Detailed information for compound 183560

Basic information

Technical information
  • TDR Targets ID: 183560
  • Name: 5-[4-[3-(trifluoromethyl)phenyl]butyl]-1H-imi dazole
  • MW: 268.278 | Formula: C14H15F3N2
  • H donors: 1 H acceptors: 1 LogP: 4.1 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC(c1cccc(c1)CCCCc1c[nH]cn1)(F)F
  • InChi: 1S/C14H15F3N2/c15-14(16,17)12-6-3-5-11(8-12)4-1-2-7-13-9-18-10-19-13/h3,5-6,8-10H,1-2,4,7H2,(H,18,19)
  • InChiKey: BEIQLZSLCJDKHP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[4-[3-(trifluoromethyl)phenyl]butyl]-3H-imidazole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Histamine H3 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein Histamine H3 receptor   445 aa 384 aa 22.4 %
Echinococcus granulosus biogenic amine 5HT receptor Histamine H3 receptor   445 aa 405 aa 25.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0044 0.0147 0.268
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0028 0.0696
Onchocerca volvulus 0.0093 0.0479 0.233
Loa Loa (eye worm) GTP-binding protein 0.0149 0.0863 0.3302
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0201 0.0772
Toxoplasma gondii type I fatty acid synthase, putative 0.0039 0.0113 0.0429
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0401 0.2571 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0036 0.0094 0.1495
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0092 0.0473 0.183
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0048 0.0176 0.0672
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0081 0.0401 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0469 0.1759
Echinococcus multilocularis expressed protein 0.0399 0.256 0.9955
Brugia malayi eukaryotic translation initiation factor 4E-1 0.0048 0.0176 0.0672
Echinococcus multilocularis p2X purinoceptor 4 0.0279 0.1746 0.6787
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0092 0.0473 0.183
Echinococcus granulosus eukaryotic translation initiation factor 4E type 0.0048 0.0176 0.0672
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0292 0.1125
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0176 0.3316
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0092 0.0473 0.183
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0292 0.5928
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0058 0.0242 0.6033
Brugia malayi Eukaryotic translation initiation factor 4E type 3, putative 0.0048 0.0176 0.0672
Mycobacterium ulcerans Type I modular polyketide synthase 0.0054 0.0219 0.4294
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0195 0.0747
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0401 0.2571 1
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0048 0.0176 0.0672
Loa Loa (eye worm) hypothetical protein 0.0093 0.0479 0.1799
Loa Loa (eye worm) hypothetical protein 0.0253 0.1567 0.6063
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-3 0.0048 0.0176 0.0672
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0048 0.0176 0.0672
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0028 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0027 0.0037 0.0133
Leishmania major hypothetical protein, conserved 0.0048 0.0176 0.0672
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0092 0.0473 0.183
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0028 0.0097
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0054 0.0219 0.5463
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0401 0.2571 1
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0092 0.0473 0.183
Trypanosoma brucei Eukaryotic translation initiation factor 4E type 5 0.0048 0.0176 0.0672
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0401 0.2571 1
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0048 0.0176 0.0672
Trypanosoma brucei Eukaryotic translation initiation factor 4E-4 0.0048 0.0176 0.0672
Entamoeba histolytica translation initiation factor 4e, putative 0.0048 0.0176 0.058
Schistosoma mansoni P2X receptor subunit 0.0138 0.0791 0.0788
Plasmodium falciparum eukaryotic translation initiation factor 4E, putative 0.0048 0.0176 0.3316
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0044 0.0147 0.268
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.1567 0.609
Mycobacterium ulcerans polyketide synthase Pks9 0.0036 0.0094 0.1495
Plasmodium vivax telomerase reverse transcriptase, putative 0.0086 0.0436 0.916
Brugia malayi GTP-binding protein 0.0149 0.0863 0.3347
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0058 0.0242 0.4807
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0292 0.0289
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0093 0.0479 0.1855
Mycobacterium ulcerans polyketide synthase Pks13 0.0081 0.0401 0.838
Echinococcus granulosus p2X purinoceptor 4 0.0279 0.1746 0.6787
Brugia malayi Phosphoribosyl transferase domain containing protein 0.0092 0.0473 0.183
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0053 0.0208 0.5182
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0292 0.1125
Trichomonas vaginalis hypoxanthine-guanine phosphoribosyltransferase, putative 0.0092 0.0473 0.183
Brugia malayi translation initiation factor 4E 0.0401 0.2571 1
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0028 0.0097
Leishmania major xanthine phosphoribosyltransferase 0.0092 0.0473 0.183
Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT 0.0092 0.0473 0.183
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0092 0.0473 0.047
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0048 0.0176 0.0672
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0048 0.0176 0.0672
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0292 0.0289
