansoni chromobox protein 0.0012 0.0039 0.003
Onchocerca volvulus 0.0033 0.0321 0.0806
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0101 0.0703
Entamoeba histolytica hypothetical protein 0.0038 0.0384 0.4314
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.084 0.0839
Schistosoma mansoni hypothetical protein 0.0016 0.0095 0.0087
Echinococcus granulosus tar DNA binding protein 0.0069 0.0813 0.0811
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0765 0.0758
Echinococcus granulosus phd:f box containing protein 0.0017 0.0101 0.01
Brugia malayi steroid hormone receptor 0.0021 0.0162 0.0416
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0729 0.9846 0.9846
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.009
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0414 0.4367
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0813 0.0805
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1205 0.1198
Leishmania major importin beta-1 subunit, putative 0.0024 0.0194 0.1462
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0619 0.7078
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0058 0.0666 0.0664
Brugia malayi Heterochromatin protein 1 0.0075 0.0894 0.2302
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0039 0.0067
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0194 0.0405
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0162 0.0416
Echinococcus multilocularis Polycystic kidney disease protein 0.0189 0.2455 0.2454
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0134 0.0248
Echinococcus multilocularis GPCR, family 2 0.0016 0.0095 0.0094
Echinococcus multilocularis importin subunit beta 1 0.0029 0.027 0.0268
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0474 0.516
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0579 0.1401
Loa Loa (eye worm) hypothetical protein 0.0042 0.0444 0.1074
Entamoeba histolytica hypothetical protein 0.0024 0.0194 0.1942
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0414 0.0412
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0013 0.0048 0.004
Brugia malayi hypothetical protein 0.001 0.0008 0.0021
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0039 0.0099
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0413 0.0412
Leishmania major basic transcription factor 3a, putative 0.0038 0.0384 0.3976
Schistosoma mansoni microtubule-associated protein tau 0.0741 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0162 0.0388
Echinococcus granulosus cpg binding protein 0.0033 0.0317 0.0315
Brugia malayi hypothetical protein 0.0012 0.0039 0.0099
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0008 0.0007
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0162 0.0416
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0474 0.5548
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0164 0.1068
Toxoplasma gondii cytochrome b 0.0083 0.1001 0.9814
Schistosoma mansoni lipoxygenase 0.0389 0.5195 0.5191
Loa Loa (eye worm) hypothetical protein 0.0058 0.0666 0.1611
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0162 0.016
Loa Loa (eye worm) hypothetical protein 0.0052 0.0579 0.1401
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0034 0.002
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0762 0.8973
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0083 0.0115
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0084 0.0216
Loa Loa (eye worm) doublecortin family protein 0.0189 0.2455 0.5951
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0762 0.1006
Onchocerca volvulus 0.0012 0.0039 0.0079
Schistosoma mansoni rab6-interacting 0.0189 0.2455 0.2449
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0101 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0162 0.0416
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0025 0.0056
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0134 0.0248
Echinococcus multilocularis tumor protein p63 0.0363 0.4831 0.483
Echinococcus granulosus chromobox protein 2 0.0012 0.0039 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0474 0.5548
Echinococcus multilocularis lipoxygenase domain containing protein 0.0189 0.2455 0.2454
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0414 0.0976
Loa Loa (eye worm) glutaminase 0.0293 0.3884 0.9416
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0162 0.016
Mycobacterium tuberculosis Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) 0.0293 0.3883 1
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0162 0.0416
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.4124 1
Schistosoma mansoni lipoxygenase 0.0729 0.9846 0.9846
Schistosoma mansoni hypothetical protein 0.0016 0.0095 0.0087
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.027 0.3063
Echinococcus granulosus dnaJ subfamily B 0.0439 0.5875 0.5874
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0357 0.0248
Schistosoma mansoni transcription factor btf3 0.0038 0.0384 0.0377
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0134 0.0248
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0084 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0277 0.062
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0619 0.7078
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0162 0.0153
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.009
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0413 0.4675
Schistosoma mansoni ran 0.0021 0.0164 0.0156
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0162 0.0388
Echinococcus granulosus dna polymerase kappa 0.0044 0.0474 0.0472
Brugia malayi chromobox protein homolog 3 0.0042 0.0444 0.1145
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0357 0.0718
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0253 0.2243
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0063 0.0061
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.1939 0.1938
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0813 0.1967
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0084 0.0076
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0039 0.0067
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.1019 1
Echinococcus granulosus muscleblind protein 0.0162 0.2091 0.209
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0162 0.0153
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0008 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0619 0.151
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0579 0.1491
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0762 0.1006
Plasmodium vivax multidomain scavenger receptor, putative 0.0189 0.2455 1
Onchocerca volvulus 0.0053 0.0597 0.152
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0039 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0056
Plasmodium vivax JmjC domain containing protein 0.0017 0.0101 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0162 0.0416
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.009
Brugia malayi jmjC domain containing protein 0.0017 0.0101 0.0261
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0101 0.0242
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0497 0.1192
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0162 0.016
