TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 293.213 | Formula: C11H14Cl2N2OS
H donors: 1 H acceptors: 0 LogP: 4.78 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCO/N=C/Nc1cc(Cl)c(c(c1)Cl)SCC
InChi: 1S/C11H14Cl2N2OS/c1-3-16-15-7-14-8-5-9(12)11(17-4-2)10(13)6-8/h5-7H,3-4H2,1-2H3,(H,14,15)
InChiKey: FLCSRWBWCAUOMP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable short-chain dehydrogenase/reductase	0.0046	0.3082	0.5
Mycobacterium ulcerans	dehydrogenase	0.0046	0.3082	0.5
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0046	0.3082	0.5
Mycobacterium tuberculosis	Possible iron-regulated short-chain dehydrogenase/reductase	0.0046	0.3082	0.5
Mycobacterium ulcerans	short-chain membrane-associated dehydrogenase	0.0046	0.3082	0.5
Onchocerca volvulus	Sepiapterin reductase homolog	0.0046	0.3082	0.5
Mycobacterium ulcerans	oxidoreductase	0.0046	0.3082	0.5
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0046	0.3082	0.5
Onchocerca volvulus		0.0046	0.3082	0.5
Echinococcus multilocularis	histone deacetylase 6	0.0057	0.5816	0.3952
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0046	0.3082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0046	0.3082	0.5
Echinococcus multilocularis	histone deacetylase 6	0.0057	0.5816	0.3952
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0046	0.3082	0.5
Echinococcus granulosus	histone deacetylase 3	0.0074	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Trypanosoma brucei	histone deacetylase 1	0.0074	1	1
Plasmodium falciparum	histone deacetylase 2	0.0057	0.5816	0.3952
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0046	0.3082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	1	1
Loa Loa (eye worm)	oxidoreductase	0.0046	0.3082	0.3082
Trypanosoma brucei	histone deacetylase 3	0.0057	0.5816	0.3952
Toxoplasma gondii	histone deacetylase HDAC2	0.0074	1	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0046	0.3082	0.5
Onchocerca volvulus		0.0046	0.3082	0.5
Trypanosoma cruzi	histone deacetylase 1, putative	0.0074	1	1
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0074	1	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0046	0.3082	0.5
Schistosoma mansoni	histone deacetylase 4 5	0.0057	0.5816	0.3952
Trichomonas vaginalis	histone deacetylase, putative	0.0074	1	1
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0046	0.3082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Echinococcus granulosus	histone deacetylase 6	0.0057	0.5816	0.3952
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0046	0.3082	0.5
Echinococcus multilocularis	histone deacetylase 3	0.0074	1	1
Mycobacterium ulcerans	short-chain dehydrogenase	0.0046	0.3082	0.5
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0046	0.3082	0.5
Trypanosoma cruzi	histone deacetylase, putative	0.0057	0.5816	0.3952
Loa Loa (eye worm)	histone deacetylase	0.0057	0.5816	0.5816
Loa Loa (eye worm)	oxidoreductase	0.0046	0.3082	0.3082
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0046	0.3082	0.5
Trypanosoma cruzi	histone deacetylase, putative	0.0057	0.5816	0.3952
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0046	0.3082	0.5
Loa Loa (eye worm)	oxidoreductase	0.0046	0.3082	0.3082
Mycobacterium tuberculosis	Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1	0.0046	0.3082	0.5
Mycobacterium ulcerans	dehydrogenase/reductase	0.0046	0.3082	0.5
Trypanosoma cruzi	histone deacetylase, putative	0.0057	0.5816	0.3952
Brugia malayi	Histone deacetylase 1	0.0074	1	1
Echinococcus multilocularis	histone deacetylase 6	0.0063	0.7306	0.6105
Onchocerca volvulus		0.0046	0.3082	0.5
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3082	0.3082
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3082	0.3082
Mycobacterium ulcerans	ketoacyl reductase	0.0046	0.3082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Onchocerca volvulus		0.0046	0.3082	0.5
Loa Loa (eye worm)	histone deacetylase 1	0.0074	1	1
Leishmania major	histone deacetylase, putative	0.0074	1	1
Onchocerca volvulus		0.0046	0.3082	0.5
Loa Loa (eye worm)	oxidoreductase	0.0046	0.3082	0.3082
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3082	0.3082
Schistosoma mansoni	histone deacetylase	0.0074	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Trypanosoma brucei	histone deacetylase, putative	0.0057	0.5816	0.3952
Loa Loa (eye worm)	oxidoreductase	0.0046	0.3082	0.3082
Echinococcus multilocularis	histone deacetylase	0.0057	0.5816	0.3952
Onchocerca volvulus		0.0046	0.3082	0.5
Onchocerca volvulus		0.0046	0.3082	0.5
Loa Loa (eye worm)	oxidoreductase	0.0046	0.3082	0.3082
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0046	0.3082	0.3082
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0046	0.3082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0046	0.3082	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0046	0.3082	0.5
Mycobacterium tuberculosis	Possible oxidoreductase	0.0046	0.3082	0.5
Onchocerca volvulus		0.0046	0.3082	0.5
Schistosoma mansoni	histone deacetylase	0.0074	1	1
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.0046	0.3082	0.5
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0046	0.3082	0.5
Loa Loa (eye worm)	oxidoreductase	0.0046	0.3082	0.3082
Echinococcus multilocularis	histone deacetylase 7	0.0057	0.5816	0.3952
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.0046	0.3082	0.5
Toxoplasma gondii	histone deacetylase HDAC3	0.0074	1	1
Loa Loa (eye worm)	histone deacetylase 3	0.0074	1	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3082	0.3082
Mycobacterium tuberculosis	Decaprenylphosphoryl-D-2-keto erythro pentose reductase	0.0046	0.3082	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0046	0.3082	0.5
Mycobacterium ulcerans	dehydrogenase/decarboxylase protein	0.0046	0.3082	0.5
