Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Spinacia oleracea | Cytochrome b6-f complex subunit 4 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.0133 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0389 | 0.5 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0028 | 0.0389 | 0.4145 |
Schistosoma mansoni | cytochrome b | 0.0076 | 0.4755 | 0.4543 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0034 | 0.0939 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0034 | 0.0939 | 0.0572 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0034 | 0.0939 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0028 | 0.0389 | 0.4145 |
Plasmodium falciparum | cytochrome b | 0.0076 | 0.4755 | 0.5 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0028 | 0.0389 | 0.5 |
Schistosoma mansoni | cytochrome b | 0.0076 | 0.4755 | 0.4543 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0028 | 0.0389 | 0.5 |
Loa Loa (eye worm) | cytochrome b | 0.0076 | 0.4755 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0034 | 0.0939 | 0.126 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0076 | 0.4755 | 0.5 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0028 | 0.0389 | 0.5 |
Toxoplasma gondii | cytochrome b | 0.0076 | 0.4755 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0034 | 0.0939 | 1 |
Toxoplasma gondii | apocytochrome b, putative | 0.0076 | 0.4755 | 1 |
Echinococcus granulosus | cytochrome B | 0.0076 | 0.4755 | 0.4543 |
Schistosoma mansoni | DNA polymerase eta | 0.0034 | 0.0939 | 0.0572 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0939 | 0.126 |
Plasmodium vivax | cytochrome b | 0.0076 | 0.4755 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0034 | 0.0939 | 0.0572 |
Brugia malayi | cytochrome b | 0.0076 | 0.4755 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0028 | 0.0389 | 0.4145 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0028 | 0.0389 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.01 | Inhibition of photosynthetic electron transport in Spinacia oleracea leaf thylakoids assessed as oxygen formation | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.