Detailed information for compound 183047

Basic information

Technical information
  • TDR Targets ID: 183047
  • Name: (5Z)-5-[(4-hydroxy-3,5-diiodophenyl)methylide ne]-1,3-thiazolidine-2,4-dione
  • MW: 473.026 | Formula: C10H5I2NO3S
  • H donors: 2 H acceptors: 3 LogP: 3.14 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)S/C/1=C\c1cc(I)c(c(c1)I)O
  • InChi: 1S/C10H5I2NO3S/c11-5-1-4(2-6(12)8(5)14)3-7-9(15)13-10(16)17-7/h1-3,14H,(H,13,15,16)/b7-3-
  • InChiKey: IUWAJFUOHMKIES-CLTKARDFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5Z)-5-[(4-hydroxy-3,5-diiodo-phenyl)methylene]thiazolidine-2,4-dione
  • (5Z)-5-[(4-hydroxy-3,5-diiodophenyl)methylene]thiazolidine-2,4-dione
  • (5Z)-5-[(4-hydroxy-3,5-diiodo-phenyl)methylidene]-1,3-thiazolidine-2,4-dione
  • (5Z)-5-(4-hydroxy-3,5-diiodo-benzylidene)thiazolidine-2,4-quinone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens N-acetyltransferase 1 (arylamine N-acetyltransferase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans arylamine N-acetyltransferase Nat Get druggable targets OG5_131280 All targets in OG5_131280
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) Get druggable targets OG5_131280 All targets in OG5_131280
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0119 0.0151
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1551 0.3806
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1551 0.3806
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0119 0.0299
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1551 0.3806
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0983 0.1399
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0119 0.0205
Schistosoma mansoni importin beta-1 0.0029 0.0234 0.0445
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0199 0.2495 1
Brugia malayi ecdysteroid receptor 0.002 0.0119 0.0205
Plasmodium falciparum importin beta, putative 0.0029 0.0234 1
Schistosoma mansoni patched 1 0.0085 0.0983 0.2358
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0534 0.0661
Onchocerca volvulus 0.0153 0.1884 0.303
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0119 0.0205
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0119 0.0205
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0132 0.1934
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0161 0.0048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0461 0.1024
Brugia malayi SET domain containing protein 0.0014 0.003 0.004
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0119 0.0299
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.065 0.1634
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0461 0.0833
Schistosoma mansoni nuclear hormone receptor 0.002 0.0119 0.0151
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0534 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0119 0.0299
Echinococcus granulosus expressed conserved protein 0.0187 0.2335 0.5869
Echinococcus granulosus Niemann Pick C1 protein 0.0284 0.3632 0.913
Trichomonas vaginalis chromobox protein, putative 0.007 0.0782 0.1068
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0119 0.0151
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.006 0.0096
Onchocerca volvulus 0.0012 0.0008 0.0012
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0119 0.0299
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0119 0.0151
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0461 0.0833
Plasmodium vivax SET domain protein, putative 0.006 0.065 1
Schistosoma mansoni hypothetical protein 0.031 0.3978 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0119 0.0205
Echinococcus granulosus chromobox protein 1 0.007 0.0782 0.1966
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0534 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0205
Echinococcus multilocularis Niemann Pick C1 protein 0.0284 0.3632 0.913
Echinococcus multilocularis Niemann Pick C1 protein 0.0199 0.2495 0.6273
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0119 0.0299
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0371 0.0393
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0205
Brugia malayi nuclear receptor NHR-88 0.002 0.0119 0.0205
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0306 0.055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0119 0.0205
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0119 0.0205
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.1551 0.2838
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0119 0.0205
Loa Loa (eye worm) RNA binding protein 0.0128 0.1551 0.2838
Echinococcus granulosus tar DNA binding protein 0.0128 0.1551 0.3899
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0119 0.0205
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0534 0.0661
Echinococcus multilocularis expressed conserved protein 0.0187 0.2335 0.5869
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0534 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0119 0.0205
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0119 0.0299
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0119 0.0205
Brugia malayi nuclear hormone receptor 0.002 0.0119 0.0205
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0371 0.0597
Onchocerca volvulus 0.0012 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0205
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0519 0.0941
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0371 0.0393
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0119 0.0205
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.065 0.1634
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0519 0.0941
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0218 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0119 0.0205
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0132 0.5487
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0534 0.0661
