Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Arabidopsis thaliana | acetolactate synthase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0056 | 0.1489 | 0.5 |
Onchocerca volvulus | 0.0056 | 0.1489 | 0.5 | |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0056 | 0.1489 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0056 | 0.1489 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0056 | 0.1489 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0056 | 0.1489 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0056 | 0.1489 | 0.5 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0043 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0133 | 1 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0076 | 0.368 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0056 | 0.1489 | 0.5 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0076 | 0.368 | 0.368 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0056 | 0.1489 | 0.5 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0133 | 1 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0114 | 0.7851 | 1 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0133 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0056 | 0.1489 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0056 | 0.1489 | 0.5 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0056 | 0.1489 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0056 | 0.1489 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0056 | 0.1489 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0133 | 1 | 1 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0133 | 1 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0056 | 0.1489 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0056 | 0.1489 | 0.5 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0056 | 0.1489 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0056 | 0.1489 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0133 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0056 | 0.1489 | 0.5 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0043 | 0 | 0.5 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0076 | 0.368 | 1 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0076 | 0.368 | 0.368 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0076 | 0.3694 | 0.8221 |
Mycobacterium ulcerans | acetolactate synthase | 0.0076 | 0.368 | 0.368 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0056 | 0.1489 | 0.5 |
Loa Loa (eye worm) | ILVBL protein | 0.008 | 0.4171 | 1 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0133 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0056 | 0.1489 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0076 | 0.368 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0114 | 0.7851 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0056 | 0.1489 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.62 | Inhibition of acetolactate synthase in 6-7 days old etiolated Pisum sativum (pea) shoot | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.