Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kallikrein-related peptidase 7 | Starlite/ChEMBL | References |
Homo sapiens | kallikrein-related peptidase 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | kallikrein-related peptidase 7 | 181 aa | 186 aa | 32.8 % |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | kallikrein-related peptidase 5 | 293 aa | 290 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | alpha glucosidase | 0.0325 | 0.5 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0325 | 0.5 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0325 | 0.5 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0325 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas | 0.0325 | 0.5 | 0.5 |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0325 | 0.5 | 0.5 |
Echinococcus multilocularis | alpha glucosidase | 0.0325 | 0.5 | 0.5 |
Mycobacterium ulcerans | trehalose synthase TreS | 0.0325 | 0.5 | 0.5 |
Mycobacterium leprae | Putative uncharacterized protein ML2045 | 0.0325 | 0.5 | 0.5 |
Loa Loa (eye worm) | alpha amylase | 0.0325 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Trehalose synthase TreS | 0.0325 | 0.5 | 0.5 |
Loa Loa (eye worm) | alpha amylase | 0.0325 | 0.5 | 0.5 |
Entamoeba histolytica | oligo-1,6-glucosidase, putative | 0.0325 | 0.5 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0325 | 0.5 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0325 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.7 uM | Inhibition of human recombinant KLK5 expressed in baculovirus-infected insect cell system using Abz-KLRSSKQ-Eddnp as substrate incubated for 5 mins prior to substrate addition by FRET assay | ChEMBL. | 24900785 |
IC50 (binding) | = 16.6 uM | Inhibition of human recombinant KLK7 expressed in baculovirus-infected insect cell system using Abz-KLYSSKQ-Eddnp as substrate incubated for 5 mins prior to substrate addition by FRET assay | ChEMBL. | 24900785 |
Inhibition (binding) | Inhibition of human KLK1 at 1 to 500 uM after 5 mins by spectrophotometry | ChEMBL. | 24900785 | |
Inhibition (binding) | Inhibition of human KLK6 at 1 to 500 uM after 5 mins by spectrophotometry | ChEMBL. | 24900785 | |
Ki (binding) | = 0.3 uM | Competitive inhibition of human recombinant KLK5 expressed in baculovirus-infected insect cell system using Abz-KLRSSKQ-Eddnp as substrate incubated for 5 mins prior to substrate addition by Lineweaver-Burk plot analysis | ChEMBL. | 24900785 |
Ki (binding) | = 1.9 uM | Competitive inhibition of human recombinant KLK7 expressed in baculovirus-infected insect cell system using Abz-KLYSSKQ-Eddnp as substrate incubated for 5 mins prior to substrate addition by Lineweaver-Burk plot analysis | ChEMBL. | 24900785 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.