Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0135 | 0.0135 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0074 | 0.2168 | 1 |
Schistosoma mansoni | alpha-amylase | 0.0312 | 1 | 1 |
Loa Loa (eye worm) | alpha amylase | 0.0312 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0074 | 0.2168 | 1 |
Toxoplasma gondii | glycosyltransferase | 0.0074 | 0.2168 | 0.5 |
Entamoeba histolytica | oligo-1,6-glucosidase, putative | 0.0312 | 1 | 1 |
Giardia lamblia | 1,4-alpha-glucan branching enzyme | 0.0074 | 0.2168 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0986 | 0.0986 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0135 | 0.0135 |
Brugia malayi | 1,4-alpha-glucan branching enzyme | 0.0074 | 0.2168 | 0.2168 |
Echinococcus multilocularis | alpha glucosidase | 0.0312 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0074 | 0.2168 | 1 |
Chlamydia trachomatis | 1,4-alpha-glucan branching enzyme | 0.0074 | 0.2168 | 0.5 |
Echinococcus granulosus | alpha glucosidase | 0.0312 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.118 | 0.118 |
Schistosoma mansoni | alpha-amylase | 0.0312 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0074 | 0.2168 | 1 |
Loa Loa (eye worm) | alpha amylase | 0.0312 | 1 | 1 |
Echinococcus granulosus | glucan 14 alpha branching enzyme 1 | 0.0074 | 0.2168 | 0.2168 |
Toxoplasma gondii | alpha amylase, catalytic domain-containing protein | 0.0074 | 0.2168 | 0.5 |
Trichomonas vaginalis | starch branching enzyme II, putative | 0.0074 | 0.2168 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0074 | 0.2168 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0074 | 0.2168 | 1 |
Echinococcus multilocularis | trehalose 6 phosphate hydrolase | 0.0074 | 0.2168 | 0.2168 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0135 | 0.0135 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0135 | 0.0135 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0074 | 0.2168 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0074 | 0.2168 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0135 | 0.0135 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.1315 | 0.1315 |
Schistosoma mansoni | starch branching enzyme II | 0.0074 | 0.2168 | 0.2168 |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0312 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0135 | 0.0135 |
Schistosoma mansoni | alpha-amylase | 0.0312 | 1 | 1 |
Trichomonas vaginalis | amylase, putative | 0.0074 | 0.2168 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.2168 | 0.2168 |
Mycobacterium tuberculosis | Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas | 0.0312 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1083 | 0.4996 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0074 | 0.2168 | 1 |
Echinococcus granulosus | trehalose 6 phosphate hydrolase | 0.0074 | 0.2168 | 0.2168 |
Schistosoma mansoni | alpha-amylase | 0.0312 | 1 | 1 |
Chlamydia trachomatis | glycogen hydrolase | 0.0074 | 0.2168 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.1315 | 0.1315 |
Mycobacterium leprae | Putative uncharacterized protein ML2045 | 0.0312 | 1 | 0.5 |
Mycobacterium ulcerans | trehalose synthase TreS | 0.0312 | 1 | 1 |
Trichomonas vaginalis | amylase, putative | 0.0074 | 0.2168 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0074 | 0.2168 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.118 | 0.118 |
Toxoplasma gondii | Alpha-amylase AMY3, putative | 0.0074 | 0.2168 | 0.5 |
Trichomonas vaginalis | amylase, putative | 0.0074 | 0.2168 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0074 | 0.2168 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.2168 | 0.2168 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0074 | 0.2168 | 1 |
Schistosoma mansoni | alpha-amylase | 0.0312 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0074 | 0.2168 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1083 | 0.4996 |
Mycobacterium tuberculosis | Trehalose synthase TreS | 0.0312 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0135 | 0.0135 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0135 | 0.0135 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.118 | 0.118 |
Trichomonas vaginalis | amylase, putative | 0.0074 | 0.2168 | 1 |
Toxoplasma gondii | 1,4-alpha-glucan-branching enzyme | 0.0074 | 0.2168 | 0.5 |
Echinococcus multilocularis | glucan (1,4 alpha), branching enzyme 1 | 0.0074 | 0.2168 | 0.2168 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0074 | 0.2168 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5590 nM | Displacement of [3H]astemizole from human ERG channel expressed in HEK293 cell membrane after 1 hr by scintillation counting analysis | ChEMBL. | 24224763 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.