Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0353 | 0.1096 | 0.0811 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0262 | 0.075 | 0.075 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase small chain | 0.0146 | 0.031 | 0.031 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0956 | 0.3381 | 0.3169 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.2352 | 0.8678 | 1 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0183 | 0.045 | 0.045 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.0134 | 0.0134 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0146 | 0.031 | 0.0178 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.27 | 1 | 1 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain, putative | 0.0146 | 0.031 | 0.0178 |
Brugia malayi | Probable DNA topoisomerase II | 0.0216 | 0.0575 | 0.0575 |
Schistosoma mansoni | polycystin 1-related | 0.0262 | 0.075 | 0.075 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.018 | 0.0439 | 0.0133 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0049 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0216 | 0.0575 | 0.766 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0049 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.27 | 1 | 1 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0262 | 0.075 | 0.075 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0262 | 0.075 | 0.075 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0421 | 0.1353 | 0.1353 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0465 | 0.152 | 0.1407 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.018 | 0.0439 | 0.0309 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.27 | 1 | 1 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0146 | 0.031 | 0.0178 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0216 | 0.0575 | 0.0575 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.27 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0956 | 0.3381 | 0.367 |
Onchocerca volvulus | 0.0262 | 0.075 | 1 | |
Brugia malayi | Integrin beta pat-3 precursor | 0.0303 | 0.0906 | 0.0906 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0227 |
Brugia malayi | thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) | 0.0146 | 0.031 | 0.0149 |
Onchocerca volvulus | 0.0262 | 0.075 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0063 | 0.0063 |
Echinococcus multilocularis | thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0063 | 0.0063 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.2352 | 0.8678 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0262 | 0.075 | 0.0454 |
Echinococcus multilocularis | integrin beta 2 | 0.0225 | 0.0607 | 0.0607 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0353 | 0.1096 | 0.0811 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.018 | 0.0439 | 0.0309 |
Schistosoma mansoni | serine-type protease inhibitor | 0.0442 | 0.1432 | 0.1432 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0049 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0956 | 0.3381 | 0.3169 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0956 | 0.3381 | 0.3169 |
Loa Loa (eye worm) | integrin beta-2 | 0.0303 | 0.0906 | 0.0906 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0216 | 0.0575 | 0.766 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0465 | 0.152 | 0.1574 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0216 | 0.0575 | 0.0273 |
Schistosoma mansoni | lipoxygenase | 0.1097 | 0.3918 | 0.3918 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.0452 | 0.0452 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.27 | 1 | 1 |
Schistosoma mansoni | serine-type protease inhibitor | 0.0442 | 0.1432 | 0.1432 |
Chlamydia trachomatis | transcriptional repressor NrdR | 0.0348 | 0.1077 | 0.0958 |
Brugia malayi | ribonucleotide reductase 2 | 0.0146 | 0.031 | 0.031 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.27 | 1 | 1 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0183 | 0.045 | 0.045 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0216 | 0.0575 | 0.0575 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0956 | 0.3381 | 0.3293 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0216 | 0.0575 | 0.0273 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0097 | 0.0124 | 0.0124 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.27 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit beta | 0.0146 | 0.031 | 0.0181 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0262 | 0.075 | 0.075 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0146 | 0.031 | 0.0178 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0131 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0124 | 0.0124 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0159 | 0.0358 | 0.0049 |
Onchocerca volvulus | 0.0113 | 0.0183 | 0.2441 | |
Echinococcus multilocularis | RUN | 0.0262 | 0.075 | 0.075 |
Loa Loa (eye worm) | ribonucleotide reductase M2 B | 0.0146 | 0.031 | 0.031 |
Loa Loa (eye worm) | hypothetical protein | 0.0883 | 0.3106 | 0.3106 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0007 | 0.0007 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0066 | 0.0007 | 0.0007 |
Schistosoma mansoni | rab6-interacting | 0.0262 | 0.075 | 0.075 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0956 | 0.3381 | 0.3169 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.157 | 0.5711 | 0.5711 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0216 | 0.0575 | 1 |
