TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 583.502 | Formula: C29H19F2N7O5
H donors: 1 H acceptors: 6 LogP: 4.79 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: COc1ccc(c(c1)F)n1cccc(c1=O)C(=O)Nc1ccc(c(c1)F)Oc1ncnc(c1)On1nnc2c1cccc2
InChi: 1S/C29H19F2N7O5/c1-41-18-9-10-23(20(30)14-18)37-12-4-5-19(29(37)40)28(39)34-17-8-11-25(21(31)13-17)42-26-15-27(33-16-32-26)43-38-24-7-3-2-6-22(24)35-36-38/h2-16H,1H3,(H,34,39)
InChiKey: JXRULXWFJIFOFZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0056	0.875	1
Echinococcus granulosus	carbonyl reductase 1	0.0056	0.875	1
Loa Loa (eye worm)	oxidoreductase	0.0056	0.875	0.875
Mycobacterium tuberculosis	Probable oxidoreductase	0.0056	0.875	1
Giardia lamblia	Short-chain dehydrogenase, putative	0.0056	0.875	1
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.0056	0.875	1
Leishmania major	short chain dehydrogenase-like protein	0.0056	0.875	1
Loa Loa (eye worm)	oxidoreductase	0.0056	0.875	0.875
Onchocerca volvulus		0.0056	0.875	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0056	0.875	1
Onchocerca volvulus		0.0056	0.875	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0056	0.875	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0056	0.875	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.0056	0.875	1
Mycobacterium ulcerans	short-chain type oxidoreductase	0.0056	0.875	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.875
Echinococcus granulosus	retinol dehydrogenase 11	0.0056	0.875	1
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.5
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0056	0.875	1
Onchocerca volvulus		0.0056	0.875	0.5
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.0056	0.875	1
Leishmania major	hypothetical protein, conserved	0.0056	0.875	1
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0056	0.875	1
Brugia malayi	dehydrogenases, short chain protein 9	0.0056	0.875	0.875
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.875	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.875	0.875
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0056	0.875	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0056	0.875	1
Onchocerca volvulus		0.0056	0.875	0.5
Toxoplasma gondii	oxidoreductase, putative	0.0056	0.875	0.5
Schistosoma mansoni	carbonyl reductase	0.0056	0.875	1
Schistosoma mansoni	steroid dehydrogenase	0.0056	0.875	1
Leishmania major	dehydrogenase-like protein	0.0056	0.875	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.875	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0056	0.875	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.875
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.0056	0.875	1
Onchocerca volvulus		0.0056	0.875	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Plasmodium vivax	steroid dehydrogenase, putative	0.0056	0.875	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0056	0.875	1
Mycobacterium ulcerans	short-chain dehydrogenase	0.0056	0.875	1
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.0056	0.875	1
Onchocerca volvulus		0.0056	0.875	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0056	0.875	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.875	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.875	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.875
Leishmania major	short chain dehydrogenase/reductase, putative	0.0056	0.875	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.875	1
Mycobacterium tuberculosis	Possible iron-regulated short-chain dehydrogenase/reductase	0.0056	0.875	1
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0056	0.875	1
Loa Loa (eye worm)	oxidoreductase	0.0056	0.875	0.875
Onchocerca volvulus	Sepiapterin reductase homolog	0.0056	0.875	0.5
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.4837	0.4837
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.875
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.0056	0.875	1
Brugia malayi	dehydrogenases, short chain protein 2	0.0056	0.875	0.875
Mycobacterium ulcerans	dehydrogenase	0.0056	0.875	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Onchocerca volvulus		0.0056	0.875	0.5
Entamoeba histolytica	oxidoreductase, short chain dehydrogenase/reductase family	0.0056	0.875	1
Echinococcus granulosus	carbonyl reductase 1	0.0056	0.875	1
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0056	0.875	1
Mycobacterium ulcerans	ketoacyl reductase	0.0056	0.875	1
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0056	0.875	1
Mycobacterium tuberculosis	Decaprenylphosphoryl-D-2-keto erythro pentose reductase	0.0056	0.875	1
Leishmania major	hypothetical protein, conserved	0.0056	0.875	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0056	0.875	1
Brugia malayi	hypothetical protein	0.0056	0.875	0.875
Echinococcus multilocularis	carbonyl reductase 1	0.0056	0.875	1
Echinococcus multilocularis	steroid dehydrogenase	0.0056	0.875	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.875	0.875
