Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.0034 | 0.4321 | 0.4321 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.5569 | 0.5569 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.5569 | 0.5569 |
Mycobacterium leprae | Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) | 0.0038 | 0.5318 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.5569 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0034 | 0.4321 | 0.776 |
Entamoeba histolytica | protein kinase, putative | 0.0034 | 0.4321 | 0.4321 |
Loa Loa (eye worm) | transcriptional regulator | 0.0018 | 0 | 0.5 |
Toxoplasma gondii | histone deacetylase SIR2 | 0.0055 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.5569 | 0.5569 |
Mycobacterium tuberculosis | Transcriptional regulatory protein | 0.0055 | 1 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0055 | 1 | 1 |
Trypanosoma cruzi | Silent information regulator 2 related protein 3 | 0.0055 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.5569 | 0.5569 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0055 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.5569 | 0.5569 |
Echinococcus granulosus | serine:threonine protein kinase Chk2 | 0.0034 | 0.4321 | 0.776 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0034 | 0.4321 | 0.4321 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | transcriptional regulator | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.5569 | 1 |
Plasmodium falciparum | transcriptional regulatory protein sir2a | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0 | 0.5 |
Giardia lamblia | Transcriptional regulator, Sir2 family | 0.0055 | 1 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0034 | 0.4318 | 0.7753 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | transcriptional regulator | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0034 | 0.4318 | 0.7753 |
Mycobacterium ulcerans | NAD-dependent deacetylase | 0.0055 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0039 | 0.5569 | 1 |
Trypanosoma brucei | Silent information regulator 2 related protein 3 | 0.0055 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.5569 | 0.5569 |
Plasmodium vivax | NAD-dependent deacetylase, putative | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | sirtuin 4 | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | Silent information regulator 2 related protein 3 | 0.0055 | 1 | 1 |
Leishmania major | NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe | 0.0055 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.