Detailed information for compound 1803489

Basic information

Technical information
  • TDR Targets ID: 1803489
  • Name: (4-acetylphenyl) N,N-dimethylcarbamate
  • MW: 207.226 | Formula: C11H13NO3
  • H donors: 0 H acceptors: 2 LogP: 1.37 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N(C)C)Oc1ccc(cc1)C(=O)C
  • InChi: 1S/C11H13NO3/c1-8(13)9-4-6-10(7-5-9)15-11(14)12(2)3/h4-7H,1-3H3
  • InChiKey: DZOXLGLBCHWNCQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,N-dimethylcarbamic acid (4-acetylphenyl) ester
  • (4-ethanoylphenyl) N,N-dimethylcarbamate
  • ZINC00317871

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0083 0.0078 0.0293
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.012 0.0128 0.0212
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0108 0.0111 0.0183
Loa Loa (eye worm) hypothetical protein 0.0113 0.0118 0.0114
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0043 0.0024 0.0027
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0619 0.0795 0.2707
Loa Loa (eye worm) aspartyl protease 6 0.012 0.0128 0.0123
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0079 0.0072 0.0269
Schistosoma mansoni furin-1 (S08 family) 0.075 0.097 0.1657
Brugia malayi Integrin alpha pat-2 precursor 0.1569 0.2065 0.2065
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0118 0.0125 0.0364
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0067 0.0056 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0317 0.039 0.1396
Echinococcus granulosus neuroendocrine convertase 2 0.1067 0.1393 0.1885
Giardia lamblia High cysteine membrane protein Group 2 0.0608 0.078 1
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0111 0.034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.012 0.0128 0.0212
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0078 0.0071 0.0265
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0425 0.0534 0.091
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0118 0.0125 0.0408
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0108 0.0111 0.0415
Schistosoma mansoni site-1 peptidase (S08 family) 0.0108 0.0111 0.0183
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0113 0.0118 0.0195
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0068 0.0057 0.0211
Plasmodium falciparum plasmepsin VI 0.0231 0.0275 0.0663
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0273 0.0331 0.1243
Schistosoma mansoni cathepsin D (A01 family) 0.0513 0.0653 0.1113
Schistosoma mansoni integrin alpha-ps 0.0789 0.1022 0.1748
Plasmodium falciparum subtilisin-like protease 2 0.0108 0.0111 0.0073
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.012 0.0128 0.0212
Mycobacterium leprae conserved hypothetical protein 0.016 0.0181 0.0676
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0046 0.0028 0.0106
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0273 0.0331 0.1127
Echinococcus granulosus integrin alpha ps 0.0378 0.0473 0.0636
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Echinococcus granulosus membrane bound transcription factor site 1 0.0108 0.0111 0.0145
Toxoplasma gondii aspartyl protease ASP3 0.012 0.0128 0.0371
Loa Loa (eye worm) hypothetical protein 0.0067 0.0056 0.0052
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.218 0.2881 0.4939
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.0031 0.0036
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0032 0.0009 0.0007
Brugia malayi Disintegrin family protein 0.01 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.078 0.1009 0.1005
Brugia malayi Reprolysin 0.0141 0.0156 0.0156
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0021 0.0046
Mycobacterium ulcerans Type I modular polyketide synthase 0.0078 0.0071 0.0267
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0045
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0118 0.0125 0.0468
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0273 0.0331 0.0444
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.033 0.0408 0.0548
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0273 0.0331 0.1084
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0078 0.0071 0.0267
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0118 0.0125 0.0364
Brugia malayi hypothetical protein 0.012 0.0128 0.0128
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0048 0.0031 0.0036
Echinococcus granulosus dna polymerase kappa 0.004 0.0021 0.0022
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0021 0.0046
Plasmodium falciparum plasmepsin I 0.0231 0.0275 0.0663
Mycobacterium ulcerans Type I modular polyketide synthase 0.0078 0.0071 0.0267
Plasmodium vivax subtilisin-like protease 1 0.0611 0.0784 0.2484
Loa Loa (eye worm) hypothetical protein 0.1153 0.1508 0.1505
Plasmodium falciparum subtilisin-like protease 3 0.0108 0.0111 0.0073
Brugia malayi aspartic protease BmAsp-1, identical 0.012 0.0128 0.0128
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0269 0.0326 0.0437
Loa Loa (eye worm) hypothetical protein 0.044 0.0555 0.0551
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0021 0.0046
