Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neuropeptide Y receptor Y5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cyclin, putative | 0.0035 | 0.1582 | 0.1582 |
Trypanosoma cruzi | cyclin 6, putative | 0.0035 | 0.1582 | 0.1582 |
Giardia lamblia | Cyclin A | 0.0035 | 0.1582 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0035 | 0.1582 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0035 | 0.1582 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0062 | 0.3288 | 0.2026 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.3288 | 0.2026 |
Trichomonas vaginalis | cyclins, putative | 0.0035 | 0.1582 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0062 | 0.3288 | 0.2026 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0062 | 0.3288 | 0.2026 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0.1582 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0062 | 0.3288 | 0.2026 |
Toxoplasma gondii | hypothetical protein | 0.0062 | 0.3288 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0035 | 0.1582 | 0.5 |
Entamoeba histolytica | cyclin family protein | 0.0035 | 0.1582 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0062 | 0.3288 | 0.2026 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0062 | 0.3288 | 0.2026 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0035 | 0.1582 | 0.1582 |
Entamoeba histolytica | cyclin, putative | 0.0035 | 0.1582 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.3288 | 0.2026 |
Schistosoma mansoni | fatty acid desaturase | 0.0102 | 0.59 | 0.513 |
Trichomonas vaginalis | cyclins, putative | 0.0035 | 0.1582 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.3288 | 0.2026 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0062 | 0.3288 | 0.2026 |
Loa Loa (eye worm) | FAT-3 protein | 0.0102 | 0.588 | 0.5105 |
Schistosoma mansoni | carbonic anhydrase | 0.0062 | 0.3288 | 0.2026 |
Leishmania major | cyclin | 0.0035 | 0.1582 | 0.1582 |
Echinococcus multilocularis | carbonic anhydrase | 0.0062 | 0.3288 | 0.2026 |
Trichomonas vaginalis | cyclin D, putative | 0.0035 | 0.1582 | 0.5 |
Entamoeba histolytica | cyclin family protein | 0.0035 | 0.1582 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0062 | 0.3288 | 0.2026 |
Echinococcus granulosus | carbonic anhydrase | 0.0062 | 0.3288 | 0.2026 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0062 | 0.3288 | 0.2026 |
Onchocerca volvulus | 0.0102 | 0.59 | 1 | |
Trichomonas vaginalis | cyclin B3, putative | 0.0035 | 0.1582 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0035 | 0.1582 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0035 | 0.1582 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.3288 | 0.2026 |
Leishmania major | delta-5 fatty acid desaturase | 0.0102 | 0.588 | 0.588 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0035 | 0.1582 | 0.1582 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.588 | 0.5105 |
Entamoeba histolytica | cyclin, putative | 0.0035 | 0.1582 | 0.5 |
Trichomonas vaginalis | cyclin A, putative | 0.0035 | 0.1582 | 0.5 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0102 | 0.588 | 0.5105 |
Trypanosoma cruzi | cyclin, putative | 0.0035 | 0.1582 | 0.1582 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0062 | 0.3288 | 0.2026 |
Trichomonas vaginalis | cyclin B, putative | 0.0035 | 0.1582 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.5224 | 0.4326 |
Trichomonas vaginalis | cyclins, putative | 0.0035 | 0.1582 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0035 | 0.1582 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0062 | 0.3288 | 1 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0035 | 0.1582 | 0.1582 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0062 | 0.3288 | 0.2026 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0035 | 0.1582 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0035 | 0.1582 | 0.5 |
Trichomonas vaginalis | cyclin D, putative | 0.0035 | 0.1582 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0062 | 0.3288 | 0.2026 |
Echinococcus granulosus | carbonic anhydrase | 0.0062 | 0.3288 | 0.2026 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 27 nM | Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes. | ChEMBL. | 10669561 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.