Detailed information for compound 1810154

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 327.417 | Formula: C20H25NO3
  • H donors: 2 H acceptors: 2 LogP: 3.45 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCNC[C@H](COc1ccc(cc1C(=O)c1ccccc1)C)O
  • InChi: 1S/C20H25NO3/c1-3-11-21-13-17(22)14-24-19-10-9-15(2)12-18(19)20(23)16-7-5-4-6-8-16/h4-10,12,17,21-22H,3,11,13-14H2,1-2H3/t17-/m1/s1
  • InChiKey: MCVQRUTWBOKICU-QGZVFWFLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0032 1 1
Onchocerca volvulus 0.0032 1 1
Mycobacterium ulcerans oxidoreductase 0.0032 1 1
Trichomonas vaginalis ABC transporter, putative 0.0013 0.314 0.314
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.314 0.314
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0032 1 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0032 1 1
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0032 1 1
Onchocerca volvulus 0.0032 1 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0009 0.176 0.176
Trichomonas vaginalis ABC transporter, putative 0.0013 0.314 0.314
Giardia lamblia Hypothetical protein 0.0032 1 1
Schistosoma mansoni steroid dehydrogenase 0.0032 1 1
Onchocerca volvulus 0.0032 1 1
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0032 1 1
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0032 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0032 1 1
Plasmodium falciparum multidrug resistance protein 1 0.0013 0.314 0.314
Loa Loa (eye worm) oxidoreductase 0.0032 1 1
Entamoeba histolytica hypothetical protein 0.0032 1 1
Onchocerca volvulus 0.0032 1 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0032 1 1
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0032 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0032 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.314 0.314
Echinococcus multilocularis multidrug resistance protein 1 0.0009 0.176 0.176
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0032 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0032 1 1
Schistosoma mansoni steroid dehydrogenase 0.0032 1 1
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0032 1 1
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0032 1 1
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0032 1 1
Trypanosoma brucei oxidoreductase-like protein 0.0032 1 1
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0032 1 1
Toxoplasma gondii oxidoreductase, putative 0.0032 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0032 1 1
Onchocerca volvulus 0.0032 1 1
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0032 1 1
Echinococcus granulosus carbonyl reductase 1 0.0032 1 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0032 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.314 0.314
Trypanosoma cruzi hypothetical protein, conserved 0.0032 1 1
Leishmania major hypothetical protein, conserved 0.0032 1 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0032 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0032 1 1
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0032 1 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0032 1 1
Loa Loa (eye worm) oxidoreductase 0.0032 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0032 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0032 1 1
Schistosoma mansoni short chain dehydrogenase 0.0032 1 1
Echinococcus multilocularis carbonyl reductase 1 0.0032 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.314 0.314
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Plasmodium vivax multidrug resistance protein 1, putative 0.0013 0.314 0.314
Echinococcus multilocularis retinol dehydrogenase 11 0.0032 1 1
Leishmania major hypothetical protein, conserved 0.0032 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0032 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 1 1
Entamoeba histolytica hypothetical protein, conserved 0.0032 1 1
Brugia malayi hypothetical protein 0.0032 1 1
Echinococcus granulosus carbonyl reductase 1 0.0032 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0032 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0032 1 1
Trichomonas vaginalis abcb9, putative 0.0013 0.314 0.314
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0032 1 1
Mycobacterium ulcerans short-chain type oxidoreductase 0.0032 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0032 1 1
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0032 1 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0013 0.309 0.309
Plasmodium falciparum steroid dehydrogenase, putative 0.0032 1 1
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0032 1 1
Schistosoma mansoni short chain dehydrogenase 0.0032 1 1
Schistosoma mansoni steroid dehydrogenase 0.0032 1 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.314 0.314
Trichomonas vaginalis taga, putative 0.0013 0.314 0.314
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0032 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0032 1 1
Schistosoma mansoni steroid dehydrogenase 0.0032 1 1
Echinococcus multilocularis carbonyl reductase 1 0.0032 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Leishmania major p-glycoprotein 0.0013 0.314 0.314
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0032 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.314 0.314
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0032 1 1
Echinococcus multilocularis steroid dehydrogenase 0.0032 1 1
Loa Loa (eye worm) dehydrogenase 0.0032 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.314 0.314
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.314 0.314
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0032 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0032 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.314 0.314
Loa Loa (eye worm) hypothetical protein 0.0032 1 1
Onchocerca volvulus 0.0032 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0032 1 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0032 1 1
Onchocerca volvulus 0.0032 1 1
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0032 1 1
Leishmania major oxidoreductase-like protein 0.0032 1 1
Schistosoma mansoni carbonyl reductase 0.0032 1 1
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0032 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.314 0.314
Mycobacterium ulcerans carveol-like dehydrogenase 0.0032 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.314 0.314
Schistosoma mansoni steroid dehydrogenase 0.0032 1 1
Leishmania major hypothetical protein, conserved 0.0032 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Schistosoma mansoni steroid dehydrogenase 0.0032 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0032 1 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0032 1 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0032 1 1
Brugia malayi Dehydrogenases, short chain protein 30 0.0032 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.314 0.314
Loa Loa (eye worm) hypothetical protein 0.0013 0.314 0.314
Brugia malayi dehydrogenases, short chain protein 2 0.0032 1 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.314 0.314
Toxoplasma gondii oxidoreductase, putative 0.0032 1 1
