Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.4235 | 1 | 1 |
Schistosoma mansoni | Hyaluronidase | 0.4235 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1799 | 0.3898 | 0.3876 |
Loa Loa (eye worm) | hyaluronidase | 0.4235 | 1 | 1 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.4235 | 1 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0258 | 0.0036 | 0.0036 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.0258 | 0.0036 | 0.5 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.0258 | 0.0036 | 0.5 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.4235 | 1 | 1 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.0258 | 0.0036 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.