Brugia malayi GTP-binding protein, identical 0.0149 0.0863 0.3347
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0028 0.0097
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0048 0.0176 0.0672
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0035 0.009 0.0338
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0048 0.0176 0.0672
Trypanosoma brucei telomerase reverse transcriptase 0.0086 0.0436 0.1685
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.1567 0.609
Mycobacterium tuberculosis Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor 0.007 0.0328 0.8167
Echinococcus multilocularis p2X purinoceptor 4 0.0279 0.1746 0.6787
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0028 0.0097
Loa Loa (eye worm) eukaryotic translation initiation factor 4E type 3 0.0048 0.0176 0.0608
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0401 0.2571 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0048 0.0176 0.0672
Brugia malayi Telomerase reverse transcriptase 0.0229 0.1407 0.5465
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.006 0.0221
Onchocerca volvulus Fatty acid synthase homolog 0.0098 0.0514 0.2501
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0058 0.0242 0.4807
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0048 0.0176 0.058
Mycobacterium ulcerans thioesterase 0.0045 0.0158 0.2917
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0292 0.5928
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0048 0.0176 0.0672
Schistosoma mansoni cell polarity protein 0.0149 0.0863 0.086
Trypanosoma brucei Eukaryotic translation initiation factor 4E-3 0.0048 0.0176 0.0672
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0054 0.0219 0.5124
Echinococcus granulosus L aminoadipate semialdehyde 0.0093 0.0479 0.1855
Onchocerca volvulus Putative eukaryotic translation initiation factor 4e 0.0048 0.0176 0.0844
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0401 0.2571 1
Plasmodium vivax translation initiation factor 4E, putative 0.0048 0.0176 0.3316
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0401 0.2571 1
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0401 0.2571 0.2569
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0048 0.0176 0.0672
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0048 0.0176 0.0672
Trypanosoma brucei Eukaryotic translation initiation factor 4E-2 0.0048 0.0176 0.0672
Echinococcus multilocularis p2X purinoceptor 4 0.0279 0.1746 0.6787
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0031 0.006 0.0221
Trypanosoma brucei ingi protein (ORF1) 0.0031 0.006 0.0221
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0048 0.0176 0.0672
Plasmodium falciparum telomerase reverse transcriptase 0.0086 0.0436 0.916
Onchocerca volvulus 0.0052 0.0201 0.0969
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0048 0.0176 0.058
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0086 0.0436 0.1685
Mycobacterium ulcerans hypoxanthine-guanine phosphoribosyltransferase Hpt 0.0092 0.0473 1
Toxoplasma gondii RNA-directed DNA polymerase 0.0086 0.0436 0.1685
Trichomonas vaginalis hypothetical protein 0.0048 0.0176 0.0672
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0045 0.0158 0.348
Echinococcus granulosus expressed protein 0.0399 0.256 0.9955
Mycobacterium tuberculosis Probable thioesterase TesA 0.0045 0.0158 0.3934
Echinococcus granulosus p2X purinoceptor 4 0.0279 0.1746 0.6787
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0031 0.006 0.1505
Giardia lamblia Guanine phosphoribosyltransferase 0.0092 0.0473 1
Giardia lamblia hypothetical protein 0.0048 0.0176 0.367
Leishmania major eukaryotic translation initiation factor, putative 0.0048 0.0176 0.0672
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0048 0.0176 0.0672
Mycobacterium ulcerans Type I modular polyketide synthase 0.0054 0.0219 0.4294
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase, putative 0.0092 0.0473 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0054 0.0219 0.5463
Mycobacterium ulcerans Type I modular polyketide synthase 0.0054 0.0219 0.4294
Entamoeba histolytica hypothetical protein 0.0048 0.0176 0.058
Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase 0.0092 0.0473 1
Onchocerca volvulus 0.0051 0.0195 0.0939
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0058 0.0242 0.5736
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0176 0.0672
Leishmania major telomerase reverse transcriptase, putative 0.0086 0.0436 0.1685
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0292 0.1125
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0039 0.0115 0.288
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0401 0.2571 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0054 0.0219 0.4294
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0093 0.0479 0.0477
Schistosoma mansoni cell polarity protein 0.0149 0.0863 0.086
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0401 0.2571 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0292 0.7278
Toxoplasma gondii hypothetical protein 0.0048 0.0176 0.0672
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0028 1
Leishmania major eukaryotic translation initiation factor-like 0.0401 0.2571 1
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0092 0.0473 0.183
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0048 0.0176 0.0672
Mycobacterium leprae Polyketide synthase Pks13 0.0081 0.0401 1
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0048 0.0176 0.058
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0048 0.0176 0.0672
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0324 0.2048 1
Schistosoma mansoni P2X receptor subunit 0.0279 0.1746 0.1744
