Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0372 | 0.6976 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0213 | 0.2567 | 0.5 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0372 | 0.6976 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.012 | 0 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0318 | 0.5477 | 0.5 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0372 | 0.6976 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0213 | 0.2567 | 0.5 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.012 | 0 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase | 0.0213 | 0.2567 | 0.368 |
Mycobacterium ulcerans | hypothetical protein | 0.0372 | 0.6976 | 1 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0213 | 0.2567 | 0.368 |
Loa Loa (eye worm) | ILVBL protein | 0.0225 | 0.291 | 0.0449 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.012 | 0 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0372 | 0.6976 | 1 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.0481 | 0.9996 | 1 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0213 | 0.2567 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.8347 | 0.7777 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0213 | 0.2567 | 0.368 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0372 | 0.6976 | 0.5 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0372 | 0.6976 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.012 | 0 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0318 | 0.5477 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 15 mm | Antibacterial activity against Escherichia coli at 50 mg/well after 24 hr by agar well diffusion assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.