Onchocerca volvulus 0.0189 0.2455 0.6314
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0445 0.1703
Schistosoma mansoni rab6-interacting 0.0189 0.2455 0.2449
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0101 0.01
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0095 0.0245
Loa Loa (eye worm) hypothetical protein 0.0162 0.2091 0.5068
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0619 0.0618
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.009 0.0133
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0084 0.0082
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0008 0.0007
Schistosoma mansoni polycystin 1-related 0.0189 0.2455 0.2449
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0039 0.003
Echinococcus granulosus importin subunit beta 1 0.0029 0.027 0.0268
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0095 0.0094
Echinococcus multilocularis cpg binding protein 0.0033 0.0317 0.0315
Echinococcus multilocularis dnaJ subfamily B 0.0439 0.5875 0.5874
Onchocerca volvulus Deterin homolog 0.0058 0.0666 0.1697
Wolbachia endosymbiont of Brugia malayi cytochrome b subunit of the bc complex 0.0083 0.1001 0.9696
Loa Loa (eye worm) inositol-1 0.004 0.0413 0.0999
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0162 0.0153
Brugia malayi MAP kinase sur-1 0.0055 0.0619 0.1594
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.077 0.9072
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0025 0.0063
Echinococcus multilocularis muscleblind protein 1 0.0162 0.2091 0.209
Brugia malayi jmjC domain containing protein 0.0065 0.0759 0.1953
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0619 0.7078
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0084 0.0082
Plasmodium vivax heterochromatin protein 1, putative 0.0012 0.0039 0.0027
Onchocerca volvulus 0.0031 0.0293 0.0734
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0115 0.1177
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0414 0.4367
Echinococcus multilocularis muscleblind protein 0.0162 0.2091 0.209
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.1205 0.1204
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0039 0.0037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.1205 0.1204
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0474 0.5548
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.0734 0.0733
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0008 0.0016
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.1019 1
Leishmania major hypothetical protein, conserved 0.0017 0.0101 0.0235
Brugia malayi CXXC zinc finger family protein 0.0031 0.0293 0.0754
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0444 0.1056
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0008 0.0007
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0164 0.1784
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0095 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0162 0.0388
Brugia malayi nuclear hormone receptor 0.001 0.0008 0.0021
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0162 0.0153
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0267 0.0969
Schistosoma mansoni hypothetical protein 0.0182 0.2358 0.2352
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.027 0.3063
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.1019 0.4074
Echinococcus multilocularis chromobox protein 2 0.0012 0.0039 0.0037
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0253 0.0611
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0008 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0813 0.0805
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0619 0.7313
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0414 0.0976
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0134 0.0248
Brugia malayi jmjC domain containing protein 0.0017 0.0101 0.0261
Schistosoma mansoni cytochrome b 0.0083 0.1001 0.0993
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0058 0.0666 0.0664
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0413 0.0412
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.027 0.2407
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0125 0.0124
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0101 0.1018
Brugia malayi CHD4 protein 0.0014 0.0063 0.0161
Trichomonas vaginalis DNA polymerase eta, putative 0.0044 0.0474 0.1132
Schistosoma mansoni cpg binding protein 0.0033 0.0317 0.0309
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.084 0.0833
Plasmodium vivax cytochrome b 0.0083 0.1001 0.3998
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0762 0.0755
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0619 0.0618
Loa Loa (eye worm) hypothetical protein 0.0084 0.1019 0.2468
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0414 0.0412
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0162 0.016
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0497 0.1918
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0759 0.0757
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0277 0.062
Toxoplasma gondii apocytochrome b, putative 0.0083 0.1001 0.9814
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0162 0.016
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0025 0.0063
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0253 0.2866
Schistosoma mansoni loxhd1 0.0189 0.2455 0.2449
Brugia malayi acetyltransferase, GNAT family protein 0.0156 0.1999 0.5146
Loa Loa (eye worm) glutaminase 2 0.0293 0.3884 0.9416
Onchocerca volvulus 0.0293 0.3883 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0056
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0164 0.0163
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.084 0.0839
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0101 0.0242
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0894 0.2224
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0497 0.4709
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.009
Echinococcus multilocularis geminin 0.0182 0.2358 0.2357
Onchocerca volvulus 0.0189 0.2455 0.6314
Brugia malayi SET domain containing protein 0.0013 0.0048 0.0123
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.0624 0.0987
Brugia malayi jmjC domain containing protein 0.0063 0.0734 0.1891
Entamoeba histolytica deoxycytidyl transferase, putative 0.0016 0.0084 0.0562
Brugia malayi hypothetical protein 0.0011 0.0025 0.0063
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0101 0.0703
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0619 0.151
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0734 0.0727
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0164 0.0395
Brugia malayi nuclear receptor NHR-88 0.001 0.0008 0.0021
Echinococcus multilocularis chromobox protein 1 0.0075 0.0894 0.0892
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0063 0.0055
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0101 0.01

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 97.7 nM Inhibition of Sus scrofa (pig) heart cytochrome bc1 complex using DBH2 as substrate by spectrophotometric analysis ChEMBL. 19928849

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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