Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Arabidopsis thaliana | acetolactate synthase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0043 | 0 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0101 | 0.6491 | 0.4857 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.7799 | 1 |
Schistosoma mansoni | nephrin | 0.009 | 0.5206 | 0.6368 |
Schistosoma mansoni | acetolactate synthase | 0.0114 | 0.7851 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0133 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase | 0.0076 | 0.368 | 0.368 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0076 | 0.3694 | 0.1121 |
Schistosoma mansoni | vesicular amine transporter | 0.0071 | 0.3176 | 0.3579 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0133 | 1 | 1 |
Echinococcus granulosus | neuroglian | 0.009 | 0.5206 | 0.4393 |
Echinococcus granulosus | roundabout 2 | 0.0113 | 0.7799 | 1 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0133 | 1 | 0.5 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0071 | 0.3176 | 0.3579 |
Loa Loa (eye worm) | ILVBL protein | 0.008 | 0.4171 | 0.2153 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0043 | 0 | 0.5 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0133 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0133 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.5768 | 0.5607 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0076 | 0.368 | 0.368 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0076 | 0.368 | 0.368 |
Schistosoma mansoni | acetolactate synthase | 0.0114 | 0.7851 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0095 | 0.5768 | 0.714 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.7799 | 1 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0133 | 1 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0113 | 0.7799 | 1 |
Echinococcus granulosus | twitchin | 0.009 | 0.5206 | 0.4393 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0076 | 0.368 | 0.5 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0071 | 0.3176 | 0.3579 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0043 | 0 | 0.5 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | neuroglian | 0.009 | 0.5206 | 0.4393 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0076 | 0.368 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0095 | 0.5768 | 0.5607 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0076 | 0.368 | 0.5 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0101 | 0.6491 | 0.717 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.57 | Inhibition of acetolactate synthase in 6-7 days old etiolated Pisum sativum (pea) shoot | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.