Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuronal acetylcholine receptor; alpha4/beta2 | Starlite/ChEMBL | References |
Rattus norvegicus | Neuronal acetylcholine receptor; alpha3/beta4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0076 | 0.1134 | 0.5 |
Mycobacterium ulcerans | trehalose synthase TreS | 0.0319 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0076 | 0.1134 | 0.5 |
Mycobacterium leprae | Putative uncharacterized protein ML2045 | 0.0319 | 1 | 0.5 |
Echinococcus multilocularis | glucan (1,4 alpha), branching enzyme 1 | 0.0076 | 0.1134 | 0.1134 |
Echinococcus granulosus | trehalose 6 phosphate hydrolase | 0.0076 | 0.1134 | 0.1134 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0076 | 0.1134 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0319 | 1 | 1 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Trichomonas vaginalis | amylase, putative | 0.0076 | 0.1134 | 0.5 |
Entamoeba histolytica | oligo-1,6-glucosidase, putative | 0.0319 | 1 | 1 |
Toxoplasma gondii | alpha amylase, catalytic domain-containing protein | 0.0076 | 0.1134 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Schistosoma mansoni | alpha-amylase | 0.0319 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0076 | 0.1134 | 0.5 |
Toxoplasma gondii | glycosyltransferase | 0.0076 | 0.1134 | 0.5 |
Mycobacterium tuberculosis | Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas | 0.0319 | 1 | 1 |
Schistosoma mansoni | alpha-amylase | 0.0319 | 1 | 1 |
Giardia lamblia | 1,4-alpha-glucan branching enzyme | 0.0076 | 0.1134 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.1134 | 0.1134 |
Echinococcus multilocularis | alpha glucosidase | 0.0319 | 1 | 1 |
Brugia malayi | 1,4-alpha-glucan branching enzyme | 0.0076 | 0.1134 | 0.1134 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0076 | 0.1134 | 0.5 |
Loa Loa (eye worm) | alpha amylase | 0.0319 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0076 | 0.1134 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0076 | 0.1134 | 0.5 |
Schistosoma mansoni | starch branching enzyme II | 0.0076 | 0.1134 | 0.1134 |
Toxoplasma gondii | Alpha-amylase AMY3, putative | 0.0076 | 0.1134 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0076 | 0.1134 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0076 | 0.1134 | 0.5 |
Trichomonas vaginalis | starch branching enzyme II, putative | 0.0076 | 0.1134 | 0.5 |
Chlamydia trachomatis | glycogen hydrolase | 0.0076 | 0.1134 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0319 | 1 | 1 |
Echinococcus multilocularis | trehalose 6 phosphate hydrolase | 0.0076 | 0.1134 | 0.1134 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0076 | 0.1134 | 0.5 |
Onchocerca volvulus | Putative nachr subunit | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.1134 | 0.1134 |
Chlamydia trachomatis | 1,4-alpha-glucan branching enzyme | 0.0076 | 0.1134 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0076 | 0.1134 | 0.5 |
Trichomonas vaginalis | amylase, putative | 0.0076 | 0.1134 | 0.5 |
Loa Loa (eye worm) | alpha amylase | 0.0319 | 1 | 1 |
Trichomonas vaginalis | amylase, putative | 0.0076 | 0.1134 | 0.5 |
Trichomonas vaginalis | amylase, putative | 0.0076 | 0.1134 | 0.5 |
Echinococcus granulosus | glucan 14 alpha branching enzyme 1 | 0.0076 | 0.1134 | 0.1134 |
Echinococcus granulosus | alpha glucosidase | 0.0319 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0076 | 0.1134 | 0.5 |
Mycobacterium tuberculosis | Trehalose synthase TreS | 0.0319 | 1 | 1 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Schistosoma mansoni | alpha-amylase | 0.0319 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0076 | 0.1134 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0076 | 0.1134 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Toxoplasma gondii | 1,4-alpha-glucan-branching enzyme | 0.0076 | 0.1134 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0319 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2.5 uM | Displacement of [3H]epibatidine from rat alpha4beta2 nAChR transfected in HEK293 cells after 2 hrs by beta-plate counting analysis | ChEMBL. | 24274400 |
Ki (binding) | = 14.4 uM | Displacement of [3H]epibatidine from rat alpha3beta4 nAChR transfected in HEK293 cells after 2 hrs by beta-plate counting analysis | ChEMBL. | 24274400 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.