Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Gamma-amino-N-butyrate transaminase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | 4-aminobutyrate aminotransferase, mitochondrial precursor | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Mycobacterium ulcerans | L-lysine aminotransferase | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Mycobacterium tuberculosis | Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Candida albicans | one of two potential aminotransferase genes similar to S. cerevisiae UGA1 (YGR019W) gamma-aminobutyrate (GABA) transaminase | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Candida albicans | one of two potential aminotransferase genes | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Candida albicans | one of two potential aminotransferase genes | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Galactoside-binding lectin family protein | 0.0039 | 0.0341 | 0.0341 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0106 | 0.2892 | 1 |
Loa Loa (eye worm) | galectin | 0.0039 | 0.0341 | 0.1178 |
Brugia malayi | Galactoside-binding lectin family protein | 0.0039 | 0.0341 | 0.0341 |
Mycobacterium tuberculosis | Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) | 0.0293 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0341 | 0.1178 |
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.0039 | 0.0341 | 0.1178 |
Mycobacterium ulcerans | L-lysine aminotransferase | 0.0293 | 1 | 0.5 |
Brugia malayi | Galactoside-binding lectin family protein | 0.0039 | 0.0341 | 0.0341 |
Brugia malayi | galectin | 0.0039 | 0.0341 | 0.0341 |
Brugia malayi | galectin | 0.0039 | 0.0341 | 0.0341 |
Echinococcus granulosus | geminin | 0.0165 | 0.5111 | 1 |
Onchocerca volvulus | Galectin homolog | 0.0039 | 0.0341 | 0.5 |
Echinococcus multilocularis | geminin | 0.0165 | 0.5111 | 1 |
Onchocerca volvulus | Galectin homolog | 0.0039 | 0.0341 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0044 | 0.0535 | 0.1849 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0106 | 0.2892 | 1 |
Brugia malayi | Galactoside-binding lectin family protein | 0.0039 | 0.0341 | 0.0341 |
Brugia malayi | MH2 domain containing protein | 0.0106 | 0.2892 | 0.2892 |
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.0039 | 0.0341 | 0.1178 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0535 | 0.1849 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5111 | 1 |
Loa Loa (eye worm) | galectin | 0.0039 | 0.0341 | 0.1178 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0044 | 0.0535 | 0.0535 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0341 | 0.1178 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5111 | 1 |
Schistosoma mansoni | galectin | 0.0039 | 0.0341 | 0.0667 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0341 | 0.1178 |
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.0039 | 0.0341 | 0.1178 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0044 | 0.0535 | 0.0535 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.14 uM | Inhibition of Rattus norvegicus (rat) brain gamma-amino butyrate aminotransferase using gamma-amino butyrate as substrate assessed as decrease in NADPH generation after 30 min by spectrophotometric analysis | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.