Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Zea mays | Glutamine synthetase, chloroplastic | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | glutamine synthetase, type I, putative | Glutamine synthetase, chloroplastic | 423 aa | 342 aa | 22.8 % |
Neospora caninum | Glutamine synthetase (EC 6.3.1.2), related | Glutamine synthetase, chloroplastic | 423 aa | 346 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | glutamine synthetase, putative | 0.0138 | 0.7067 | 0.5 |
Mycobacterium ulcerans | glutamine synthetase GlnA1 | 0.0089 | 0.3146 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.6406 | 1 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) | 0.0089 | 0.3146 | 0.5 |
Onchocerca volvulus | 0.013 | 0.6406 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.52 | 0.63 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.5158 | 0.6173 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0138 | 0.7067 | 0.5 |
Toxoplasma gondii | glutamine synthetase, type I, putative | 0.0089 | 0.3146 | 0.5 |
Mycobacterium ulcerans | glutamine synthetase | 0.0089 | 0.3146 | 0.5 |
Mycobacterium leprae | PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) | 0.0089 | 0.3146 | 0.5 |
Echinococcus multilocularis | glutamine synthetase | 0.0138 | 0.7067 | 1 |
Plasmodium vivax | glutamine synthetase, putative | 0.0089 | 0.3146 | 0.5 |
Plasmodium falciparum | glutamine synthetase, putative | 0.0089 | 0.3146 | 0.5 |
Echinococcus granulosus | glutamine synthetase | 0.0138 | 0.7067 | 1 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0138 | 0.7067 | 0.5 |
Brugia malayi | PAS domain containing protein | 0.006 | 0.088 | 0.1705 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0114 | 0.5158 | 1 |
Leishmania major | glutamine synthetase, putative | 0.0138 | 0.7067 | 0.5 |
Schistosoma mansoni | glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) | 0.0138 | 0.7067 | 0.6784 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | Growth inhibition of Arabidopsis thaliana suspension cultured cells assessed as reduction in dry weight increase measured 8 days after compound incubation | ChEMBL. | 18399639 | |
IC50 (binding) | = 3.951 | Inhibition of Arabidopsis thaliana P5C assessed as reduction in NADH oxidation incubated at 35 degC up to 10 min | ChEMBL. | 18399639 |
IC50 (binding) | = 4.824 | Inhibition of Zea mays cv. Jeff (maize) leaf glutamine synthetase using L-glutamate as substrate assessed as inorganic phosphate production after 20 min by malachite green assay relative to control | ChEMBL. | 19697446 |
IC50 (binding) | = 0.112 mM | Inhibition of Arabidopsis thaliana P5C assessed as reduction in NADH oxidation incubated at 35 degC up to 10 min | ChEMBL. | 18399639 |
IC50 (binding) | = 15 uM | Inhibition of Zea mays cv. Jeff (maize) leaf glutamine synthetase using L-glutamate as substrate assessed as inorganic phosphate production after 20 min by malachite green assay relative to control | ChEMBL. | 19697446 |
Inhibition (binding) | = 81.1 % | Inhibition of Zea mays cv. Jeff (maize) leaf glutamine synthetase using L-glutamate as substrate assessed as inorganic phosphate production at 1 mM after 20 min by malachite green assay relative to control | ChEMBL. | 19697446 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.