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Schistosoma mansoni	carbonyl reductase	0.0056	0.875	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.875
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0056	0.875	1
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.0056	0.875	1
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.0056	0.875	1
Mycobacterium ulcerans	ketoacyl reductase	0.0056	0.875	1
Leishmania major	hypothetical protein, conserved	0.0056	0.875	1
Brugia malayi	oxidoreductase	0.0056	0.875	0.875
Mycobacterium tuberculosis	Possible fatty acyl-CoA reductase	0.0056	0.875	1
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0056	0.875	1
Mycobacterium ulcerans	short-chain membrane-associated dehydrogenase	0.0056	0.875	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.875
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.0056	0.875	1
Mycobacterium tuberculosis	Possible oxidoreductase	0.0056	0.875	1
Schistosoma mansoni	steroid dehydrogenase	0.0056	0.875	1
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0056	0.875	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.875	1
Onchocerca volvulus		0.0056	0.875	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0056	0.875	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0056	0.875	1
Onchocerca volvulus		0.0056	0.875	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.875	1
Echinococcus multilocularis	retinol dehydrogenase 11	0.0056	0.875	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.875
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.0056	0.875	0.5
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0056	0.875	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.875	0.875
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0056	0.875	0.875
Loa Loa (eye worm)	oxidoreductase	0.0056	0.875	0.875
Giardia lamblia	Reductase, putative	0.0056	0.875	1
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.0056	0.875	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.875	0.875
Leishmania major	pteridine reductase 1	0.0056	0.875	1
Schistosoma mansoni	short chain dehydrogenase	0.0056	0.875	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0056	0.875	1
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0056	0.875	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.875
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0056	0.875	1
Echinococcus granulosus	carbonyl reductase 1	0.0056	0.875	1
Schistosoma mansoni	steroid dehydrogenase	0.0056	0.875	1
Mycobacterium leprae	Probable oxidoreductase	0.0056	0.875	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0056	0.875	1
Schistosoma mansoni	short chain dehydrogenase	0.0056	0.875	1
Giardia lamblia	Hypothetical protein	0.0056	0.875	1
Loa Loa (eye worm)	oxidoreductase	0.0056	0.875	0.875
Leishmania major	3-keto-dihydrosphingosine reductase	0.0056	0.875	1
Entamoeba histolytica	short chain dehydrogenase family protein	0.0056	0.875	1
Onchocerca volvulus		0.0056	0.875	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Mycobacterium tuberculosis	Possible oxidoreductase	0.0056	0.875	1
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0056	0.875	0.875
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0056	0.875	0.5
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.0056	0.875	0.5
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0056	0.875	1
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0056	0.875	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.875	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.875
Echinococcus granulosus	oxidoreductase	0.0056	0.875	1
Mycobacterium ulcerans	oxidoreductase	0.0056	0.875	1
Mycobacterium tuberculosis	Possible ketoacyl reductase	0.0056	0.875	1
Leishmania major	quinonoid dihydropteridine reductase	0.0056	0.875	1
Leishmania major	short chain dehydrogenase, putative	0.0056	0.875	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.875
Leishmania major	quinonoid dihydropteridine reductase	0.0056	0.875	1
Echinococcus multilocularis	steroid dehydrogenase	0.0056	0.875	1
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0056	0.875	1
Schistosoma mansoni	short chain dehydrogenase	0.0056	0.875	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.875	0.875
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.875
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0056	0.875	1
Schistosoma mansoni	steroid dehydrogenase	0.0056	0.875	1
Loa Loa (eye worm)	oxidoreductase	0.0056	0.875	0.875
Toxoplasma gondii	sterol carrier protein-2 HAD-2SCP-2	0.0056	0.875	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0056	0.875	1
Schistosoma mansoni	short chain dehydrogenase	0.0056	0.875	1
Brugia malayi	Dehydrogenases, short chain protein 2	0.0056	0.875	0.875
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0056	0.875	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.875	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.875	1
