Detailed information for compound 1824603

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 410.466 | Formula: C22H26N4O4
  • H donors: 3 H acceptors: 1 LogP: 1.45 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCOCCOCCOc1ccc(cc1)NC1=N/C(=C\c2ccccc2)/C(=O)N1
  • InChi: 1S/C22H26N4O4/c23-10-11-28-12-13-29-14-15-30-19-8-6-18(7-9-19)24-22-25-20(21(27)26-22)16-17-4-2-1-3-5-17/h1-9,16H,10-15,23H2,(H2,24,25,26,27)/b20-16-
  • InChiKey: CQNULDWOIXHYFM-SILNSSARSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 Starlite/ChEMBL References
Mus musculus CDC like kinase 4 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 9 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) References
Mus musculus CDC-like kinase 1 Starlite/ChEMBL References
Homo sapiens cyclin T1 References
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B Starlite/ChEMBL References
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Starlite/ChEMBL References
Mus musculus CDC-like kinase 3 Starlite/ChEMBL References
Homo sapiens cyclin A2 Starlite/ChEMBL References
Mus musculus CDC-like kinase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum ko:K02211 cyclin-dependent kinase 9, putative Get druggable targets OG5_130531 All targets in OG5_130531
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative Get druggable targets OG5_127439 All targets in OG5_127439
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131337 All targets in OG5_131337
Candida albicans weaker similarity to S. cerevisiae YAK1 (YJL141C) Get druggable targets OG5_127439 All targets in OG5_127439
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni kinase Get druggable targets OG5_130531 All targets in OG5_130531
Leishmania mexicana protein kinase, putative,dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative Get druggable targets OG5_127439 All targets in OG5_127439
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 Get druggable targets OG5_127439 All targets in OG5_127439
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase, putative,dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans weaker similarity to S. cerevisiae YAK1 (YJL141C) Get druggable targets OG5_127439 All targets in OG5_127439
Echinococcus granulosus cyclin dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase-like protein Get druggable targets OG5_127439 All targets in OG5_127439
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Giardia lamblia Kinase, CMGC DYRK Get druggable targets OG5_127439 All targets in OG5_127439
Schistosoma japonicum ko:K02211 cyclin-dependent kinase 9, putative Get druggable targets OG5_130531 All targets in OG5_130531
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase, putative,dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Neospora caninum hypothetical protein Get druggable targets OG5_127439 All targets in OG5_127439
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans similar ot C terminus of S. cerevisiae SGV1 (YPR161C) Get druggable targets OG5_130531 All targets in OG5_130531
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Echinococcus granulosus dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans CDC2-related protein kinase Get druggable targets OG5_130531 All targets in OG5_130531
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase, putative,dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_130531 All targets in OG5_130531
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130531 All targets in OG5_130531
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase Get druggable targets OG5_130531 All targets in OG5_130531
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cyclin-dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative Get druggable targets OG5_127439 All targets in OG5_127439
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 9 372 aa 313 aa 31.6 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase domain containing protein 0.022 0.6703 1
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0296 0.9417 1
Echinococcus granulosus cyclin dependent kinase 5 0.0109 0.2696 0.2387
Trypanosoma cruzi cdc2-related kinase 3 0.0109 0.2696 0.2514
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.3567 0.3788
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0296 0.9417 1
Loa Loa (eye worm) hypothetical protein 0.0309 0.9893 0.9889
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.006 0.0936 0.0519
