Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Arabidopsis thaliana | acetolactate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hexose transporter, putative | 0.0063 | 0.1247 | 1 |
Trypanosoma brucei | glucose transporter 1E | 0.0063 | 0.1247 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0203 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0203 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0203 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0203 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0203 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0133 | 0.5628 | 1 |
Trypanosoma brucei | glucose transporter 2A | 0.0063 | 0.1247 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0203 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0203 | 1 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0203 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0063 | 0.1247 | 1 |
Mycobacterium ulcerans | acetolactate synthase | 0.0076 | 0.2071 | 0.368 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0133 | 0.5628 | 0.5 |
Plasmodium vivax | hexose transporter | 0.0203 | 1 | 1 |
Plasmodium falciparum | hexose transporter | 0.0203 | 1 | 1 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0133 | 0.5628 | 1 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0063 | 0.1247 | 1 |
Leishmania major | glucose transporter, lmgt3 | 0.0063 | 0.1247 | 0.6022 |
Trypanosoma cruzi | hexose transporter, putative | 0.0063 | 0.1247 | 1 |
Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0063 | 0.1247 | 0.6022 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0133 | 0.5628 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0133 | 0.5628 | 1 |
Loa Loa (eye worm) | sugar transporter | 0.0203 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0063 | 0.1247 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0203 | 1 | 1 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0063 | 0.1247 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0203 | 1 | 1 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0076 | 0.2071 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0063 | 0.1247 | 1 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0203 | 1 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0203 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0063 | 0.1247 | 1 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0063 | 0.1247 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0063 | 0.1247 | 1 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0133 | 0.5628 | 1 |
Trypanosoma cruzi | hexose transporter, putative | 0.0063 | 0.1247 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0063 | 0.1247 | 1 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0133 | 0.5628 | 1 |
Leishmania major | glucose transporter, lmgt1 | 0.0063 | 0.1247 | 0.6022 |
Trypanosoma brucei | glucose transporter, putative | 0.0063 | 0.1247 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0063 | 0.1247 | 1 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0076 | 0.2071 | 0.368 |
Leishmania major | glucose transporter, lmgt2 | 0.0063 | 0.1247 | 0.6022 |
Loa Loa (eye worm) | ILVBL protein | 0.008 | 0.2348 | 0.0339 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0076 | 0.2071 | 0.368 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0203 | 1 | 1 |
Trypanosoma cruzi | hexose transporter | 0.0063 | 0.1247 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0203 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 18.5 uM | Inhibition of wild type Arabidopsis thaliana acetolactate synthase by colorimetry | ChEMBL. | 20598554 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.