Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Arabidopsis thaliana | acetolactate synthase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0292 | 1 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0157 | 0.4254 | 0.32 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0133 | 0.3236 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0076 | 0.0817 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0093 | 0.1549 | 0.0145 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0133 | 0.3236 | 1 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0093 | 0.1549 | 0.0792 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.0133 | 0.3236 | 0.1996 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0292 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0157 | 0.4254 | 0.32 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0076 | 0.0817 | 0.5 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0076 | 0.0817 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0292 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0155 | 0.4183 | 0.3117 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0133 | 0.3236 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0157 | 0.4254 | 0.32 |
Schistosoma mansoni | acetolactate synthase | 0.0114 | 0.2414 | 0.1023 |
Schistosoma mansoni | tyrosine kinase | 0.0155 | 0.4183 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.0157 | 0.4254 | 0.32 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0133 | 0.3236 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0292 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0133 | 0.3236 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0114 | 0.2414 | 0.1023 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0133 | 0.3236 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0157 | 0.4254 | 0.3299 |
Mycobacterium ulcerans | hypothetical protein | 0.0133 | 0.3236 | 1 |
Loa Loa (eye worm) | ILVBL protein | 0.008 | 0.1005 | 0.0199 |
Echinococcus multilocularis | insulin receptor | 0.0093 | 0.1549 | 0.0145 |
Schistosoma mansoni | tyrosine kinase | 0.0155 | 0.4183 | 0.3117 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.65 | Inhibition of acetolactate synthase in 6-7 days old etiolated Pisum sativum (pea) shoot | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.