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0043 0.0024 0.0027
Echinococcus granulosus furin 0.1675 0.2207 0.299
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0097 0.0097
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.218 0.2881 1
Loa Loa (eye worm) aspartic protease BmAsp-1 0.012 0.0128 0.0123
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.0272 0.0459
Loa Loa (eye worm) hypothetical protein 0.0397 0.0497 0.0493
Plasmodium vivax aspartyl proteinase, putative 0.012 0.0128 0.0134
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0397 0.0497 0.0497
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0243 0.0292 0.0494
Echinococcus multilocularis dna polymerase kappa 0.004 0.0021 0.0022
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0009 0.0009
Loa Loa (eye worm) integrin alpha pat-2 0.2227 0.2945 0.2941
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0062 0.005 0.0185
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.218 0.2881 1
Echinococcus multilocularis disintegrin and metalloproteinase 0.01 0.01 0.013
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.2019 0.2667 1
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0111 0.034
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0273 0.0331 0.0864
Mycobacterium ulcerans Type I modular polyketide synthase 0.0078 0.0071 0.0267
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0021 0.0046
Loa Loa (eye worm) hypothetical protein 0.01 0.01 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0021 0.0046
Loa Loa (eye worm) acyl carrier protein 0.0037 0.0017 0.0012
Brugia malayi celfurPC protein 0.1359 0.1783 0.1783
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0108 0.0111 0.0145
Brugia malayi neuroendocrine convertase 1 precursor 0.1067 0.1393 0.1393
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0056 0.0056
Onchocerca volvulus 0.012 0.0128 0.6969
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0032 0.0009 0.0007
Echinococcus granulosus glutamate receptor subunit protein glur 0.0032 0.0009 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0021 0.0046
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.0031 0.0036
Loa Loa (eye worm) hypothetical protein 0.012 0.0128 0.0123
Loa Loa (eye worm) hypothetical protein 0.0067 0.0056 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0317 0.039 0.1396
Echinococcus granulosus Furin 1 0.0425 0.0534 0.0719
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0033 0.0011 0.0039
Echinococcus granulosus disintegrin and metalloproteinase 0.01 0.01 0.013
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.011 0.0114 0.0114
Brugia malayi Glutamate receptor 2 precursor 0.0032 0.0009 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.218 0.2881 0.3905
Plasmodium falciparum plasmepsin III 0.012 0.0128 0.0134
Brugia malayi aspartic protease BmAsp-2, identical 0.012 0.0128 0.0128
Mycobacterium ulcerans polyketide synthase 0.0078 0.0071 0.0267
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.218 0.2881 1
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0043 0.0024 0.0027
Toxoplasma gondii aspartyl protease ASP1 0.0231 0.0275 0.0888
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.2019 0.2667 1
Schistosoma mansoni cathepsin D (A01 family) 0.0513 0.0653 0.1113
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0273 0.0331 0.1127
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.218 0.2881 1
Mycobacterium leprae Polyketide synthase Pks13 0.0118 0.0125 0.0466
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0078 0.0071 0.0267
Schistosoma mansoni hypothetical protein 0.0113 0.0118 0.0195
Toxoplasma gondii subtilisin SUB6 0.0108 0.0111 0.0312
Loa Loa (eye worm) glutamate receptor 2 0.0032 0.0009 0.0005
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0051 0.0035 0.0127
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0078 0.0071 0.0071
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0425 0.0534 0.1941
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0032 0.0009 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0317 0.039 0.1396
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0078 0.0071 0.0265
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0053 0.0037 0.0054
Plasmodium falciparum subtilisin-like protease 1 0.0611 0.0784 0.2484
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0078 0.0071 0.0267
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0068 0.0068
Schistosoma mansoni protein kinase 0.0126 0.0135 0.0224
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0241 0.0289 0.0489
Plasmodium falciparum plasmepsin II 0.0231 0.0275 0.0663
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0108 0.0111 0.0111
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Toxoplasma gondii type I fatty acid synthase, putative 0.0058 0.0044 0.0078
Toxoplasma gondii hypothetical protein 0.016 0.0181 0.0558
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.0031 0.0036
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.016 0.0181 0.0606