Leishmania major	quinonoid dihydropteridine reductase	0.0056	0.875	1
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.0056	0.875	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.875
Schistosoma mansoni	short chain dehydrogenase	0.0056	0.875	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.0056	0.875	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0056	0.875	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.875	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.875	1
Plasmodium vivax	hypothetical protein, conserved	0.0056	0.875	0.5
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.0056	0.875	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.875
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0056	0.875	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0056	0.875	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0056	0.875	1
Schistosoma mansoni	carbonyl reductase	0.0056	0.875	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0056	0.875	0.5
Echinococcus granulosus	retinol dehydrogenase 11	0.0056	0.875	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	0.875	1
Mycobacterium ulcerans	short-chain dehydrogenase	0.0056	0.875	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.875
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0056	0.875	1
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.0056	0.875	1
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0056	0.875	1
Loa Loa (eye worm)	oxidoreductase	0.0056	0.875	0.875
Echinococcus multilocularis	carbonyl reductase 1	0.0056	0.875	1
Echinococcus granulosus	hypothetical protein	0.0056	0.875	1
Mycobacterium ulcerans	ketoacyl reductase	0.0056	0.875	1
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0056	0.875	1
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0056	0.875	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.875
Toxoplasma gondii	carbonyl reductase 1, putative	0.0056	0.875	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0056	0.875	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.875	1
Onchocerca volvulus		0.0056	0.875	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.875
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0056	0.875	1
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	0.875	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0056	0.875	1
Onchocerca volvulus		0.0056	0.875	0.5
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.0056	0.875	1
Schistosoma mansoni	steroid dehydrogenase	0.0056	0.875	1
Echinococcus multilocularis	retinol dehydrogenase 13	0.0056	0.875	1
Mycobacterium ulcerans	carveol-like dehydrogenase	0.0056	0.875	1
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0056	0.875	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.875	1
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0056	0.875	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.875	0.875
Schistosoma mansoni	short chain dehydrogenase	0.0056	0.875	1
Echinococcus granulosus	WW domain containing oxidoreductase	0.0056	0.875	1
Mycobacterium tuberculosis	Probable short-chain dehydrogenase/reductase	0.0056	0.875	1
Mycobacterium tuberculosis	Probable short chain alcohol dehydrogenase/reductase	0.0056	0.875	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0056	0.875	1
Echinococcus granulosus	steroid dehydrogenase	0.0056	0.875	1
Brugia malayi	hypothetical protein	0.0056	0.875	0.875
Schistosoma mansoni	steroid dehydrogenase	0.0056	0.875	1
Toxoplasma gondii	3-ketoacyl-CoA reductase, putative	0.0056	0.875	0.5
Trypanosoma brucei	oxidoreductase-like protein	0.0056	0.875	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	1	1
Leishmania major	hypothetical protein, conserved	0.0056	0.875	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.875	0.875
Schistosoma mansoni	short chain dehydrogenase	0.0056	0.875	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0056	0.875	1
Schistosoma mansoni	short chain dehydrogenase	0.0056	0.875	1
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0056	0.875	1
Loa Loa (eye worm)	dehydrogenase	0.0056	0.875	0.875
Mycobacterium tuberculosis	Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1	0.0056	0.875	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Echinococcus multilocularis	transient receptor potential cation channel	0.0056	0.875	1
Echinococcus multilocularis	carbonyl reductase 1	0.0056	0.875	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0056	0.875	1
Entamoeba histolytica	hypothetical protein, conserved	0.0056	0.875	1
Mycobacterium ulcerans	dehydrogenase/decarboxylase protein	0.0056	0.875	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0056	0.875	1
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0056	0.875	1
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0056	0.875	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.875	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0056	0.875	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.875	0.875
