Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuronal acetylcholine receptor; alpha4/beta2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha-amylase | 0.022 | 1 | 1 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Echinococcus granulosus | trehalose 6 phosphate hydrolase | 0.0053 | 0.1519 | 0.1519 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0053 | 0.1519 | 0.5 |
Echinococcus multilocularis | glucan (1,4 alpha), branching enzyme 1 | 0.0053 | 0.1519 | 0.1519 |
Mycobacterium leprae | Putative uncharacterized protein ML2045 | 0.022 | 1 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0053 | 0.1519 | 0.5 |
Mycobacterium ulcerans | trehalose synthase TreS | 0.022 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0053 | 0.1519 | 0.5 |
Toxoplasma gondii | glycosyltransferase | 0.0053 | 0.1519 | 0.5 |
Mycobacterium tuberculosis | Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas | 0.022 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0053 | 0.1519 | 0.5 |
Toxoplasma gondii | alpha amylase, catalytic domain-containing protein | 0.0053 | 0.1519 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.022 | 1 | 1 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Entamoeba histolytica | oligo-1,6-glucosidase, putative | 0.022 | 1 | 1 |
Trichomonas vaginalis | amylase, putative | 0.0053 | 0.1519 | 0.5 |
Brugia malayi | 1,4-alpha-glucan branching enzyme | 0.0053 | 0.1519 | 0.1519 |
Echinococcus multilocularis | alpha glucosidase | 0.022 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.1519 | 0.1519 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Giardia lamblia | 1,4-alpha-glucan branching enzyme | 0.0053 | 0.1519 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.022 | 1 | 1 |
Loa Loa (eye worm) | alpha amylase | 0.022 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0053 | 0.1519 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0053 | 0.1519 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0053 | 0.1519 | 0.5 |
Toxoplasma gondii | Alpha-amylase AMY3, putative | 0.0053 | 0.1519 | 0.5 |
Schistosoma mansoni | starch branching enzyme II | 0.0053 | 0.1519 | 0.1519 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0053 | 0.1519 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0053 | 0.1519 | 0.5 |
Onchocerca volvulus | Putative nachr subunit | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | trehalose 6 phosphate hydrolase | 0.0053 | 0.1519 | 0.1519 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0053 | 0.1519 | 0.5 |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.022 | 1 | 1 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Chlamydia trachomatis | glycogen hydrolase | 0.0053 | 0.1519 | 0.5 |
Trichomonas vaginalis | starch branching enzyme II, putative | 0.0053 | 0.1519 | 0.5 |
Trichomonas vaginalis | amylase, putative | 0.0053 | 0.1519 | 0.5 |
Echinococcus granulosus | glucan 14 alpha branching enzyme 1 | 0.0053 | 0.1519 | 0.1519 |
Loa Loa (eye worm) | alpha amylase | 0.022 | 1 | 1 |
Trichomonas vaginalis | amylase, putative | 0.0053 | 0.1519 | 0.5 |
Trichomonas vaginalis | amylase, putative | 0.0053 | 0.1519 | 0.5 |
Chlamydia trachomatis | 1,4-alpha-glucan branching enzyme | 0.0053 | 0.1519 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0053 | 0.1519 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1519 | 0.1519 |
Schistosoma mansoni | alpha-amylase | 0.022 | 1 | 1 |
Toxoplasma gondii | 1,4-alpha-glucan-branching enzyme | 0.0053 | 0.1519 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0053 | 0.1519 | 0.5 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Trichomonas vaginalis | alpha-amylase, putative | 0.0053 | 0.1519 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.022 | 1 | 1 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Mycobacterium tuberculosis | Trehalose synthase TreS | 0.022 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0053 | 0.1519 | 0.5 |
Echinococcus granulosus | alpha glucosidase | 0.022 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.8 uM | Displacement of [3H]epibatidine from rat alpha4beta2 nAChR transfected in HEK293 cells after 2 hrs by beta-plate counting analysis | ChEMBL. | 24274400 |
Ki (binding) | = 20.4 uM | Displacement of [3H]epibatidine from rat alpha3beta4 nAChR transfected in HEK293 cells after 2 hrs by beta-plate counting analysis | ChEMBL. | 24274400 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.