Schistosoma mansoni P2X receptor subunit 0.0279 0.1746 0.1744
Echinococcus granulosus ras gtpase 0.0149 0.0863 0.3347
Mycobacterium ulcerans polyketide synthase 0.0054 0.0219 0.4294
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0058 0.0242 0.6033
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0044 0.0152 0.3792
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0103 0.0548 0.2124
Giardia lamblia Telomerase catalytic subunit 0.0086 0.0436 0.9204
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0092 0.0473 0.047
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0401 0.2571 1
Plasmodium falciparum eukaryotic translation initiation factor 4E 0.0048 0.0176 0.3316
Trypanosoma brucei RNA helicase, putative 0.0369 0.2359 0.9171
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0086 0.0436 0.1685
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0176 0.0672
Echinococcus multilocularis ras gtpase 0.0149 0.0863 0.3347
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0036 0.0094 0.1784
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0292 0.5928
Loa Loa (eye worm) hypothetical protein 0.003 0.0057 0.0145
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0092 0.0473 0.183
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0028 0.5
Schistosoma mansoni survival motor neuron protein 0.0052 0.0201 0.0198
Mycobacterium ulcerans thioesterase TesA 0.0045 0.0158 0.2917
Loa Loa (eye worm) eukaryotic translation initiation factor 4E-1 0.0048 0.0176 0.0608
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0092 0.0473 0.183
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0054 0.0219 0.0841
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0051 0.0195 0.4861
Mycobacterium leprae Probable polyketide synthase Pks1 0.0058 0.0242 0.5736
Echinococcus multilocularis L aminoadipate semialdehyde 0.0093 0.0479 0.1855
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0401 0.2571 1
Mycobacterium ulcerans polyketide synthase 0.0058 0.0242 0.4807
Leishmania major hypothetical protein, conserved 0.0048 0.0176 0.0672
Trypanosoma brucei unspecified product 0.0031 0.006 0.0221
Brugia malayi hypothetical protein 0.0253 0.1567 0.609
Giardia lamblia Hypothetical protein 0.0048 0.0176 0.367
Onchocerca volvulus 0.0092 0.0473 0.2299
Loa Loa (eye worm) translation initiation factor 4E 0.0401 0.2571 1
Schistosoma mansoni hypothetical protein 0.0369 0.2359 0.2356
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0292 0.1125
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0048 0.0176 0.058
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0054 0.0219 0.5463
Trypanosoma brucei ingi protein (ORF1) 0.0031 0.006 0.0221
Leishmania major eukaryotic translation initiation factor-like protein 0.0401 0.2571 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0048 0.0176 0.0672
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0048 0.0176 0.0672
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0054 0.0219 0.5124
Schistosoma mansoni P2X receptor subunit 0.0138 0.0791 0.0788
Leishmania major hypoxanthine-guanine phosphoribosyltransferase 0.0092 0.0473 0.183
Entamoeba histolytica hypothetical protein 0.0048 0.0176 0.058
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0092 0.0473 0.183
Giardia lamblia Translation elongation factor 0.0048 0.0176 0.367
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0048 0.0176 0.0672
Toxoplasma gondii type I fatty acid synthase, putative 0.0058 0.0242 0.093
Mycobacterium leprae Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho 0.007 0.0328 0.803
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0058 0.0242 0.5736
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0058 0.0242 0.6033
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase, putative 0.0092 0.0473 0.183
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0081 0.0401 1
Giardia lamblia Hypothetical protein 0.0048 0.0176 0.367
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0048 0.0176 0.058
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0053 0.0208 0.5182
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0176 0.0672
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0401 0.2571 1
Schistosoma mansoni hypothetical protein 0.0052 0.0201 0.0198
Onchocerca volvulus 0.0094 0.0491 0.2389
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0051 0.0195 0.0684
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0401 0.2571 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0044 0.0147 0.3198
Echinococcus granulosus p2X purinoceptor 4 0.0279 0.1746 0.6787
Loa Loa (eye worm) fatty acid synthase 0.0053 0.0214 0.076
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0048 0.0176 0.0672
Leishmania major eukaryotic translation initiation factor 4e, putative 0.0048 0.0176 0.0672
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0092 0.0473 0.183

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 6.5 mg kg-1 In vivo inhibition of brain N-methylhistamine formation in mice when administered perorally in presence of oxalate salt ChEMBL. 15163206
ED50 (functional) = 6.5 mg kg-1 In vivo inhibition of brain N-methylhistamine formation in mice when administered perorally in presence of oxalate salt ChEMBL. 15163206
Intrinsic activity (functional) = 0 Intrinsic activity was determined inhibition of brain N-mehtylhistamine formation in mice relative to imetit ChEMBL. 15163206
Ki (binding) = 38 nM In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes ChEMBL. 15163206
Ki (binding) = 38 nM In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes ChEMBL. 15163206

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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