Detailed information for compound 1841226

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 364.399 | Formula: C14H12N4O4S2
  • H donors: 2 H acceptors: 5 LogP: 1.32 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)c1nnc(s1)NC(=O)CC1SC(=O)NC1=O
  • InChi: 1S/C14H12N4O4S2/c1-22-8-4-2-3-7(5-8)12-17-18-13(24-12)15-10(19)6-9-11(20)16-14(21)23-9/h2-5,9H,6H2,1H3,(H,15,18,19)(H,16,20,21)
  • InChiKey: AJILCJHLKNHNAS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus RUN 0.0223 0.3005 0.2943
Schistosoma mansoni heat shock protein 0.0033 0.0188 0.0083
Echinococcus granulosus aldo keto reductase 0.0067 0.07 0.0617
Loa Loa (eye worm) hypothetical protein 0.0227 0.3063 0.3481
Trypanosoma cruzi aldo/keto reductase, putative 0.0067 0.07 1
Echinococcus multilocularis microtubule associated protein 2 0.0694 1 1
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0224 0.0716
Brugia malayi Endoplasmin precursor 0.0033 0.0188 0.0097
Schistosoma mansoni aldo-keto reductase 0.0067 0.07 0.0602
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0601 0.8616 0.8601
Schistosoma mansoni loxhd1 0.0223 0.3005 0.2931
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0067 0.07 0.07
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0624 0.895 0.8941
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0224 0.0746
Brugia malayi hypothetical protein 0.0223 0.3005 0.3408
Trichomonas vaginalis guanylate cyclase, putative 0.0031 0.0164 0.2344
Echinococcus granulosus aldehyde reductase 0.0048 0.0411 0.0326
Giardia lamblia Aldose reductase 0.0067 0.07 1
Onchocerca volvulus Huntingtin homolog 0.0123 0.1531 0.4169
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0188 0.1615
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.0502 0.7146 1
Loa Loa (eye worm) hypothetical protein 0.0258 0.3524 0.4023
Loa Loa (eye worm) doublecortin family protein 0.0223 0.3005 0.3413
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Echinococcus multilocularis aldo keto reductase 0.0067 0.07 0.0617
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0067 0.07 0.0617
Trypanosoma brucei prostaglandin f synthase 0.0067 0.07 1
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0164 0.2344
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.3231 0.3171
Plasmodium falciparum heat shock protein 90 0.0033 0.0188 0.0624
Loa Loa (eye worm) hypothetical protein 0.0031 0.0164 0.0078
Onchocerca volvulus Huntingtin homolog 0.0123 0.1531 0.4169
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0031 0.0164 0.1234
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0164 0.2344
Brugia malayi heat shock protein 90 0.0033 0.0188 0.0097
Loa Loa (eye worm) hypothetical protein 0.0223 0.3005 0.3413
Loa Loa (eye worm) oxidoreductase 0.0067 0.07 0.0708
Schistosoma mansoni apoptosis regulator bax 0.0601 0.8616 0.8601
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0188 0.1615
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0067 0.07 1
Leishmania major aldo-keto reductase-like protein 0.0067 0.07 1
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0224 0.0716
Echinococcus multilocularis Polycystic kidney disease protein 0.0223 0.3005 0.2943
Mycobacterium leprae Isocitrate lyase 0.0235 0.3192 0.4397
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0422 0.0373
Schistosoma mansoni endoplasmin 0.0033 0.0188 0.0083
Loa Loa (eye worm) oxidoreductase 0.0067 0.07 0.0708
Echinococcus granulosus single minded 2 0.0089 0.1017 0.0937
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0224 0.2215
Echinococcus granulosus intermediate filament protein 0.0027 0.0105 0.0016
Mycobacterium tuberculosis Probable oxidoreductase 0.0067 0.07 0.0867
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0067 0.07 1
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0038 0.0263 0.5
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0067 0.07 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0224 0.3201
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0067 0.07 0.0617
Echinococcus granulosus lipoxygenase domain containing protein 0.0223 0.3005 0.2943
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0188 0.1615
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0188 0.1615
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0224 0.0149
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0067 0.07 0.07
Loa Loa (eye worm) endoplasmin 0.0033 0.0188 0.0106
Brugia malayi hypothetical protein 0.0123 0.1531 0.1675
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0624 0.895 0.8941
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0067 0.07 0.0867
Echinococcus granulosus heat shock protein 90 0.0033 0.0188 0.01
Loa Loa (eye worm) hypothetical protein 0.0123 0.1531 0.1682
Loa Loa (eye worm) hypothetical protein 0.0027 0.0105 0.0009
Echinococcus multilocularis geminin 0.0171 0.2231 0.2162
Echinococcus multilocularis transfer RNA-Lys 0.0089 0.1017 0.0937
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0224 0.3201
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Mycobacterium leprae Possible regulatory protein 0.0031 0.0164 0.0107
Mycobacterium ulcerans putative regulatory protein 0.0089 0.1017 0.1316
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0601 0.8616 0.8604
Schistosoma mansoni endoplasmin 0.0033 0.0188 0.0083
Leishmania major protein kinase, putative 0.0031 0.0164 0.1234
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.0089 0.5
