Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | stearoyl-Coenzyme A desaturase 1 | Starlite/ChEMBL | References |
Homo sapiens | stearoyl-CoA desaturase (delta-9-desaturase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0312 | 0.5397 | 1 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0312 | 0.5397 | 1 |
Brugia malayi | Lethal protein 805 | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Onchocerca volvulus | 0.0312 | 0.5397 | 1 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Onchocerca volvulus | 0.0312 | 0.5397 | 1 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0312 | 0.5397 | 1 |
Brugia malayi | protein unc-22 | 0.0312 | 0.5397 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0223 | 0.0904 | 0.1674 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0312 | 0.5397 | 1 |
Onchocerca volvulus | 0.0312 | 0.5397 | 1 | |
Onchocerca volvulus | 0.0312 | 0.5397 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0312 | 0.5397 | 1 |
Trypanosoma cruzi | Fibronectin type III domain containing protein, putative | 0.0312 | 0.5397 | 1 |
Brugia malayi | hypothetical protein | 0.0312 | 0.5397 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0312 | 0.5397 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0312 | 0.5397 | 1 |
Trypanosoma cruzi | Fibronectin type III domain containing protein, putative | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0312 | 0.5397 | 1 |
Brugia malayi | protein-tyrosine phosphatase Lar-like precursor, putative | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | projectin | 0.0312 | 0.5397 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0312 | 0.5397 | 1 |
Trypanosoma brucei | Fibronectin type III domain containing protein, putative | 0.0312 | 0.5397 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0205 | 0 | 0.5 |
Onchocerca volvulus | 0.0312 | 0.5397 | 1 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0312 | 0.5397 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0312 | 0.5397 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0404 | 1 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0312 | 0.5397 | 1 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 30. | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | CAMK protein kinase | 0.0312 | 0.5397 | 1 |
Onchocerca volvulus | 0.0312 | 0.5397 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0312 | 0.5397 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0205 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | UNCoordinated family member | 0.0312 | 0.5397 | 1 |
Brugia malayi | myotactin form A | 0.0312 | 0.5397 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0312 | 0.5397 | 1 |
Onchocerca volvulus | 0.0312 | 0.5397 | 1 | |
Brugia malayi | SPRY domain containing protein | 0.0312 | 0.5397 | 1 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 32 | 0.0312 | 0.5397 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0312 | 0.5397 | 1 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Onchocerca volvulus | 0.0312 | 0.5397 | 1 | |
Leishmania major | hypothetical protein, conserved | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0312 | 0.5397 | 1 |
Onchocerca volvulus | 0.0312 | 0.5397 | 1 | |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | myotactin form A | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.5397 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0312 | 0.5397 | 1 |
Onchocerca volvulus | 0.0312 | 0.5397 | 1 | |
Onchocerca volvulus | 0.0312 | 0.5397 | 1 | |
Brugia malayi | Lethal protein 805 | 0.0312 | 0.5397 | 1 |
Loa Loa (eye worm) | lethal protein 805 | 0.0312 | 0.5397 | 1 |
Onchocerca volvulus | 0.0312 | 0.5397 | 1 | |
Brugia malayi | hypothetical protein | 0.0312 | 0.5397 | 1 |
Brugia malayi | myotactin form B | 0.0312 | 0.5397 | 1 |
Schistosoma mansoni | ephrin receptor | 0.0404 | 1 | 1 |
Onchocerca volvulus | 0.0312 | 0.5397 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 15 nM | Inhibition of SCD1 in mouse liver microsomes | ChEMBL. | 24374272 |
IC50 (binding) | = 55 nM | Inhibition of SCD1 in human HepG2 cells using [1-14C]stearic acid as substrate | ChEMBL. | 24374272 |
Inhibition (binding) | Inhibition of human delta-5 desaturase at 10 uM | ChEMBL. | 24374272 | |
Inhibition (binding) | Inhibition of human delta-6 desaturase at 10 uM | ChEMBL. | 24374272 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.