Mycobacterium tuberculosis	Probable oxidoreductase	0.0056	0.875	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.875	1
Schistosoma mansoni	short chain dehydrogenase	0.0056	0.875	1
Loa Loa (eye worm)	hypothetical protein	0.006	1	1
Leishmania major	oxidoreductase-like protein	0.0056	0.875	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.875	0.875
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0056	0.875	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0056	0.875	1
Echinococcus granulosus	hypothetical protein	0.0056	0.875	1
Echinococcus multilocularis	conserved hypothetical protein	0.0056	0.875	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.875
Onchocerca volvulus		0.0056	0.875	0.5
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0056	0.875	1
Leishmania major	short chain dehydrogenase/reductase, putative	0.0056	0.875	1
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0056	0.875	0.875
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0056	0.875	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0056	0.875	1
Schistosoma mansoni	short chain dehydrogenase	0.0056	0.875	1
Schistosoma mansoni	steroid dehydrogenase	0.0056	0.875	1
Leishmania major	short chain dehydrogenase, putative	0.0056	0.875	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.875	0.875
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0056	0.875	1
Leishmania major	hypothetical protein, conserved	0.0056	0.875	1
Schistosoma mansoni	retinal dehydrogenase	0.0056	0.875	1
Leishmania major	quinonoid dihydropteridine reductase	0.0056	0.875	1
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.0056	0.875	1
Mycobacterium tuberculosis	Probable shortchain dehydrogenase	0.0056	0.875	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0056	0.875	1
Schistosoma mansoni	short chain dehydrogenase	0.0056	0.875	1
Schistosoma mansoni	short chain dehydrogenase	0.0056	0.875	1
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0056	0.875	1
Mycobacterium tuberculosis	Probable short-chain type oxidoreductase	0.0056	0.875	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.875	1
Loa Loa (eye worm)	dehydrogenase	0.0056	0.875	0.875
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0056	0.875	1
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0056	0.875	0.875
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Loa Loa (eye worm)	oxidoreductase	0.0056	0.875	0.875
Loa Loa (eye worm)	hypothetical protein	0.0041	0.4837	0.4837
Echinococcus multilocularis	oxidoreductase	0.0056	0.875	1
Entamoeba histolytica	hypothetical protein, conserved	0.0056	0.875	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0056	0.875	1
Schistosoma mansoni	short chain dehydrogenase	0.0056	0.875	1
Schistosoma mansoni	short chain dehydrogenase	0.0056	0.875	1
Plasmodium falciparum	oxidoreductase, short-chain dehydrogenase family, putative	0.0056	0.875	0.5
Entamoeba histolytica	short chain dehydrogenase family protein	0.0056	0.875	1
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0056	0.875	1
Entamoeba histolytica	hypothetical protein	0.0056	0.875	1
Loa Loa (eye worm)	oxidoreductase	0.0056	0.875	0.875
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0056	0.875	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0056	0.875	0.875
Echinococcus multilocularis	retinol dehydrogenase 11	0.0056	0.875	1
Toxoplasma gondii	oxidoreductase, putative	0.0056	0.875	0.5
Entamoeba histolytica	3-ketodihydrosphingosine reductase protein, putative	0.0056	0.875	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Brugia malayi	Retinol dehydrogenase 12	0.0056	0.875	0.875
Mycobacterium ulcerans	dehydrogenase/reductase	0.0056	0.875	1
Leishmania major	quinonoid dihydropteridine reductase	0.0056	0.875	1
Mycobacterium ulcerans	oxidoreductase	0.0056	0.875	1
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0056	0.875	1
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.0056	0.875	1
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.0056	0.875	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0056	0.875	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0056	0.875	1
Schistosoma mansoni	short chain dehydrogenase	0.0056	0.875	1
Brugia malayi	Dehydrogenases, short chain protein 30	0.0056	0.875	0.875
Plasmodium falciparum	steroid dehydrogenase, putative	0.0056	0.875	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0056	0.875	1
Schistosoma mansoni	steroid dehydrogenase	0.0056	0.875	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0056	0.875	1
Schistosoma mansoni	hypothetical protein	0.0041	0.4837	0.5528
Loa Loa (eye worm)	hypothetical protein	0.0056	0.875	0.875
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0056	0.875	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3091596

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1823581