Brugia malayi hypothetical protein 0.0238 0.3231 0.3673
Brugia malayi bHLH-PAS transcription factor 0.0089 0.1017 0.1072
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0089 0.1267
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0227 0.3063 0.3475
Mycobacterium ulcerans isocitrate lyase Icl 0.0502 0.7146 1
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0031 0.0164 0.2344
Giardia lamblia Aldose reductase 0.0067 0.07 1
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Loa Loa (eye worm) hypothetical protein 0.0228 0.3078 0.3499
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0105 0.0009
Schistosoma mansoni hypothetical protein 0.0601 0.8616 0.8601
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0067 0.07 0.0617
Onchocerca volvulus 0.0223 0.3005 0.8481
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0224 0.3201
Entamoeba histolytica hypothetical protein 0.0035 0.0224 0.0716
Echinococcus multilocularis lamin dm0 0.0027 0.0105 0.0016
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Schistosoma mansoni hypothetical protein 0.0049 0.0422 0.0321
Trichomonas vaginalis aldo/keto reductase, putative 0.0067 0.07 1
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0224 0.0716
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0031 0.0164 0.1234
Treponema pallidum heat shock protein 90 0.0026 0.0089 0.5
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0224 0.013
Onchocerca volvulus 0.0049 0.0422 0.0928
Brugia malayi hypothetical protein 0.0031 0.0164 0.007
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0031 0.0164 0.1234
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0601 0.8616 1
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Trypanosoma brucei aldo-keto reductase, putative 0.0067 0.07 1
Echinococcus granulosus Polycystic kidney disease protein 0.0223 0.3005 0.2943
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0089 0.1267
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0032 0.018 0.0096
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0067 0.07 0.0617
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Schistosoma mansoni survival motor neuron protein 0.0049 0.0422 0.0321
Leishmania major prostaglandin f synthase, putative 0.0067 0.07 1
Echinococcus granulosus hypothetical protein 0.0067 0.07 0.0617
Echinococcus multilocularis RUN 0.0223 0.3005 0.2943
Schistosoma mansoni microtubule-associated protein tau 0.0694 1 1
Schistosoma mansoni aldo-keto reductase 0.0067 0.07 0.0602
Echinococcus granulosus aldo keto reductase 0.0067 0.07 0.0617
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0067 0.07 0.07
Mycobacterium ulcerans isocitrate lyase AceAb 0.0502 0.7146 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0188 0.1615
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Schistosoma mansoni polycystin 1-related 0.0223 0.3005 0.2931
Schistosoma mansoni lipoxygenase 0.0223 0.3005 0.2931
Schistosoma mansoni lipoxygenase 0.0624 0.895 0.8939
Onchocerca volvulus 0.0067 0.07 0.1742
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Onchocerca volvulus 0.0223 0.3005 0.8481
Leishmania major basic transcription factor 3a, putative 0.0035 0.0224 0.2215
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0032 0.018 0.0092
Schistosoma mansoni rab6-interacting 0.0223 0.3005 0.2931
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0089 0.1267
Onchocerca volvulus 0.0067 0.07 0.1742
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0031 0.0164 0.2344
Brugia malayi Doublecortin family protein 0.0223 0.3005 0.3408
Loa Loa (eye worm) oxidoreductase 0.0067 0.07 0.0708
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0067 0.07 0.0617
Trichomonas vaginalis aldo/keto reductase, putative 0.0067 0.07 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0223 0.3005 0.2943
Echinococcus multilocularis aldo keto reductase 0.0067 0.07 0.0617
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0105 0.0009
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0031 0.0164 0.2344
Schistosoma mansoni hypothetical protein 0.0223 0.3005 0.2931
Echinococcus multilocularis heat shock protein 0.0033 0.0188 0.01
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0031 0.0164 0.1234
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0067 0.07 1
Onchocerca volvulus 0.0067 0.07 0.1742
Echinococcus granulosus heat shock protein 0.0033 0.0188 0.01
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0031 0.0164 0.1234
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0164 0.2344
Loa Loa (eye worm) hypothetical protein 0.0238 0.3231 0.3679
Entamoeba histolytica aldose reductase, putative 0.0067 0.07 1
Onchocerca volvulus 0.0258 0.3524 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.0502 0.7146 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0223 0.3005 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0067 0.07 0.07
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0188 0.0106
Schistosoma mansoni transcription factor btf3 0.0035 0.0224 0.0121
Echinococcus granulosus transcription factor btf3 0.0035 0.0224 0.0137
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0067 0.07 0.0617
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0188 0.2677
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0067 0.07 0.0617
Entamoeba histolytica aldose reductase, putative 0.0067 0.07 1