Echinococcus granulosus WW domain containing oxidoreductase 0.0032 1 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0032 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.309 0.309
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0032 1 1
Entamoeba histolytica P-glycoprotein-2 0.0013 0.314 0.314
Loa Loa (eye worm) hypothetical protein 0.0032 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0032 1 1
Echinococcus multilocularis retinol dehydrogenase 13 0.0032 1 1
Plasmodium vivax steroid dehydrogenase, putative 0.0032 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0032 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0032 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0032 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0032 1 1
Trichomonas vaginalis steroid dehydrogenase, putative 0.0032 1 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.314 0.314
Schistosoma mansoni multidrug resistance protein 0.0013 0.314 0.314
Schistosoma mansoni multidrug resistance protein 0.0013 0.314 0.314
Onchocerca volvulus Sepiapterin reductase homolog 0.0032 1 1
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0032 1 1
Schistosoma mansoni steroid dehydrogenase 0.0032 1 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.309 0.309
Schistosoma mansoni carbonyl reductase 0.0032 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0032 1 1
Echinococcus granulosus steroid dehydrogenase 0.0032 1 1
Onchocerca volvulus 0.0032 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Echinococcus multilocularis carbonyl reductase 1 0.0032 1 1
Loa Loa (eye worm) oxidoreductase 0.0032 1 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0032 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0032 1 1
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0032 1 1
Loa Loa (eye worm) oxidoreductase 0.0032 1 1
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0032 1 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0013 0.314 0.314
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0032 1 1
Schistosoma mansoni short chain dehydrogenase 0.0032 1 1
Leishmania major 3-keto-dihydrosphingosine reductase 0.0032 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0032 1 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0032 1 1
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.314 0.314
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Schistosoma mansoni short chain dehydrogenase 0.0032 1 1
Echinococcus granulosus retinol dehydrogenase 11 0.0032 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.314 0.314
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Leishmania major short chain dehydrogenase/reductase, putative 0.0032 1 1
Leishmania major hypothetical protein, conserved 0.0032 1 1
Schistosoma mansoni steroid dehydrogenase 0.0032 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0032 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.314 0.314
Mycobacterium tuberculosis Probable oxidoreductase 0.0032 1 1
Mycobacterium ulcerans ketoacyl reductase 0.0032 1 1
Schistosoma mansoni smdr2 0.0013 0.314 0.314
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0032 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.314 0.314
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0032 1 1
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0032 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.314 0.314
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.314 0.314
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0032 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0032 1 1
Toxoplasma gondii carbonyl reductase 1, putative 0.0032 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0032 1 1
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0032 1 1
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0032 1 1
Brugia malayi ABC transporter family protein 0.0013 0.314 0.314
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0032 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.314 0.314
Schistosoma mansoni short chain dehydrogenase 0.0032 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0032 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0032 1 1
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0032 1 1
Schistosoma mansoni short chain dehydrogenase 0.0032 1 1
Leishmania major pteridine reductase 1 0.0032 1 1
Schistosoma mansoni short chain dehydrogenase 0.0032 1 1
Mycobacterium ulcerans ketoacyl reductase 0.0032 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.314 0.314
Onchocerca volvulus 0.0032 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0032 1 1
Mycobacterium leprae Probable oxidoreductase 0.0032 1 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0032 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0032 1 1
Mycobacterium ulcerans oxidoreductase 0.0032 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0032 1 1
Mycobacterium ulcerans ketoacyl reductase 0.0032 1 1
Schistosoma mansoni short chain dehydrogenase 0.0032 1 1
Entamoeba histolytica P-glycoprotein-2 0.0013 0.314 0.314
Schistosoma mansoni short chain dehydrogenase 0.0032 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0032 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 1 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0032 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0032 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0032 1 1
Leishmania major dehydrogenase-like protein 0.0032 1 1
Echinococcus granulosus hypothetical protein 0.0032 1 1
Brugia malayi Dehydrogenases, short chain protein 2 0.0032 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 1 1
Echinococcus multilocularis steroid dehydrogenase 0.0032 1 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0032 1 1
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0032 1 1
Schistosoma mansoni short chain dehydrogenase 0.0032 1 1
Brugia malayi dehydrogenases, short chain protein 9 0.0032 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.314 0.314
Trypanosoma brucei short-chain dehydrogenase, putative 0.0032 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0032 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.314 0.314
Schistosoma mansoni short chain dehydrogenase 0.0032 1 1
Brugia malayi oxidoreductase 0.0032 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0032 1 1
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0013 0.314 0.5
Echinococcus granulosus multidrug resistance protein 1 0.0009 0.176 0.176
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.314 0.314
Entamoeba histolytica hypothetical protein, conserved 0.0032 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0032 1 1
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0032 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.314 0.314
Onchocerca volvulus 0.0032 1 1
Schistosoma mansoni carbonyl reductase 0.0032 1 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0032 1 1
Leishmania major hypothetical protein, conserved 0.0032 1 1
Schistosoma mansoni short chain dehydrogenase 0.0032 1 1
