Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0084 | 0.0084 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0367 | 0.5692 | 0.5692 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0044 | 0.0597 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0084 | 0.0084 |
Onchocerca volvulus | 0.064 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0084 | 0.0084 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0084 | 0.0352 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0084 | 0.0342 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.4213 | 0.4213 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.0084 | 0.0342 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.0084 | 0.0084 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.0084 | 0.0352 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0084 | 0.0084 |
Brugia malayi | hypothetical protein | 0.0367 | 0.5692 | 0.5692 |
Onchocerca volvulus | 0.0367 | 0.5692 | 0.5656 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0084 | 0.0084 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.064 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0084 | 0.0084 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0163 | 0.247 | 0.247 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0048 | 0.066 | 0.5 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0163 | 0.247 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.5692 | 0.5692 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0084 | 0.0342 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0084 | 0.0342 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0367 | 0.5692 | 0.5692 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0084 | 0.0084 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0084 | 0.0342 |
Brugia malayi | LBP/BPI | 0.0273 | 0.4213 | 0.4213 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0084 | 0.0342 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.5692 | 0.5692 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0273 | 0.4213 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0084 | 0.0084 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0084 | 0.0342 |
Onchocerca volvulus | 0.064 | 1 | 1 | |
Onchocerca volvulus | 0.064 | 1 | 1 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0084 | 0.0084 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0084 | 0.0342 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0044 | 0.0597 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0084 | 0.0084 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0084 | 0.0084 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0084 | 0.0352 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | acetyltransferase | 0.0163 | 0.247 | 0.247 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.4213 | 0.4213 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0158 | 0.2398 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0084 | 0.0084 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0084 | 0.0084 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0163 | 0.247 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.064 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.0084 | 0.0084 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.0084 | 0.0084 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0048 | 0.066 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0084 | 0.0084 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.0084 | 0.0342 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.5692 | 0.5692 |
Onchocerca volvulus | 0.064 | 1 | 1 | |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0084 | 0.0342 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0367 | 0.5692 | 0.5692 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0367 | 0.5692 | 0.5692 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0084 | 0.0342 |
Onchocerca volvulus | 0.064 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.5692 | 0.5692 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.064 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.0084 | 0.0352 |
Brugia malayi | hypothetical protein | 0.0273 | 0.4213 | 0.4213 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.0084 | 0.0352 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.5692 | 0.5692 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0084 | 0.0342 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.064 | 1 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0044 | 0.0597 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.0084 | 0.0342 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0084 | 0.0084 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.0084 | 0.0084 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0084 | 0.0342 |
Onchocerca volvulus | 0.064 | 1 | 1 | |
Onchocerca volvulus | 0.0273 | 0.4213 | 0.4164 | |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0084 | 0.0084 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0084 | 0.0084 |
Onchocerca volvulus | 0.064 | 1 | 1 | |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0084 | 0.0352 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0084 | 0.0342 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.0084 | 0.0352 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0084 | 0.0084 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0084 | 0.0084 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0084 | 0.0352 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0084 | 0.0342 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.0084 | 0.0342 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0367 | 0.5692 | 0.5692 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.0084 | 0.0084 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0048 | 0.066 | 0.5 |
Onchocerca volvulus | 0.0367 | 0.5692 | 0.5656 | |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0084 | 0.0352 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0084 | 0.0342 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0084 | 0.0342 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.4213 | 0.4213 |
Brugia malayi | hypothetical protein | 0.0367 | 0.5692 | 0.5692 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0084 | 0.0342 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0084 | 0.0342 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.4213 | 0.4213 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0048 | 0.066 | 0.2751 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0084 | 0.0342 |
Onchocerca volvulus | 0.064 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 50 ug ml-1 | Antifungal activity against Candida albicans ATCC 66027 by microbroth dilution method | ChEMBL. | 24513049 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.