Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Entamoeba histolytica | cysteine protease, putative | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hyaluronidase | 0.0856 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0063 | 0.0534 | 0.8824 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.0606 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.1965 | 0.1965 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0606 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0745 | 0.8666 | 0.8666 |
Toxoplasma gondii | cathepsin CPL | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0183 | 0.1965 | 0.1965 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0018 | 0 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0606 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.0606 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0606 | 0.5 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0069 | 0.0606 | 1 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0606 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.1965 | 0.1965 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.0606 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0364 | 0.4124 | 0.4124 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.0856 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0856 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0606 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0745 | 0.8666 | 0.8666 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0054 | 0.043 | 0.7098 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0745 | 0.8666 | 0.8666 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0606 | 0.5 |
Schistosoma mansoni | Hyaluronidase | 0.0856 | 1 | 1 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0606 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0018 | 0 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.0606 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0018 | 0 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0606 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.0606 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Echinococcus multilocularis | geminin | 0.0183 | 0.1965 | 0.1965 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0606 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0018 | 0 | 0.5 |
Onchocerca volvulus | Cathepsin L homolog | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.0606 | 1 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.0856 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0018 | 0 | 0.5 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0606 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.0606 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (ADMET) | = 25.6 % | Cytotoxicity against HEK293T cells at 50 ug/ml after 72 hrs by MTT assay | ChEMBL. | 24314670 |
MIC (functional) | = 6.25 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as parasite growth inhibition after 28 days by agar dilution method | ChEMBL. | 24314670 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.