Onchocerca volvulus 0.0032 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Onchocerca volvulus 0.0032 1 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0032 1 1
Brugia malayi Retinol dehydrogenase 12 0.0032 1 1
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0013 0.314 0.314
Schistosoma mansoni short chain dehydrogenase 0.0032 1 1
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0032 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.314 0.314
Loa Loa (eye worm) oxidoreductase 0.0032 1 1
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0032 1 1
Trichomonas vaginalis ABC transporter, putative 0.0013 0.314 0.314
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.314 0.314
Loa Loa (eye worm) oxidoreductase 0.0032 1 1
Loa Loa (eye worm) dehydrogenase 0.0032 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0032 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0032 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0032 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.314 0.314
Leishmania major short chain dehydrogenase/reductase, putative 0.0032 1 1
Entamoeba histolytica P-glycoprotein-1 0.0013 0.314 0.314
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0032 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Entamoeba histolytica P-glycoprotein-5 0.0013 0.314 0.314
Loa Loa (eye worm) oxidoreductase 0.0032 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0032 1 1
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0032 1 1
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0032 1 1
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.314 0.314
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Echinococcus granulosus carbonyl reductase 1 0.0032 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0032 1 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0013 0.314 0.314
Echinococcus multilocularis retinol dehydrogenase 11 0.0032 1 1
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0032 1 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0032 1 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0032 1 1
Schistosoma mansoni steroid dehydrogenase 0.0032 1 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0013 0.314 0.314
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0032 1 1
Mycobacterium ulcerans dehydrogenase 0.0032 1 1
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0032 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0032 1 1
Echinococcus multilocularis carbonyl reductase 1 0.0032 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0032 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 1 1
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0013 0.314 0.314
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0032 1 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.314 0.314
Leishmania major short chain dehydrogenase-like protein 0.0032 1 1
Leishmania major short chain dehydrogenase, putative 0.0032 1 1
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0032 1 1
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0032 1 1
Trichomonas vaginalis abcb9, putative 0.0013 0.314 0.314
Entamoeba histolytica P-glyco protein 6, putative 0.0013 0.314 0.314
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0032 1 1
Trichomonas vaginalis abcb9, putative 0.0013 0.314 0.314
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.314 0.314
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0032 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0032 1 1
Schistosoma mansoni short chain dehydrogenase 0.0032 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0032 1 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0032 1 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0013 0.314 0.314
Schistosoma mansoni short chain dehydrogenase 0.0032 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0032 1 1
Loa Loa (eye worm) oxidoreductase 0.0032 1 1
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0032 1 1
Onchocerca volvulus 0.0032 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.314 0.314
Echinococcus granulosus hypothetical protein 0.0032 1 1
Schistosoma mansoni multidrug resistance protein 0.0013 0.314 0.314
Trypanosoma cruzi hypothetical protein, conserved 0.0032 1 1
Trichomonas vaginalis ABC transporter, putative 0.0013 0.314 0.314
Leishmania major short chain dehydrogenase, putative 0.0032 1 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.0032 1 1
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0032 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0032 1 1
Mycobacterium ulcerans dehydrogenase/reductase 0.0032 1 1
Entamoeba histolytica short chain dehydrogenase family protein 0.0032 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0032 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0032 1 1
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0032 1 1
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0032 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0009 0.176 0.176
Echinococcus granulosus carbonyl reductase 1 0.0032 1 1
Plasmodium vivax hypothetical protein, conserved 0.0032 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.0032 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Schistosoma mansoni retinal dehydrogenase 0.0032 1 1
Schistosoma mansoni steroid dehydrogenase 0.0032 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0032 1 1
Loa Loa (eye worm) oxidoreductase 0.0032 1 1
Giardia lamblia Reductase, putative 0.0032 1 1
Entamoeba histolytica P-glycoprotein-2, putative 0.0013 0.314 0.314
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.314 0.314
Giardia lamblia Short-chain dehydrogenase, putative 0.0032 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.314 0.314
Leishmania major quinonoid dihydropteridine reductase 0.0032 1 1
Echinococcus granulosus oxidoreductase 0.0032 1 1
Entamoeba histolytica short chain dehydrogenase family protein 0.0032 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.314 0.314
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0032 1 1
Entamoeba histolytica P-glycoprotein 5, putative 0.0013 0.314 0.314
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0032 1 1
Brugia malayi multidrug resistance protein 3 0.0013 0.314 0.314
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0032 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0032 1 1
Echinococcus multilocularis conserved hypothetical protein 0.0032 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0032 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0032 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.314 0.314
Brugia malayi hypothetical protein 0.0032 1 1
Echinococcus multilocularis oxidoreductase 0.0032 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0032 1 1
Echinococcus granulosus retinol dehydrogenase 11 0.0032 1 1
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0032 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 1 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 5.92 SUPPLEMENTARY: Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay. Same assay as CHEMBL914418 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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