Schistosoma mansoni	histone deacetylase 4 5	0.0057	0.5816	0.3952
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0046	0.3082	0.5
Trypanosoma brucei	histone deacetylase 4	0.0057	0.5816	0.3952
Plasmodium vivax	histone deacetylase 1, putative	0.0074	1	1
Mycobacterium ulcerans	ketoacyl reductase	0.0046	0.3082	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0046	0.3082	0.5
Plasmodium falciparum	histone deacetylase 1	0.0074	1	1
Mycobacterium ulcerans	carveol-like dehydrogenase	0.0046	0.3082	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0046	0.3082	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0046	0.3082	0.5
Mycobacterium tuberculosis	Probable shortchain dehydrogenase	0.0046	0.3082	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0046	0.3082	0.5
Trichomonas vaginalis	histone deacetylase, putative	0.0074	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Onchocerca volvulus		0.0046	0.3082	0.5
Onchocerca volvulus		0.0046	0.3082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3082	0.3082
Leishmania major	histone deacetylase, putative	0.0074	1	1
Echinococcus granulosus	histone deacetylase 6	0.0063	0.7306	0.6105
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3082	0.3082
Leishmania major	histone deacetylase, putative	0.0057	0.5816	0.3952
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Loa Loa (eye worm)	dehydrogenase	0.0046	0.3082	0.3082
Mycobacterium ulcerans	short-chain dehydrogenase	0.0046	0.3082	0.5
Echinococcus granulosus	histone deacetylase 1	0.0074	1	1
Onchocerca volvulus		0.0046	0.3082	0.5
Mycobacterium tuberculosis	Probable short-chain type oxidoreductase	0.0046	0.3082	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0046	0.3082	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0046	0.3082	0.5
Loa Loa (eye worm)	dehydrogenase	0.0046	0.3082	0.3082
Brugia malayi	histone deacetylase 1 (HD1)	0.0074	1	1
Echinococcus granulosus	histone deacetylase	0.0057	0.5816	0.3952
Mycobacterium ulcerans	short-chain dehydrogenase	0.0046	0.3082	0.5
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3082	0.3082
Plasmodium vivax	histone deacetylase 2, putative	0.0057	0.5816	0.3952
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Plasmodium falciparum	histone deacetylase, putative	0.0057	0.5816	0.3952
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Trichomonas vaginalis	histone deacetylase, putative	0.0074	1	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0046	0.3082	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0046	0.3082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Toxoplasma gondii	histone deacetylase HDAC1	0.0057	0.5816	0.3952
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0046	0.3082	0.5
Mycobacterium tuberculosis	Probable dehydrogenase	0.0046	0.3082	0.5
Echinococcus multilocularis	histone deacetylase 1	0.0074	1	1
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0046	0.3082	0.5
Loa Loa (eye worm)	oxidoreductase	0.0046	0.3082	0.3082
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Brugia malayi	Histone deacetylase family protein	0.0057	0.5816	0.3952
Mycobacterium tuberculosis	Probable oxidoreductase	0.0046	0.3082	0.5
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3082	0.3082
Echinococcus granulosus	histone deacetylase 6	0.0057	0.5816	0.3952
Mycobacterium tuberculosis	Probable oxidoreductase	0.0046	0.3082	0.5
Mycobacterium tuberculosis	Probable short chain alcohol dehydrogenase/reductase	0.0046	0.3082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Trichomonas vaginalis	histone deacetylase, putative	0.0074	1	1
Schistosoma mansoni	histone deacetylase hda2	0.0063	0.7306	0.6105
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0046	0.3082	0.5
Mycobacterium tuberculosis	Possible fatty acyl-CoA reductase	0.0046	0.3082	0.5
Giardia lamblia	Histone deacetylase	0.0074	1	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3082	0.3082
Loa Loa (eye worm)	histone deacetylase 7A	0.0057	0.5816	0.5816
Onchocerca volvulus		0.0046	0.3082	0.5
Loa Loa (eye worm)	oxidoreductase	0.0046	0.3082	0.3082
Echinococcus granulosus	histone deacetylase 7	0.0057	0.5816	0.3952
Onchocerca volvulus		0.0046	0.3082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.0046	0.3082	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0046	0.3082	0.5
Plasmodium vivax	histone deacetylase, putative	0.0057	0.5816	0.3952
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3082	0.3082
Entamoeba histolytica	histone deacetylase, putative	0.0074	1	1
Leishmania major	histone deacetylase, putative	0.0057	0.5816	0.3952
Mycobacterium tuberculosis	Possible ketoacyl reductase	0.0046	0.3082	0.5
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0074	1	1
Trypanosoma cruzi	histone deacetylase 1, putative	0.0074	1	1
Trichomonas vaginalis	histone deacetylase, putative	0.0074	1	1
Mycobacterium tuberculosis	Possible oxidoreductase	0.0046	0.3082	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0046	0.3082	0.5
Mycobacterium ulcerans	short-chain type oxidoreductase	0.0046	0.3082	0.5
Mycobacterium leprae	Probable oxidoreductase	0.0046	0.3082	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0046	0.3082	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0046	0.3082	0.5
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0074	1	1
Trichomonas vaginalis	histone deacetylase, putative	0.0074	1	1
Brugia malayi	Histone deacetylase family protein	0.0057	0.5816	0.3952
Mycobacterium ulcerans	short chain dehydrogenase	0.0046	0.3082	0.5
Mycobacterium ulcerans	oxidoreductase	0.0046	0.3082	0.5
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3082	0.3082
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0046	0.3082	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2286530

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1808805