Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Adenylate cyclase type I | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0034 | 0.1107 | 0.2563 |
Onchocerca volvulus | 0.0135 | 0.9504 | 0.9442 | |
Echinococcus multilocularis | eukaryotic translation initiation factor 4E | 0.0072 | 0.4256 | 0.4256 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1107 | 0.0467 |
Loa Loa (eye worm) | translation initiation factor 4E | 0.0072 | 0.4256 | 0.3843 |
Onchocerca volvulus | Adenylate cyclase type 3 homolog | 0.0141 | 1 | 1 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0072 | 0.4256 | 0.5 |
Leishmania major | eukaryotic translation initiation factor eIF-4E, putative | 0.0072 | 0.4256 | 1 |
Echinococcus granulosus | ectonucleotide | 0.0028 | 0.0671 | 0.0671 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0072 | 0.4256 | 0.5 |
Echinococcus multilocularis | adenylate cyclase 9 | 0.0141 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1107 | 0.1107 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0034 | 0.1107 | 0.2563 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0072 | 0.4319 | 0.4319 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.4319 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0034 | 0.1107 | 0.2563 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1107 | 0.1107 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0072 | 0.4319 | 0.391 |
Leishmania major | eukaryotic translation initiation factor-like protein | 0.0072 | 0.4256 | 1 |
Echinococcus multilocularis | ectonucleotide | 0.0028 | 0.0671 | 0.0671 |
Schistosoma mansoni | eukaryotic translation initiation factor 4e | 0.0072 | 0.4256 | 0.9855 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0072 | 0.4256 | 0.5 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0072 | 0.4256 | 0.5 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0072 | 0.4256 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1107 | 0.0467 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0072 | 0.4256 | 1 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0034 | 0.1107 | 0.1107 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1107 | 0.1107 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1107 | 0.1107 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.9504 | 0.9468 |
Brugia malayi | translation initiation factor 4E | 0.0072 | 0.4256 | 0.4256 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0028 | 0.0671 | 0.0671 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1107 | 0.1107 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1107 | 0.1107 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0072 | 0.4256 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1107 | 0.1107 |
Onchocerca volvulus | 0.0072 | 0.4319 | 0.3611 | |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1107 | 0.1107 |
Loa Loa (eye worm) | adenylyl cyclase 3 | 0.0141 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0028 | 0.0671 | 0.0671 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.0072 | 0.4256 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1107 | 0.1107 |
Onchocerca volvulus | 0.0141 | 1 | 1 | |
Echinococcus granulosus | adenylate cyclase 9 | 0.0141 | 1 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0034 | 0.1107 | 0.2563 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1107 | 0.1107 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 1 | 1 |
Leishmania major | eukaryotic translation initiation factor-like | 0.0072 | 0.4256 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1107 | 0.1107 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-1 | 0.0072 | 0.4256 | 1 |
Onchocerca volvulus | Adenylate cyclase type 2 homolog | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1107 | 0.0467 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E | 0.0072 | 0.4256 | 0.4256 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0072 | 0.4256 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 94 nM | Displacement of [125I]-6-IHPP-Fsk from adenylate cyclase of bovine brain membrane | ChEMBL. | 1956039 |
Kd (binding) | = 94 nM | Displacement of [125I]-6-IHPP-Fsk from adenylate cyclase of bovine brain membrane | ChEMBL. | 1956039 |
Kd (binding) | > 100 uM | Inhibition of [125I]-7-IHPP-Fsk binding to glucose transporter of human erythrocyte membrane | ChEMBL. | 1956039 |
Kd (binding) | > 100 uM | Inhibition of [125I]-7-IHPP-Fsk binding to glucose transporter of human erythrocyte membrane | ChEMBL. | 1956039 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.