Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0073 | 0.5954 | 0.4771 |
Schistosoma mansoni | glutamate receptor kainate | 0.0084 | 0.7295 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.3046 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.005 | 0.3046 | 0.1012 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0051 | 0.3198 | 0.1209 |
Treponema pallidum | lysophosphatidic acid acyltransferase | 0.0073 | 0.5954 | 0.5 |
Echinococcus multilocularis | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0073 | 0.5954 | 0.4771 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0063 | 0.467 | 0.311 |
Toxoplasma gondii | acyltransferase domain-containing protein | 0.0073 | 0.5954 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.005 | 0.3046 | 0.3474 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0052 | 0.329 | 0.3753 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0105 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0094 | 0.8529 | 0.8098 |
Loa Loa (eye worm) | acyltransferase | 0.0073 | 0.5954 | 0.6792 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0094 | 0.8529 | 0.8098 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0063 | 0.467 | 0.311 |
Mycobacterium tuberculosis | 1-acylglycerol-3-phosphate O-acyltransferase | 0.0073 | 0.5954 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0105 | 1 | 1 |
Schistosoma mansoni | transcription factor | 0.007 | 0.5578 | 0.5958 |
Trypanosoma cruzi | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0073 | 0.5954 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.005 | 0.3046 | 0.1012 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0051 | 0.3198 | 0.1209 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0094 | 0.8529 | 0.8098 |
Toxoplasma gondii | acyltransferase domain-containing protein | 0.0073 | 0.5954 | 1 |
Chlamydia trachomatis | glycerol-3-phosphate acyltransferase | 0.0073 | 0.5954 | 0.5 |
Echinococcus multilocularis | NMDA receptor | 0.0051 | 0.3198 | 0.1209 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0094 | 0.8529 | 0.8098 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.5954 | 0.6792 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0094 | 0.8529 | 0.8098 |
Trypanosoma brucei | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0073 | 0.5954 | 1 |
Brugia malayi | Acyltransferase family protein | 0.0073 | 0.5954 | 0.6792 |
Echinococcus granulosus | glutamate receptor 2 | 0.0086 | 0.7593 | 0.689 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.3046 | 0.5 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0052 | 0.329 | 0.0575 |
Schistosoma mansoni | glutamate receptor kainate | 0.0052 | 0.329 | 0.0575 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0051 | 0.3198 | 0.1209 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2263 | 0.2582 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.005 | 0.3046 | 0.1012 |
Schistosoma mansoni | 1-acyl-sn-glycerol-3-phosphate o-acyltransferase | 0.0073 | 0.5954 | 0.6844 |
Wolbachia endosymbiont of Brugia malayi | 1-acyl-sn-glycerol-3-phosphate acyltransferase | 0.0073 | 0.5954 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0062 | 0.4524 | 0.3478 |
Echinococcus multilocularis | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0073 | 0.5954 | 0.4771 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2263 | 0.2582 |
Mycobacterium ulcerans | bifunctional transmembrane phospholipid biosynthesis enzyme PlsC | 0.0073 | 0.5954 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0094 | 0.8529 | 0.8098 |
Leishmania major | 1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative | 0.0073 | 0.5954 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0052 | 0.329 | 0.0575 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.5578 | 0.6362 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.3046 | 0.5 |
Echinococcus granulosus | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0073 | 0.5954 | 0.4771 |
Echinococcus multilocularis | Phospholipid glycerol acyltransferase | 0.0073 | 0.5954 | 0.4771 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.5954 | 0.6792 |
Echinococcus multilocularis | homeobox | 0.007 | 0.5578 | 0.4284 |
Schistosoma mansoni | glutamate receptor kainate | 0.0084 | 0.7295 | 1 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0096 | 0.8766 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.005 | 0.3046 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2263 | 0.2582 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0105 | 1 | 1 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0052 | 0.329 | 0.0575 |
Echinococcus granulosus | Phospholipid glycerol acyltransferase | 0.0073 | 0.5954 | 0.4771 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0096 | 0.8766 | 0.8405 |
Mycobacterium leprae | POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERI | 0.0073 | 0.5954 | 0.5 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0052 | 0.329 | 0.0575 |
Mycobacterium ulcerans | 1-acylglycerol-3-phosphate O-acyltransferase | 0.0073 | 0.5954 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.3046 | 0.5 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0096 | 0.8766 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0052 | 0.329 | 0.1327 |
Plasmodium vivax | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0073 | 0.5954 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0096 | 0.8766 | 1 |
Echinococcus granulosus | Msx-like | 0.007 | 0.5578 | 0.4284 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0051 | 0.3198 | 0.1209 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.005 | 0.3046 | 0.3474 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.005 | 0.3046 | 0.1012 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0086 | 0.7593 | 0.689 |
Plasmodium falciparum | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0073 | 0.5954 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0052 | 0.329 | 0.1327 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.