Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Spinacia oleracea | Cytochrome b6-f complex subunit 4 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0028 | 0.0389 | 0.5 |
Schistosoma mansoni | cytochrome b | 0.0076 | 0.4755 | 0.4543 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0028 | 0.0389 | 0.5 |
Plasmodium falciparum | cytochrome b | 0.0076 | 0.4755 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0034 | 0.0939 | 0.126 |
Loa Loa (eye worm) | cytochrome b | 0.0076 | 0.4755 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0389 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0034 | 0.0939 | 1 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0028 | 0.0389 | 0.4145 |
Schistosoma mansoni | cytochrome b | 0.0076 | 0.4755 | 0.4543 |
Echinococcus multilocularis | geminin | 0.0133 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0034 | 0.0939 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0028 | 0.0389 | 0.4145 |
Echinococcus multilocularis | dna polymerase eta | 0.0034 | 0.0939 | 0.0572 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0939 | 0.126 |
Echinococcus granulosus | dna polymerase eta | 0.0034 | 0.0939 | 0.0572 |
Plasmodium vivax | cytochrome b | 0.0076 | 0.4755 | 0.5 |
Brugia malayi | cytochrome b | 0.0076 | 0.4755 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0028 | 0.0389 | 0.4145 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0028 | 0.0389 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0034 | 0.0939 | 1 |
Toxoplasma gondii | apocytochrome b, putative | 0.0076 | 0.4755 | 1 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0076 | 0.4755 | 0.5 |
Toxoplasma gondii | cytochrome b | 0.0076 | 0.4755 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0028 | 0.0389 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0034 | 0.0939 | 0.0572 |
Echinococcus granulosus | cytochrome B | 0.0076 | 0.4755 | 0.4543 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.54 | Inhibition of photosynthetic electron transport in Spinacia oleracea leaf thylakoids assessed as oxygen formation | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.