Echinococcus multilocularis dual specificity 0.0133 0.3567 0.3309
Trichomonas vaginalis cyclins, putative 0.0046 0.0439 0.0466
Echinococcus multilocularis cyclin dependent kinase 1 0.0109 0.2696 0.2387
Entamoeba histolytica cell division protein kinase 2, putative 0.0119 0.3038 0.4149
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.022 0.6703 0.6977
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0309 0.9893 1
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0109 0.2696 0.2514
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.2696 0.2863
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0296 0.9417 0.939
Echinococcus granulosus cyclin dependent kinase 9 0.007 0.1277 0.0887
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0296 0.9417 1
Entamoeba histolytica protein kinase, putative 0.022 0.6703 1
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0109 0.2696 0.2387
Entamoeba histolytica cell division protein kinase 2, putative 0.0109 0.2696 0.3603
Echinococcus multilocularis cyclin dependent kinase 0.0109 0.2696 0.2387
Entamoeba histolytica protein kinase, putative 0.022 0.6703 1
Echinococcus multilocularis cyclin dependent kinase 9 0.006 0.0936 0.0525
Giardia lamblia Kinase, CMGC CDK 0.0109 0.2696 0.2514
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0109 0.2696 0.2514
Echinococcus granulosus dual specificity 0.0133 0.3567 0.3309
Brugia malayi cell division control protein 2 homolog 0.0109 0.2696 0.2514
Echinococcus multilocularis cyclin dependent kinase 5 0.0109 0.2696 0.2387
Trichomonas vaginalis cyclin B, putative 0.0046 0.0439 0.0466
Echinococcus multilocularis 0.029 0.9203 0.927
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0133 0.3567 0.3485
Entamoeba histolytica protein kinase domain containing protein 0.0133 0.3567 0.4995
Brugia malayi Protein kinase domain containing protein 0.022 0.6703 0.6977
Giardia lamblia Kinase, CMGC CLK 0.0296 0.9417 1
Brugia malayi cyclin-dependent kinase 9 0.006 0.0936 0.0553
Schistosoma mansoni serine/threonine protein kinase 0.0296 0.9417 0.9496
Loa Loa (eye worm) hypothetical protein 0.029 0.9203 0.9166
Loa Loa (eye worm) hypothetical protein 0.0148 0.4096 0.3825
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.3567 0.3788
Entamoeba histolytica hypothetical protein 0.022 0.6703 1
Leishmania major protein kinase, putative 0.0296 0.9417 1
Schistosoma mansoni serine/threonine protein kinase 0.0296 0.9417 0.9496
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0936 0.0793
Entamoeba histolytica protein kinase, putative 0.0133 0.3567 0.4995
Loa Loa (eye worm) hypothetical protein 0.0148 0.4096 0.3825
Brugia malayi Protein kinase domain containing protein 0.0296 0.9417 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.022 0.6703 0.6551
Echinococcus multilocularis cyclin dependent kinase 1 0.0109 0.2696 0.2387
Echinococcus granulosus cyclin dependent kinase 0.0109 0.2696 0.2387
Echinococcus granulosus dual specificity 0.0133 0.3567 0.3309
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 0.9893 1
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 0.9893 1
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.2696 0.2863
Loa Loa (eye worm) hypothetical protein 0.0103 0.2482 0.2137
Echinococcus multilocularis dual specificity 0.0133 0.3567 0.3309
Trichomonas vaginalis cyclins, putative 0.0046 0.0439 0.0466
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0296 0.9417 1
Echinococcus multilocularis dual specificity protein kinase clk2 0.0296 0.9417 0.9496
Echinococcus granulosus hypothetical protein 0.029 0.9203 0.927
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.3567 0.3309
Trichomonas vaginalis cyclins, putative 0.0046 0.0439 0.0466
Echinococcus granulosus cyclin dependent kinase 1 0.0109 0.2696 0.2387
Giardia lamblia Kinase, CMGC DYRK 0.0133 0.3567 0.3485
Trichomonas vaginalis CMGC family protein kinase 0.0296 0.9417 1
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0296 0.9417 1
Loa Loa (eye worm) hypothetical protein 0.0214 0.6489 0.6328
Echinococcus granulosus dual specificity 0.0133 0.3567 0.3309
Trypanosoma brucei cdc2-related kinase 3 0.0109 0.2696 0.2514
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.2696 0.2387
Trichomonas vaginalis cyclins, putative 0.0046 0.0439 0.0466
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.2696 0.2863
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.022 0.6703 0.6977
Leishmania major protein kinase, putative 0.0296 0.9417 1