Echinococcus multilocularis heat shock protein 90 0.0033 0.0188 0.01
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Echinococcus multilocularis lipoxygenase domain containing protein 0.0223 0.3005 0.2943
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0188 0.1615
Schistosoma mansoni hypothetical protein 0.0601 0.8616 0.8601
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0224 0.2215
Entamoeba histolytica aldose reductase, putative 0.0067 0.07 1
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.3231 0.3171
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0031 0.0164 0.2344
Schistosoma mansoni single-minded 0.012 0.1479 0.1389
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.0502 0.7146 1
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0601 0.8616 0.8604
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Echinococcus granulosus geminin 0.0171 0.2231 0.2162
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Loa Loa (eye worm) hypothetical protein 0.0223 0.3005 0.3413
Echinococcus granulosus aldo keto reductase 0.0067 0.07 0.0617
Echinococcus multilocularis aldo keto reductase 0.0067 0.07 0.0617
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Brugia malayi hypothetical protein 0.0223 0.3005 0.3408
Schistosoma mansoni hypothetical protein 0.0601 0.8616 0.8601
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0067 0.07 0.0617
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0031 0.0164 0.1234
Brugia malayi beta-NAC-like protein 0.0035 0.0224 0.014
Schistosoma mansoni hypothetical protein 0.0171 0.2231 0.2149
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Schistosoma mansoni rab6-interacting 0.0223 0.3005 0.2931
Loa Loa (eye worm) hypothetical protein 0.0123 0.1531 0.1682
Loa Loa (eye worm) oxidoreductase 0.0067 0.07 0.0708
Loa Loa (eye worm) hypothetical protein 0.0601 0.8616 1
Echinococcus multilocularis transcription factor btf3 0.0035 0.0224 0.0137
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0601 0.8616 0.8604
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Loa Loa (eye worm) oxidoreductase 0.0067 0.07 0.0708
Loa Loa (eye worm) hypothetical protein 0.0067 0.07 0.0708
Onchocerca volvulus 0.009 0.1033 0.2713
Mycobacterium leprae Conserved hypothetical protein 0.0048 0.0411 0.0457
Schistosoma mansoni pol-related 0.0067 0.07 0.0602
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0031 0.0164 0.1234
Onchocerca volvulus 0.0067 0.07 0.1742
Brugia malayi PAS domain containing protein 0.012 0.1479 0.1615
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0032 0.018 0.0092
Schistosoma mansoni aryl hydrocarbon receptor 0.0347 0.4855 0.48
Echinococcus granulosus lipoxygenase domain containing protein 0.0223 0.3005 0.2943
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0067 0.07 0.0617
Mycobacterium ulcerans oxidoreductase 0.0067 0.07 0.0867
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0031 0.0164 0.2344
Trichomonas vaginalis adenylate cyclase, putative 0.0031 0.0164 0.2344
Schistosoma mansoni hypothetical protein 0.0171 0.2231 0.2149
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Echinococcus multilocularis lamin 0.0027 0.0105 0.0016
Echinococcus multilocularis aldehyde reductase 0.0048 0.0411 0.0326
Echinococcus granulosus lamin 0.0027 0.0105 0.0016
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0601 0.8616 0.8604
Trichomonas vaginalis aldo/keto reductase, putative 0.0067 0.07 1
Echinococcus multilocularis musashi 0.0027 0.0105 0.0016
Onchocerca volvulus 0.0067 0.07 0.1742
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Onchocerca volvulus 0.0067 0.07 0.1742
Echinococcus granulosus lamin dm0 0.0027 0.0105 0.0016
Trichomonas vaginalis aldo-keto reductase, putative 0.0067 0.07 1
Mycobacterium leprae PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) 0.0502 0.7146 1
Plasmodium falciparum LCCL domain-containing protein 0.0223 0.3005 1
Leishmania major heat shock protein 83-1 0.0033 0.0188 0.1615
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0067 0.07 1
Loa Loa (eye worm) apoptosis regulator protein 0.0601 0.8616 1
Toxoplasma gondii aldose reductase, putative 0.0067 0.07 1
Echinococcus multilocularis aryl hydrocarbon receptor 0.0259 0.354 0.3482
Echinococcus granulosus aryl hydrocarbon receptor 0.0259 0.354 0.3482
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0067 0.07 0.0617
Echinococcus multilocularis aldo keto reductase 0.0067 0.07 0.0617
Schistosoma mansoni heat shock protein 0.0033 0.0188 0.0083
Trypanosoma cruzi aldo-keto reductase 0.0067 0.07 1
Trichomonas vaginalis guanylate cyclase, putative 0.0031 0.0164 0.2344
Leishmania major protein kinase, putative 0.0031 0.0164 0.1234

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 58 uM Cytotoxicity against Homo sapiens (human) MCF7 cells after 24 hr by MTT assay ChEMBL. No reference
MIC (functional) = 16 ug ml-1 Antifungal activity against Cryptococcus neoformans clinical isolate after 48 hr by NCCLS two-fold serial dilution method ChEMBL. No reference
MIC (functional) = 16 ug ml-1 Antifungal activity against Candida albicans ATCC 2091 after 48 hr by NCCLS two-fold serial dilution method ChEMBL. No reference
MIC (functional) = 16 ug ml-1 Antibacterial activity against Escherichia coli ATCC 35218 after 24 hr by NCCLS two-fold serial dilution method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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