Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | zinc-type alcohol dehydrogenase AdhD | 0.015 | 0.4669 | 0.4669 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) | 0.015 | 0.4669 | 0.5047 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0102 | 0.0218 |
Plasmodium vivax | hypothetical protein, conserved | 0.0021 | 0.0102 | 0.5 |
Schistosoma mansoni | alcohol dehydrogenase | 0.015 | 0.4669 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0021 | 0.0102 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0021 | 0.0102 | 0.0102 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0021 | 0.0102 | 1 |
Loa Loa (eye worm) | alcohol dehydrogenase class III | 0.015 | 0.4669 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0021 | 0.0102 | 1 |
Echinococcus multilocularis | 0.0021 | 0.0102 | 1 | |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0021 | 0.0102 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0021 | 0.0102 | 0.0218 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0102 | 0.0218 |
Toxoplasma gondii | Zn-containing alcohol dehydrogenase | 0.015 | 0.4669 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0021 | 0.0102 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0021 | 0.0102 | 0.011 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0021 | 0.0102 | 0.0102 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0102 | 0.0218 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 | 0.0132 | 0.402 | 0.4346 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0021 | 0.0102 | 1 |
Schistosoma mansoni | amine oxidase | 0.0021 | 0.0102 | 0.0218 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0021 | 0.0102 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0102 | 0.0218 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0021 | 0.0102 | 0.0218 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0021 | 0.0102 | 0.0218 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0021 | 0.0102 | 1 |
Onchocerca volvulus | 0.0021 | 0.0102 | 0.0218 | |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0021 | 0.0102 | 0.0218 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase | 0.015 | 0.4669 | 0.4669 |
Mycobacterium ulcerans | monoamine oxidase | 0.0021 | 0.0102 | 0.0102 |
Onchocerca volvulus | Putative alcohol dehydrogenase | 0.015 | 0.4669 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0021 | 0.0102 | 0.0218 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0021 | 0.0102 | 0.5 |
Mycobacterium tuberculosis | Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0132 | 0.402 | 0.4346 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0102 | 0.0218 |
Leishmania major | UDP-galactopyranose mutase | 0.0021 | 0.0102 | 1 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0021 | 0.0102 | 0.5 |
Mycobacterium leprae | Probable S-nitrosomycothiol reductase MscR | 0.015 | 0.4669 | 1 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase AdhE2 | 0.015 | 0.4669 | 0.4669 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0021 | 0.0102 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0021 | 0.0102 | 0.5 |
Mycobacterium ulcerans | dehydrogenase | 0.0021 | 0.0102 | 0.0102 |
Brugia malayi | SWIRM domain containing protein | 0.0021 | 0.0102 | 0.0218 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.028 | 0.925 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0102 | 0.0218 |
Brugia malayi | Alcohol dehydrogenase class III | 0.015 | 0.4669 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0021 | 0.0102 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.0102 | 0.011 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD-dependent AdhB | 0.015 | 0.4669 | 0.4669 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0102 | 0.0218 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0021 | 0.0102 | 0.0218 |
Schistosoma mansoni | amine oxidase | 0.0021 | 0.0102 | 0.0218 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.015 | 0.4669 | 0.4669 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.