Onchocerca volvulus 0.0046 0.0439 0.5
Echinococcus granulosus cyclin dependent kinase 9 0.006 0.0936 0.0525
Trypanosoma brucei cdc2-related kinase 1 0.0109 0.2696 0.2514
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0936 0.0525
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0296 0.9417 1
Loa Loa (eye worm) hypothetical protein 0.0214 0.6489 0.6328
Brugia malayi hypothetical protein 0.0148 0.4096 0.4074
Trichomonas vaginalis cyclin B, putative 0.0046 0.0439 0.0466
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0109 0.2696 0.236
Trypanosoma cruzi cdc2-related kinase 1 0.0109 0.2696 0.2514
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0133 0.3567 0.3485
Echinococcus granulosus dual specificity protein kinase clk2 0.0296 0.9417 0.9496
Giardia lamblia Kinase, CMGC CDK 0.0109 0.2696 0.2514
Echinococcus multilocularis dual specificity 0.0133 0.3567 0.3309
Trypanosoma cruzi cdc2-related kinase 3 0.0109 0.2696 0.2514
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0109 0.2696 0.236
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.022 0.6703 0.6977
Trichomonas vaginalis cyclin B, putative 0.0046 0.0439 0.0466
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.3567 0.3788
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0133 0.3567 0.3485
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0133 0.3567 0.1297
Trichomonas vaginalis cyclin B, putative 0.0046 0.0439 0.0466
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0109 0.2696 0.236
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.3567 0.3788
Schistosoma mansoni kinase 0.006 0.0936 0.0525
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.022 0.6703 0.6977
Trypanosoma cruzi cdc2-related kinase 1 0.0109 0.2696 0.2514
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0133 0.3567 0.3485
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0296 0.9417 1
Echinococcus granulosus dual specificity 0.022 0.6703 0.6625
Echinococcus multilocularis dual specificity 0.022 0.6703 0.6625
Brugia malayi Protein kinase domain containing protein 0.0109 0.2696 0.2514
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.2696 0.2387
Plasmodium falciparum protein serine/threonine kinase-1 0.0296 0.9417 1
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0133 0.3567 0.3272
Trichomonas vaginalis cyclin A, putative 0.0046 0.0439 0.0466
Schistosoma mansoni serine/threonine protein kinase 0.022 0.6703 0.6625
Echinococcus multilocularis cyclin dependent kinase 9 0.007 0.1277 0.0887
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.3567 0.3788
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.3567 0.3788
Plasmodium vivax serine/threonine kinase-1, putative 0.0296 0.9417 1

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Binding affinity to DYRK1A in mouse brain extracts by Western blot analysis ChEMBL. 23454515
IC50 (binding) = 8.5 uM Inhibition of human recombinant DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate ChEMBL. 23454515
IC50 (binding) > 10 uM Inhibition of human recombinant DYRK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate ChEMBL. 23454515
IC50 (binding) > 10 uM Inhibition of human recombinant DYRK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate ChEMBL. 23454515
IC50 (binding) > 10 uM Inhibition of human recombinant DYRK1B expressed in Escherichia coli using GRSRSRSRSRSR as substrate ChEMBL. 23454515
IC50 (binding) > 10 uM Inhibition of mouse recombinant CLK4 expressed in Escherichia coli using GRSRSRSRSRSR as substrate ChEMBL. 23454515
IC50 (binding) > 10 uM Inhibition of mouse recombinant CLK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate ChEMBL. 23454515
IC50 (binding) > 10 uM Inhibition of mouse recombinant CLK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate ChEMBL. 23454515
IC50 (binding) > 10 uM Inhibition of mouse recombinant CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate ChEMBL. 23454515
IC50 (binding) > 10 uM Inhibition of human recombinant CDK9/cyclin T using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate ChEMBL. 23454515
IC50 (binding) > 10 uM Inhibition of human recombinant CDK5/p25 using [gamma-33P]-ATP after 30 mins by scintillation counting ChEMBL. 23454515
IC50 (binding) > 10 uM Inhibition of human recombinant CDK2/cyclin A using [gamma-33P]-ATP after 30 mins by scintillation counting ChEMBL. 23454515

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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