Echinococcus granulosus | RUN | 0.0262 | 0.075 | 0.075 |
Echinococcus granulosus | integrin beta 2 | 0.0225 | 0.0607 | 0.0607 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0137 | 0.0276 | 0.0109 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0216 | 0.0575 | 0.0273 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0131 | 0.0131 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.007 | 0.002 | 0.002 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) | 0.0146 | 0.031 | 0.0149 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0465 | 0.152 | 0.1574 |
Giardia lamblia | DNA topoisomerase II | 0.02 | 0.0515 | 0.5 |
Leishmania major | DNA topoisomerase ii | 0.018 | 0.0439 | 0.0133 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0353 | 0.1096 | 0.0811 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.157 | 0.5711 | 0.5711 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.27 | 1 | 1 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.27 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.007 | 0.002 | 0.002 |
Mycobacterium leprae | conserved hypothetical protein | 0.0348 | 0.1077 | 0.1052 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0956 | 0.3381 | 0.3764 |
Schistosoma mansoni | DNA topoisomerase II | 0.0216 | 0.0575 | 0.0575 |
Mycobacterium tuberculosis | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) | 0.0845 | 0.2963 | 0.3272 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0216 | 0.0575 | 0.0575 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0097 | 0.0124 | 0.0124 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0465 | 0.152 | 0.1249 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.27 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.007 | 0.002 | 0.002 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0465 | 0.152 | 0.1446 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0183 | 0.045 | 0.045 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0097 | 0.0124 | 0.0124 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase subunit | 0.0146 | 0.031 | 0.031 |
Schistosoma mansoni | rab6-interacting | 0.0262 | 0.075 | 0.075 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0216 | 0.0575 | 0.0575 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0956 | 0.3381 | 0.3764 |
Mycobacterium ulcerans | transcriptional regulator NrdR | 0.0348 | 0.1077 | 0.1052 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.018 | 0.0439 | 0.0133 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0183 | 0.045 | 0.045 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0465 | 0.152 | 0.1249 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0254 | 0.0719 | 0.0422 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0465 | 0.152 | 0.1249 |
Brugia malayi | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Schistosoma mansoni | loxhd1 | 0.0262 | 0.075 | 0.075 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.2352 | 0.8678 | 1 |
Echinococcus multilocularis | Kelch repeat type 1 | 0.0184 | 0.0452 | 0.0452 |
Brugia malayi | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.002 | 0.002 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.27 | 1 | 1 |
Loa Loa (eye worm) | doublecortin family protein | 0.0262 | 0.075 | 0.075 |
Echinococcus granulosus | ribonucleoside diphosphate reductase subunit | 0.0146 | 0.031 | 0.031 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0353 | 0.1096 | 0.0974 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.007 | 0.002 | 0.002 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.2352 | 0.8678 | 1 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0183 | 0.045 | 0.045 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0007 | 0.0007 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0262 | 0.075 | 0.075 |
Loa Loa (eye worm) | hypothetical protein | 0.0883 | 0.3106 | 0.3106 |
Schistosoma mansoni | lipoxygenase | 0.157 | 0.5711 | 0.5711 |
Brugia malayi | Doublecortin family protein | 0.0262 | 0.075 | 0.075 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0721 | 0.2492 | 0.2252 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.27 | 1 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0328 | 0.0999 | 0.088 |
Loa Loa (eye worm) | thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0049 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0216 | 0.0575 | 0.0575 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0262 | 0.075 | 0.0454 |
Schistosoma mansoni | integrin beta subunit | 0.0179 | 0.0432 | 0.0432 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.2352 | 0.8678 | 1 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein NrdR | 0.0348 | 0.1077 | 0.1052 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0456 | 0.1483 | 0.153 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0216 | 0.0575 | 0.766 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0262 | 0.075 | 0.075 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 16.6 % |
Compound (50 mM) was tested in vitro for inhibitory potency against Fas-associated phosphatase- 1 binding from HFAP-10cDNA subcloned into the bluescript vector pSK-II(Stratagene) |
ChEMBL. | 10464015 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.