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0118 0.0125 0.0468
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0083 0.0078 0.029
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.218 0.2881 0.2881
Loa Loa (eye worm) hypothetical protein 0.016 0.0181 0.0177
Brugia malayi Death domain containing protein 0.0028 0.0004 0.0004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0425 0.0534 0.1941
Trypanosoma cruzi subtilisin peptidase 0.0108 0.0111 0.0315
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0231 0.0275 0.0368
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0108 0.0111 0.0415
Brugia malayi Eukaryotic aspartyl protease family protein 0.012 0.0128 0.0128
Plasmodium falciparum plasmepsin IX 0.012 0.0128 0.0134
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN) 0.0092 0.009 0.0336
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0113 0.0118 0.0154
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0108 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0317 0.039 0.0662
Echinococcus multilocularis integrin beta 2 0.5537 0.737 1
Brugia malayi hypothetical protein 0.1153 0.1508 0.1508
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0273 0.0331 0.0796
Loa Loa (eye worm) hypothetical protein 0.0133 0.0145 0.0141
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.0031 0.0036
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0114 0.0119 0.0155
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.1033 0.1348 0.1824
Trichomonas vaginalis conserved hypothetical protein 0.0317 0.039 0.1396
Echinococcus multilocularis integrin alpha ps 0.0378 0.0473 0.0636
Plasmodium vivax plasmepsin IV, putative 0.0231 0.0275 0.0663
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0231 0.0275 0.0368
Loa Loa (eye worm) hypothetical protein 0.0642 0.0825 0.0821
Echinococcus granulosus integrin alpha 3 0.1158 0.1515 0.2051
Brugia malayi Pepsin A precursor 0.012 0.0128 0.0128
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1033 0.1348 0.5016
Mycobacterium ulcerans polyketide synthase 0.0083 0.0078 0.0293
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0317 0.039 0.1396
Brugia malayi Kelch motif family protein 0.1164 0.1522 0.1522
Echinococcus granulosus adam 17 protease 0.01 0.01 0.013
Echinococcus multilocularis nmda type glutamate receptor 0.0114 0.0119 0.0155
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0082 0.0076 0.0285
Loa Loa (eye worm) proprotein convertase 2 0.0425 0.0534 0.053
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0108 0.0111 0.0415
Toxoplasma gondii subtilisin SUB7 0.0108 0.0111 0.0312
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0108 0.0111 0.0415
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.1033 0.1348 0.1824
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0097 0.0092
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0273 0.0331 0.0864
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0273 0.0331 0.1086
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0012 0.0016
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit beta 0.0092 0.009 0.0339
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.2019 0.2667 1
Schistosoma mansoni hypothetical protein 0.0067 0.0056 0.0088
Toxoplasma gondii subtilisin SUB2 0.0108 0.0111 0.0312
Plasmodium vivax aspartyl proteinase, putative 0.0231 0.0275 0.0663
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0231 0.0275 0.0962
Plasmodium vivax subtilisin-like serine protease, putative 0.0108 0.0111 0.0073
Schistosoma mansoni tumor necrosis factor receptor related 0.0043 0.0024 0.0034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0273 0.0331 0.0562
Loa Loa (eye worm) hypothetical protein 0.0231 0.0275 0.0271
Plasmodium falciparum plasmepsin VIII, putative 0.012 0.0128 0.0134
Schistosoma mansoni hypothetical protein 0.0113 0.0118 0.0195
Schistosoma mansoni integrin alpha 0.1569 0.2065 0.3538
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0111 0.034
Schistosoma mansoni glutamate receptor AMPA 0.0032 0.0009 0.0009
Loa Loa (eye worm) endoprotease bli-4 0.1675 0.2207 0.2203
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1339 0.1757 0.3009
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0108 0.0111 0.0415
Loa Loa (eye worm) hypothetical protein 0.0074 0.0066 0.0062
Brugia malayi polk-prov protein 0.0031 0.0008 0.0008
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0032 0.0009 0.0007
Brugia malayi angiogenesis inhibito 0.0141 0.0155 0.0155
Toxoplasma gondii subtilisin SUB12 0.0108 0.0111 0.0312
Loa Loa (eye worm) hypothetical protein 0.016 0.0181 0.0177
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0273 0.0331 0.1243
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0113 0.0118 0.0118
Echinococcus multilocularis NMDA receptor 0.0032 0.0009 0.0007
Echinococcus multilocularis adam 0.0476 0.0603 0.0813
Mycobacterium tuberculosis Probable thioesterase TesA 0.0068 0.0057 0.0214
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0079 0.0072 0.0269
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0043 0.0024 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0021 0.0046
