Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Arabidopsis thaliana | acetolactate synthase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.3405 | 0.3117 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.008 | 0.3485 | 0.32 |
Trichomonas vaginalis | rho3, putative | 0.0134 | 0.8696 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0076 | 0.3143 | 0.5 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | transforming protein RhoA | 0.0134 | 0.8696 | 0.8639 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.8696 | 0.8639 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0133 | 0.8542 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.8696 | 0.8639 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.008 | 0.3485 | 0.3299 |
Schistosoma mansoni | acetolactate synthase | 0.0114 | 0.6706 | 0.6562 |
Schistosoma mansoni | tyrosine kinase | 0.0148 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0133 | 0.8542 | 1 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0076 | 0.3156 | 0.2856 |
Loa Loa (eye worm) | guanine nucleotide regulatory protein | 0.0134 | 0.8696 | 0.8639 |
Echinococcus multilocularis | transforming protein RhoA | 0.0134 | 0.8696 | 0.8659 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0148 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.3485 | 0.32 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0133 | 0.8542 | 1 |
Loa Loa (eye worm) | guanine nucleotide regulatory protein | 0.0134 | 0.8696 | 0.8639 |
Echinococcus granulosus | epidermal growth factor receptor | 0.008 | 0.3485 | 0.32 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0076 | 0.3143 | 0.368 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0148 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase | 0.0076 | 0.3143 | 0.368 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0076 | 0.3143 | 1 |
Echinococcus multilocularis | transforming protein RhoA | 0.0134 | 0.8696 | 0.8659 |
Schistosoma mansoni | gtpase_rho | 0.0134 | 0.8696 | 0.8639 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0076 | 0.3143 | 0.5 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0133 | 0.8542 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0047 | 0.042 | 0.0145 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.0133 | 0.8542 | 0.8478 |
Echinococcus granulosus | transforming protein RhoA | 0.0134 | 0.8696 | 0.8639 |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.3405 | 0.3117 |
Brugia malayi | RAS-like GTP-binding protein RhoA | 0.0134 | 0.8696 | 0.8639 |
Schistosoma mansoni | Rho2 GTPase | 0.0134 | 0.8696 | 0.8639 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0076 | 0.3143 | 0.368 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0043 | 0 | 0.5 |
Entamoeba histolytica | Rho family GTPase | 0.0134 | 0.8696 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0133 | 0.8542 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0148 | 1 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0114 | 0.6706 | 0.6562 |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.3405 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.3485 | 0.32 |
Echinococcus multilocularis | insulin receptor | 0.0047 | 0.042 | 0.0145 |
Loa Loa (eye worm) | ILVBL protein | 0.008 | 0.3563 | 0.3281 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0133 | 0.8542 | 0.5 |
Brugia malayi | RAS-like GTP-binding protein RhoA | 0.0134 | 0.8696 | 0.8639 |
Onchocerca volvulus | 0.0134 | 0.8696 | 0.5 | |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0133 | 0.8542 | 1 |
Brugia malayi | RAS-like GTP-binding protein RhoA | 0.0134 | 0.8696 | 0.8639 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.36 | Inhibition of acetolactate synthase in 6-7 days old etiolated Pisum sativum (pea) shoot | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.