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.1551 0.2838
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0119 0.0205
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.065 0.1507
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0119 0.0205
Schistosoma mansoni hypothetical protein 0.0082 0.0942 0.2253
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0534 0.1342
Echinococcus multilocularis chromobox protein 1 0.007 0.0782 0.1966
Schistosoma mansoni thyroid hormone receptor 0.002 0.0119 0.0151
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0119 0.0151
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0534 0.121
Brugia malayi hypothetical protein 0.0153 0.1884 0.3451
Loa Loa (eye worm) hypothetical protein 0.0105 0.1239 0.2265
Schistosoma mansoni coup transcription factor 0.002 0.0119 0.0151
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0119 0.0205
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0983 0.2472
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0119 0.0151
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.3978 0.7302
Echinococcus granulosus FTZ F1 alpha 0.002 0.0119 0.0299
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0132 0.0331
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0534 0.8193
Brugia malayi Pre-SET motif family protein 0.006 0.065 0.1181
Schistosoma mansoni chromobox protein 0.007 0.0782 0.1844
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.006 0.0096
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0983 0.2472
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0119 0.0191
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0411 0.0459
Onchocerca volvulus 0.0479 0.6218 1
Schistosoma mansoni ran 0.0021 0.0132 0.0184
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0234 0.2541
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0119 0.0151
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0202 0.2536 0.6321
Echinococcus granulosus chromobox protein 1 0.007 0.0782 0.1966
Onchocerca volvulus 0.0012 0.0008 0.0012
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0234 0.2541
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0119 0.0299
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0534 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.006 0.0096
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0119 0.0151
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.0096
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0205
Schistosoma mansoni ran 0.0021 0.0132 0.0184
Echinococcus multilocularis chromobox protein 1 0.007 0.0782 0.1966
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0119 0.0299
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1551 0.3806
Onchocerca volvulus 0.0072 0.0803 0.1291
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0119 0.0205
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0461 0.1158
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0782 0.1424
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1551 0.3806
Loa Loa (eye worm) hypothetical protein 0.0051 0.0519 0.0941
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0132 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0119 0.0205
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0119 0.0299
Onchocerca volvulus 0.0012 0.0008 0.0012
Trypanosoma brucei protein kinase, putative 0.0052 0.0534 1
Loa Loa (eye worm) hypothetical protein 0.006 0.065 0.1181
Echinococcus granulosus snurportin 1 0.031 0.3978 1
Schistosoma mansoni hypothetical protein 0.0035 0.0306 0.063
Schistosoma mansoni hypothetical protein 0.0082 0.0942 0.2253
Onchocerca volvulus 0.0012 0.0008 0.0012
Trichomonas vaginalis set domain proteins, putative 0.0479 0.6218 1
Plasmodium vivax importin-beta 2, putative 0.0029 0.0234 0.3524
Echinococcus granulosus Niemann Pick C1 protein 0.0199 0.2495 0.6273
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0161 0.0048
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0132 0.0228
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0119 0.0191
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.006 0.015
Echinococcus multilocularis snurportin 1 0.031 0.3978 1
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0234 0.3524
Echinococcus granulosus importin subunit beta 1 0.0029 0.0234 0.0588
Schistosoma mansoni hypothetical protein 0.0082 0.0942 0.2253
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0461 0.1158
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0411 0.0661
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0119 0.0299
Echinococcus multilocularis protein patched 0.0085 0.0983 0.2472
Leishmania major importin beta-1 subunit, putative 0.0024 0.0161 0.0721
Schistosoma mansoni hypothetical protein 0.0171 0.2121 0.5261
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0119 0.0299
Brugia malayi TAR-binding protein 0.0128 0.1551 0.2838
Brugia malayi MH2 domain containing protein 0.0121 0.1456 0.2664
Brugia malayi MAP kinase sur-1 0.0052 0.0534 0.0968
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0421 0.5445 1
Onchocerca volvulus 0.0031 0.0258 0.0415
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0119 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0218 0.0142
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0119 0.0191
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.065 0.1507
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.065 0.1507
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0119 0.0299
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0119 0.0299
Schistosoma mansoni hypothetical protein 0.0171 0.2121 0.5261
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0132 0.1934
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0234 0.0588
Echinococcus multilocularis protein dispatched 1 0.0097 0.1144 0.2876
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0534 0.1342