Loa Loa (eye worm) hypothetical protein 0.1098 0.1435 0.1431
Loa Loa (eye worm) glutamate receptor 1 0.0032 0.0009 0.0005
Loa Loa (eye worm) hypothetical protein 0.0473 0.0599 0.0595
Toxoplasma gondii subtilisin SUB4 0.0108 0.0111 0.0312
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.218 0.2881 1
Echinococcus granulosus nmda type glutamate receptor 0.0114 0.0119 0.0155
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Schistosoma mansoni hypothetical protein 0.0031 0.0008 0.0006
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0032 0.0009 0.0007
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0141 0.0155 0.0151
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0025 0.0001 0.0003
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0083 0.0078 0.0293
Plasmodium falciparum plasmepsin VII 0.012 0.0128 0.0134
Toxoplasma gondii type I fatty acid synthase, putative 0.0083 0.0078 0.0198
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.218 0.2881 1
Brugia malayi EGF-like domain containing protein 0.016 0.0181 0.0181
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0021 0.0046
Loa Loa (eye worm) integrin beta-2 0.7504 1 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0126 0.0135 0.0177
Brugia malayi EGF-like domain containing protein 0.016 0.0181 0.0181
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0273 0.0331 0.1086
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0008 0.0004
Schistosoma mansoni dihydroceramide desaturase 0.01 0.01 0.0165
Loa Loa (eye worm) hypothetical protein 0.1191 0.1559 0.1555
Echinococcus multilocularis Furin 1 0.0425 0.0534 0.0719
Mycobacterium ulcerans polyketide synthase Pks13 0.0118 0.0125 0.0468
Schistosoma mansoni apoptosis regulator bax 0.0113 0.0118 0.0195
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1098 0.1435 0.1435
Loa Loa (eye worm) fatty acid synthase 0.008 0.0074 0.0069
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.218 0.2881 0.3905
Echinococcus granulosus GPCR family 2 0.0031 0.0008 0.0005
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0076 0.0068 0.0255
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.0031 0.0036
Brugia malayi proprotein convertase 2 0.1067 0.1393 0.1393
Mycobacterium leprae Possible secreted protease 0.0108 0.0111 0.0413
Trichomonas vaginalis hypothetical protein 0.016 0.0181 0.0606
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0048 0.0031 0.0036
Plasmodium vivax aspartyl protease, putative 0.012 0.0128 0.0134
Schistosoma mansoni site-1 peptidase (S08 family) 0.0108 0.0111 0.0183
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0083 0.0078 0.029
Trichomonas vaginalis conserved hypothetical protein 0.0317 0.039 0.1396
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0058 0.0045 0.0167
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.2019 0.2667 1
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0273 0.0331 0.1127
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0317 0.039 0.1396
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.218 0.2881 0.2878
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.016 0.0181 0.0679
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0273 0.0331 0.0444
Schistosoma mansoni ATP-binding cassette transporter 0.0033 0.0011 0.0011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Plasmodium falciparum plasmepsin X 0.012 0.0128 0.0134
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0078 0.0071 0.0267
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0083 0.0078 0.0293
Loa Loa (eye worm) apoptosis regulator protein 0.0113 0.0118 0.0114
Schistosoma mansoni protein kinase 0.0126 0.0135 0.0224
Chlamydia trachomatis transcriptional repressor NrdR 0.016 0.0181 0.0375
Mycobacterium leprae Probable polyketide synthase Pks1 0.0083 0.0078 0.029
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0083 0.0078 0.0293
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.01 0.01 0.013
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0317 0.039 0.1396
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0231 0.0275 0.0888
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0425 0.0534 0.1941
Mycobacterium ulcerans transcriptional regulator NrdR 0.016 0.0181 0.0679
Plasmodium falciparum plasmepsin V 0.012 0.0128 0.0134
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0425 0.0534 0.1941
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.0031 0.0036
Loa Loa (eye worm) kelch domain-containing protein family protein 0.1164 0.1522 0.1519
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0316 0.0389 0.066
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0108 0.0111 0.0415
Schistosoma mansoni glutamate receptor AMPA 0.0032 0.0009 0.0009
Toxoplasma gondii subtilisin SUB10 0.0108 0.0111 0.0312
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0004 0.0004
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1675 0.2207 0.3781
Schistosoma mansoni hypothetical protein 0.0113 0.0118 0.0195
