Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | choline kinase alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | choline/ethanolamine kinase | choline kinase alpha | 457 aa | 474 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0685046 | 0.514247 | 0.295376 |
Brugia malayi | Matrixin family protein | 0.0317259 | 0.154155 | 0.299769 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.118118 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0685046 | 0.514247 | 0.514247 |
Onchocerca volvulus | Matrilysin homolog | 0.0291022 | 0.128467 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0685046 | 0.514247 | 0.514247 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0685046 | 0.514247 | 0.50144 |
Loa Loa (eye worm) | hypothetical protein | 0.0685046 | 0.514247 | 0.514247 |
Echinococcus granulosus | acetylcholinesterase | 0.0685046 | 0.514247 | 0.295376 |
Mycobacterium ulcerans | hydrolase | 0.015981 | 0 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0186047 | 0.0256885 | 0.0499535 |
Echinococcus granulosus | carboxylesterase 5A | 0.0685046 | 0.514247 | 0.295376 |
Loa Loa (eye worm) | hypothetical protein | 0.118118 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0685046 | 0.514247 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0685046 | 0.514247 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.118118 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0291022 | 0.128467 | 0.128467 |
Echinococcus multilocularis | acetylcholinesterase | 0.0685046 | 0.514247 | 0.295376 |
Echinococcus granulosus | hormone sensitive lipase | 0.118118 | 1 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0291022 | 0.128467 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0685046 | 0.514247 | 0.514247 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.015981 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0685046 | 0.514247 | 0.295376 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0685046 | 0.514247 | 0.295376 |
Loa Loa (eye worm) | matrixin family protein | 0.0317259 | 0.154155 | 0.154155 |
Echinococcus multilocularis | hormone sensitive lipase | 0.118118 | 1 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.015981 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.118118 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.007 uM | Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay | ChEMBL. | 25089811 |
IC50 (functional) | = 11.7 uM | Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay | ChEMBL. | 24387243 |
Kd (binding) | = 0.62 uM | Binding affinity to human CK-alpha1 by tryptophan fluorescence spectroscopic analysis | ChEMBL. | 24387243 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24387243 | |
Plasmodium falciparum | 25089811 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.