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0072 0.0803 0.1897
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0205
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.062 0.156
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0461 0.1024
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.055
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0534 0.0968
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0119 0.0299
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0119 0.0205
Echinococcus multilocularis GPCR, family 2 0.0016 0.006 0.015
Echinococcus multilocularis geminin 0.0171 0.2121 0.5332
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0119 0.0299
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0534 0.1342
Schistosoma mansoni thyroid hormone receptor 0.002 0.0119 0.0151
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0161 0.0048
Brugia malayi Niemann-Pick C1 protein precursor 0.0199 0.2495 0.4575
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0461 0.1158
Echinococcus multilocularis tar DNA binding protein 0.0128 0.1551 0.3899
Onchocerca volvulus 0.0012 0.0008 0.0012
Brugia malayi steroid hormone receptor 0.002 0.0119 0.0205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0119 0.0205
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0534 0.1342
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1456 0.2664
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0519 0.0941
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0119 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0119 0.0205
Brugia malayi CHE-14 protein 0.0085 0.0983 0.1795
Echinococcus granulosus GPCR family 2 0.0016 0.006 0.015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0461 0.1024
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0534 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0234 0.0416
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0119 0.0205
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1456 0.2664
Onchocerca volvulus 0.002 0.0119 0.0191
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.006 0.015
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0119 0.0205
Echinococcus granulosus geminin 0.0171 0.2121 0.5332
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0461 0.1158
Brugia malayi RNA binding protein 0.0128 0.1551 0.2838
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0534 1
Entamoeba histolytica hypothetical protein 0.0024 0.0161 0.0123
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0534 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0132 0.0228
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0763 1 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0205
Trichomonas vaginalis chromobox protein, putative 0.007 0.0782 0.1068
Onchocerca volvulus 0.0012 0.0008 0.0012
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0411 0.0459
Onchocerca volvulus Protein patched homolog 0.0012 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0205
Brugia malayi chromobox protein homolog 3 0.0039 0.0371 0.0669
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0205
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.065 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0258 0.046
Brugia malayi Importin beta-1 subunit 0.0029 0.0234 0.0416
Loa Loa (eye worm) hypothetical protein 0.0199 0.2495 0.4575
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0983 0.2472
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0119 0.0205
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.006 0.015
Schistosoma mansoni hypothetical protein 0.0082 0.0942 0.2253
Loa Loa (eye worm) TAR-binding protein 0.0128 0.1551 0.2838
Schistosoma mansoni chromobox protein 0.007 0.0782 0.1844
Brugia malayi RNA, U transporter 1 0.0083 0.0947 0.1728
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0119 0.0299
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0534 0.0661
Brugia malayi Heterochromatin protein 1 0.007 0.0782 0.1424
Brugia malayi Pre-SET motif family protein 0.0421 0.5445 1
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.065 0.1634
Loa Loa (eye worm) hypothetical protein 0.0153 0.1884 0.3451
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0119 0.0299
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.006 0.015
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0534 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0983 0.1795
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0983 0.1795
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0119 0.0151
Loa Loa (eye worm) hypothetical protein 0.0039 0.0371 0.0669
Onchocerca volvulus Protein patched homolog 0.0012 0.0008 0.0012
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0161 0.0721

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) uM Inhibitory activity against 5-lipoxygenase in intact rat basophilic leukemia cells stimulated with the calciumionophore A-23,187; Inactive(N)= <50% inhibition at 10 microM ChEMBL. 8295221
IC50 (binding) N 0 uM Inhibitory activity against 5-lipoxygenase in intact rat basophilic leukemia cells stimulated with the calciumionophore A-23,187; Inactive(N)= <50% inhibition at 10 microM ChEMBL. 8295221
IC50 (binding) = 3.6 uM Inhibition of human recombinant NAT1 assessed as hydrolysis of acetyl coA using PABA as substrate by Ellman's method ChEMBL. 19059786
Inhibition (binding) = 60 % Inhibitory activity at 10 microM against Prostaglandin G/H synthase in intact rat basophilic leukemia cells stimulated with the calciumionophore A-23,187 ChEMBL. 8295221
Inhibition (binding) = 60 % Inhibitory activity at 10 microM against Prostaglandin G/H synthase in intact rat basophilic leukemia cells stimulated with the calciumionophore A-23,187 ChEMBL. 8295221

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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