Echinococcus granulosus fibrillin 1 0.016 0.0181 0.024
Plasmodium vivax subtilisin-like protease 2, putative 0.0108 0.0111 0.0073
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0108 0.0111 0.0315
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0425 0.0534 0.1941
Brugia malayi ADAMTS-like protease 0.0141 0.0155 0.0155
Toxoplasma gondii subtilisin SUB5 0.0108 0.0111 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0317 0.039 0.1396
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.033 0.0408 0.0548
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.218 0.2881 1
Loa Loa (eye worm) metalloprotease 0.0067 0.0056 0.0052
Mycobacterium ulcerans thioesterase 0.0068 0.0057 0.0214
Toxoplasma gondii aspartyl protease 0.012 0.0128 0.0371
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Echinococcus multilocularis GPCR, family 2 0.0031 0.0008 0.0005
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0228 0.0272 0.0268
Mycobacterium ulcerans fatty acid synthase Fas 0.0025 0.0001 0.0003
Echinococcus multilocularis glutamate receptor 2 0.0048 0.0031 0.0036
Echinococcus multilocularis integrin alpha 3 0.1158 0.1515 0.2051
Brugia malayi Subtilase family protein 0.0108 0.0111 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0021 0.0046
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0025 0 0.0001
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0032 0.0009 0.0007
Schistosoma mansoni hypothetical protein 0.0032 0.0009 0.0009
Echinococcus multilocularis neuroendocrine convertase 2 0.1067 0.1393 0.1885
Loa Loa (eye worm) subtilase 0.0108 0.0111 0.0106
Onchocerca volvulus 0.0076 0.0068 0.3599
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0021 0.0078
Schistosoma mansoni glutamate receptor NMDA 0.0269 0.0326 0.0553
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.012 0.0128 0.0212
Plasmodium falciparum plasmepsin IV 0.0231 0.0275 0.0663
Schistosoma mansoni memapsin-2 (A01 family) 0.2177 0.2878 0.4934
Echinococcus multilocularis fibrillin 2 0.016 0.0181 0.024
Brugia malayi hypothetical protein 0.0316 0.0389 0.0389
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0111 0.034
Trichomonas vaginalis conserved hypothetical protein 0.0317 0.039 0.1396
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0241 0.0289 0.0489
Loa Loa (eye worm) hypothetical protein 0.0031 0.0008 0.0004
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0726 0.0937 0.3515
Onchocerca volvulus 0.0141 0.0155 0.8544
Brugia malayi Stress-activated protein kinase jnk-1 0.0228 0.0272 0.0272
Echinococcus multilocularis glutamate receptor 2 0.0032 0.0009 0.0007
Echinococcus granulosus integrin beta 2 0.5537 0.737 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0126 0.0135 0.0177
Loa Loa (eye worm) hypothetical protein 0.016 0.0181 0.0177
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0231 0.0275 0.0271
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0062 0.005 0.0188
Brugia malayi Glutamate receptor 1 precursor 0.0032 0.0009 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0008 0.0008
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0273 0.0331 0.1127
Toxoplasma gondii subtilisin SUB8 0.0108 0.0111 0.0312
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0008 0.0005
Toxoplasma gondii subtilisin SUB11 0.0108 0.0111 0.0312
Trichomonas vaginalis hypothetical protein 0.0317 0.039 0.1396
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.012 0.0128 0.0371
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0008 0.0008
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0273 0.0331 0.0327
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.012 0.0128 0.0212
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1033 0.1348 0.5016
Schistosoma mansoni protein kinase 0.0126 0.0135 0.0224
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0021 0.0046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0111 0.034
Echinococcus multilocularis fibrillin 1 0.016 0.0181 0.024
Schistosoma mansoni glutamate receptor NMDA 0.0048 0.0031 0.0046
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.218 0.2881 1
Onchocerca volvulus 0.016 0.0181 1
Brugia malayi hypothetical protein 0.012 0.0128 0.0128
Trypanosoma brucei subtilisin peptidase 0.0108 0.0111 0.0359
Plasmodium vivax aspartyl protease, putative 0.012 0.0128 0.0134
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0151 0.0168 0.0168
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0273 0.0331 0.0796
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.1416 0.186 0.2519
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.01 0.01 0.013
Mycobacterium ulcerans thioesterase TesA 0.0068 0.0057 0.0214
Onchocerca volvulus 0.012 0.0128 0.6969
Schistosoma mansoni integrin beta subunit 0.4384 0.5829 1
Mycobacterium ulcerans polyketide synthase Pks9 0.0051 0.0035 0.013
Echinococcus granulosus c-Jun N-terminal kinases 0.0228 0.0272 0.0363
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0108 0.0111 0.0145
Loa Loa (eye worm) hypothetical protein 0.0031 0.0008 0.0003
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0108 0.0111 0.0413
