Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Arabidopsis thaliana | acetolactate synthase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3306 | 0.5421 |
Echinococcus multilocularis | neuroglian | 0.0049 | 0.212 | 0.4393 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0076 | 0.4677 | 0.368 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0051 | 0.2377 | 0.5607 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0076 | 0.4689 | 0.8969 |
Echinococcus granulosus | neuroglian | 0.0049 | 0.212 | 0.4393 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0039 | 0.1192 | 0.1455 |
Schistosoma mansoni | vesicular amine transporter | 0.0039 | 0.1192 | 0.1455 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0043 | 0.1578 | 0.5 |
Loa Loa (eye worm) | ILVBL protein | 0.008 | 0.5091 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0114 | 0.819 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3306 | 0.5421 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0133 | 1 | 0.5 |
Echinococcus multilocularis | roundabout 2 | 0.0061 | 0.3306 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0076 | 0.4677 | 0.5 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0076 | 0.4677 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0133 | 1 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0051 | 0.2377 | 0.2902 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.2377 | 0.304 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0039 | 0.1192 | 0.1455 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0133 | 1 | 0.5 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0043 | 0.1578 | 0.5 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0055 | 0.2707 | 0.3887 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0133 | 1 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0043 | 0.1578 | 0.5 |
Echinococcus granulosus | twitchin | 0.0049 | 0.212 | 0.4393 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0133 | 1 | 1 |
Schistosoma mansoni | nephrin | 0.0049 | 0.212 | 0.2589 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0133 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase | 0.0076 | 0.4677 | 0.368 |
Echinococcus granulosus | roundabout 2 | 0.0061 | 0.3306 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0114 | 0.819 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0055 | 0.2707 | 0.1721 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0076 | 0.4677 | 0.368 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0043 | 0.1578 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0076 | 0.4677 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.67 | Inhibition of acetolactate synthase in 6-7 days old etiolated Pisum sativum (pea) shoot | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.