Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 500 aa | 429 aa | 24.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.007 | 0.0196 | 1 |
Onchocerca volvulus | 0.1572 | 1 | 1 | |
Giardia lamblia | Hypothetical protein | 0.0042 | 0.0008 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0901 | 0.562 | 0.562 |
Onchocerca volvulus | 0.0671 | 0.4116 | 0.3998 | |
Onchocerca volvulus | 0.0901 | 0.562 | 0.5532 | |
Loa Loa (eye worm) | hypothetical protein | 0.1572 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0671 | 0.4116 | 0.4116 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.007 | 0.0196 | 0.5 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.007 | 0.0196 | 0.5 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0042 | 0.0008 | 0.5 |
Onchocerca volvulus | 0.1572 | 1 | 1 | |
Onchocerca volvulus | 0.1572 | 1 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0901 | 0.562 | 0.2556 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.1572 | 1 | 1 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.1572 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0042 | 0.0008 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0042 | 0.0008 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0188 | 0.0188 |
Onchocerca volvulus | 0.1572 | 1 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0671 | 0.4116 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0901 | 0.562 | 0.562 |
Loa Loa (eye worm) | hypothetical protein | 0.0671 | 0.4116 | 0.4116 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0042 | 0.0008 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.007 | 0.0196 | 1 |
Onchocerca volvulus | 0.1572 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0671 | 0.4116 | 0.4116 |
Loa Loa (eye worm) | hypothetical protein | 0.0901 | 0.562 | 0.562 |
Onchocerca volvulus | 0.0901 | 0.562 | 0.5532 | |
Onchocerca volvulus | 0.1572 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0671 | 0.4116 | 0.4116 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.007 | 0.0196 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0901 | 0.562 | 0.562 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0901 | 0.562 | 0.562 |
Schistosoma mansoni | 6-phosphofructokinase | 0.007 | 0.0196 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.1572 | 1 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0901 | 0.562 | 0.2556 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0196 | 0.0196 |
Brugia malayi | hypothetical protein | 0.0901 | 0.562 | 0.2556 |
Onchocerca volvulus | 0.1572 | 1 | 1 | |
Brugia malayi | hypothetical protein | 0.0901 | 0.562 | 0.2556 |
Loa Loa (eye worm) | hypothetical protein | 0.0901 | 0.562 | 0.562 |
Onchocerca volvulus | 0.1572 | 1 | 1 | |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.007 | 0.0196 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0901 | 0.562 | 0.2556 |
Loa Loa (eye worm) | hypothetical protein | 0.0901 | 0.562 | 0.562 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.49 uM | Inhibition of human recombinant GST-tagged PFKFB3 expressed in Escherichia coli BL21(DE3) using fructose 6-phosphate as substrate preincubated for 30 mins before substrate addition measured after 60 mins by kinase-glo assay | ChEMBL. | 24398380 |
IC50 (binding) | = 27 uM | Inhibition of PFKFB3 (unknown origin) | ChEMBL. | 24398380 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.