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Echinococcus multilocularis protein jagged 2 0.016 0.0181 0.024
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.012 0.0128 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0317 0.039 0.1396
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0092 0.009 0.0288
Treponema pallidum ribonucleotide-diphosphate reductase subunit beta 0.0273 0.0331 0.0911
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0108 0.0111 0.0413
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0008 0.0005
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.1416 0.186 0.2519
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0241 0.0289 0.0387
Brugia malayi Protein kinase domain containing protein 0.0029 0.0005 0.0005
Plasmodium vivax plasmepsin V, putative 0.012 0.0128 0.0134
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0021 0.0078
Onchocerca volvulus Fatty acid synthase homolog 0.0146 0.0162 0.8924
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0113 0.0118 0.0154
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0063 0.0052 0.0193
Onchocerca volvulus 0.0108 0.0111 0.6021
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0076 0.0068 0.0064
Loa Loa (eye worm) hypothetical protein 0.016 0.0181 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0021 0.0046
Echinococcus granulosus glutamate receptor 2 0.0048 0.0031 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0317 0.039 0.1396
Echinococcus granulosus fibrillin 2 0.016 0.0181 0.024
Schistosoma mansoni hypothetical protein 0.0378 0.0473 0.0804
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0082 0.0076 0.0285
Brugia malayi Uncoordinated protein 44 0.0028 0.0004 0.0004
Brugia malayi metalloprotease 0.0067 0.0056 0.0056
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.012 0.0128 0.0212
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit beta 0.0273 0.0331 0.0911
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0231 0.0275 0.0465
Loa Loa (eye worm) hypothetical protein 0.0241 0.0289 0.0285
Echinococcus granulosus glutamate NMDA receptor subunit 0.0269 0.0326 0.0437
Loa Loa (eye worm) hypothetical protein 0.1675 0.2207 0.2203
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0241 0.0289 0.0387
Brugia malayi ribonucleotide reductase 2 0.0273 0.0331 0.0331
Echinococcus multilocularis integrin alpha ps 0.0789 0.1022 0.1382
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.2019 0.2667 1
Schistosoma mansoni hypothetical protein 0.0031 0.0008 0.0006
Brugia malayi EGF-like domain containing protein 0.016 0.0181 0.0181
Echinococcus granulosus integrin alpha ps 0.0851 0.1105 0.1494
Brugia malayi Guanylate kinase family protein 0.0026 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0108 0.0111 0.0106
Schistosoma mansoni integrin alpha-ps 0.0473 0.0599 0.1021
Giardia lamblia Furin precursor putative serine protease 0.0317 0.039 0.3489
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0083 0.0078 0.0293
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0317 0.039 0.1396
Loa Loa (eye worm) reprolysin 0.0241 0.0289 0.0285
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0108 0.0111 0.0415
Loa Loa (eye worm) angiogenesis inhibito 0.0067 0.0056 0.0052
Echinococcus multilocularis 0.1359 0.1783 0.2415
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0108 0.0111 0.0183
Schistosoma mansoni hypothetical protein 0.0031 0.0008 0.0006
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.012 0.0128 0.0212
Brugia malayi ADAM-TS Spacer 1 family protein 0.0141 0.0155 0.0155
Echinococcus granulosus adam 0.0476 0.0603 0.0813
Loa Loa (eye worm) hypothetical protein 0.0043 0.0024 0.0019
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0051 0.0035 0.013
Toxoplasma gondii subtilisin SUB1 0.0611 0.0784 0.2665
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0228 0.0272 0.0363
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Trichomonas vaginalis conserved hypothetical protein 0.0317 0.039 0.1396
Loa Loa (eye worm) hypothetical protein 0.012 0.0128 0.0123
Brugia malayi endoprotease bli-4 precursor 0.1675 0.2207 0.2207
Plasmodium vivax aspartyl protease, putative 0.012 0.0128 0.0134
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.011 0.0114 0.0109
Toxoplasma gondii subtilisin SUB9 0.0108 0.0111 0.0312
Trypanosoma brucei unspecified product 0.0034 0.0012 0.0016
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0111 0.034
Echinococcus multilocularis membrane bound transcription factor site 1 0.0108 0.0111 0.0145
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0062 0.005 0.0188
Echinococcus multilocularis integrin alpha ps 0.0851 0.1105 0.1494
Brugia malayi EGF-like domain containing protein 0.016 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0141 0.0155 0.0151
Schistosoma mansoni hypothetical protein 0.0031 0.0008 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0425 0.0534 0.1941

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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