Detailed information for compound 1846855

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 324.203 | Formula: C9H14FN4O6P
  • H donors: 4 H acceptors: 4 LogP: -3.18 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1C[C@@H](O[C@@H]1COP(=O)(N)N)n1cc(F)c(=O)[nH]c1=O
  • InChi: 1S/C9H14FN4O6P/c10-4-2-14(9(17)13-8(4)16)7-1-5(15)6(20-7)3-19-21(11,12)18/h2,5-7,15H,1,3H2,(H4,11,12,18)(H,13,16,17)/t5-,6+,7+/m0/s1
  • InChiKey: ZNJDAYPNRYKSKB-RRKCRQDMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT 0.0195 0.0355 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0074 0.0092 0.0092
Onchocerca volvulus 0.0074 0.0092 0.0924
Echinococcus multilocularis neuropeptide Y receptor 0.0074 0.0092 0.0092
Onchocerca volvulus 0.0074 0.0092 0.0924
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.0092 0.0092
Trichomonas vaginalis ribose-phosphate pyrophosphokinase, putative 0.0046 0.0029 0.0116
Echinococcus multilocularis geminin 0.0329 0.0648 0.0648
Onchocerca volvulus 0.0074 0.0092 0.0924
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0195 0.0355 0.5453
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0046 0.0029 0.0394
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0006 0.0006
Schistosoma mansoni opsin-like receptor 0.0074 0.0092 0.1368
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.4603 1 1
Mycobacterium ulcerans hypothetical protein 0.0046 0.0029 0.0071
Brugia malayi hypothetical protein 0.0074 0.0092 0.0924
Echinococcus granulosus neuropeptide FF receptor 2 0.0074 0.0092 0.0092
Brugia malayi G-protein coupled receptor 0.0074 0.0092 0.0924
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0011 0.0198
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0006 0.0039
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Loa Loa (eye worm) TYRA-2 protein 0.0074 0.0092 0.0924
Echinococcus multilocularis neuropeptide FF receptor 2 0.0074 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Schistosoma mansoni histamine h1 receptor 0.0074 0.0092 0.1368
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0195 0.0355 0.5571
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0074 0.0092 0.0092
Echinococcus granulosus biogenic amine 5HT receptor 0.0074 0.0092 0.0092
Echinococcus granulosus uridine 5' monophosphate synthase 0.0046 0.0029 0.0029
Entamoeba histolytica hypothetical protein 0.0038 0.0013 1
Brugia malayi follicle stimulating hormone receptor 0.0074 0.0092 0.0924
Onchocerca volvulus 0.0035 0.0006 0.0026
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.017 0.0302 0.1277
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0076 0.0095 0.1421
Echinococcus granulosus adenine phosphoribosyltransferase 0.0046 0.0029 0.0029
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0011 0.0198
Onchocerca volvulus 0.0074 0.0092 0.0924
Loa Loa (eye worm) hypothetical protein 0.047 0.0958 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0092 0.1368
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.0092 0.0092
Mycobacterium leprae PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE) 0.0046 0.0029 0.0109
Onchocerca volvulus Neuropeptide F receptor homolog 0.0074 0.0092 0.0924
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0006 0.0039
Loa Loa (eye worm) neuropeptide F receptor 0.0074 0.0092 0.0924
Onchocerca volvulus 0.047 0.0958 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0074 0.0092 0.1368
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.017 0.0302 0.1277
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0092 0.0092
Echinococcus multilocularis voltage dependent calcium channel 0.0076 0.0095 0.0095
Mycobacterium leprae AMIDOPHOSPHORIBOSYLTRANSFERASE PURF (GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE) (ATASE) (GPATASE) 0.0046 0.0029 0.0109
Echinococcus multilocularis neuropeptides capa receptor 0.0074 0.0092 0.0092
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0092 0.0092
Schistosoma mansoni amine GPCR 0.0074 0.0092 0.1368
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0092 0.1368
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0046 0.0031 0.0757
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0006 0.0011
Schistosoma mansoni transcription factor btf3 0.0037 0.0011 0.0108
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Echinococcus granulosus neuropeptide Y receptor 0.0074 0.0092 0.0092
Plasmodium falciparum orotate phosphoribosyltransferase 0.0046 0.0029 0.0723
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0046 0.0029 0.0394
Onchocerca volvulus 0.0074 0.0092 0.0924
Treponema pallidum hypothetical protein 0.017 0.0302 0.0729
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0013 0.0144
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Loa Loa (eye worm) hypothetical protein 0.0035 0.0006 0.0026
Treponema pallidum penicillin-binding protein (pbp-1) 0.19 0.4087 1
Brugia malayi neuropeptide F receptor 0.0074 0.0092 0.0924
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0034 0.0004 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0092 0.0092
Onchocerca volvulus 0.0074 0.0092 0.0924
Loa Loa (eye worm) glutaminase 0.0265 0.051 0.5302
Echinococcus multilocularis neuropeptides capa receptor 0.0074 0.0092 0.0092
Echinococcus granulosus neuropeptide receptor 0.0074 0.0092 0.0092
Trichomonas vaginalis Ribose-phosphate pyrophosphokinase, putative 0.0046 0.0029 0.0116
Echinococcus granulosus orexin receptor type 2 0.0074 0.0092 0.0092
Echinococcus granulosus allatostatin A receptor 0.0074 0.0092 0.0092
Brugia malayi Melatonin receptor type 1A 0.0074 0.0092 0.0924
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0006 0.0071
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0074 0.0092 0.0924
Echinococcus granulosus biogenic amine 5HT receptor 0.0074 0.0092 0.0092
Mycobacterium tuberculosis Conserved protein 0.0035 0.0006 0.0011
Treponema pallidum phosphoribosylpyrophosphate synthetase 0.0046 0.0029 0.0062
Schistosoma mansoni alpha-1 adrenergic receptor 0.0074 0.0092 0.1368
Loa Loa (eye worm) glutaminase 2 0.0265 0.051 0.5302
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0076 0.0095 0.0959
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0074 0.0092 0.0092
Schistosoma mansoni neuropeptide receptor 0.0074 0.0092 0.1368
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Wolbachia endosymbiont of Brugia malayi orotate phosphoribosyltransferase 0.0046 0.0029 0.0062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0092 0.1368
Echinococcus granulosus neuropeptide receptor A26 0.0074 0.0092 0.0092
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0074 0.0092 0.1368
Echinococcus multilocularis neuropeptide receptor 0.0074 0.0092 0.0092
Echinococcus granulosus zinc phosphodiesterase 0.0034 0.0004 0.0004
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0046 0.0029 0.0723
Schistosoma mansoni adenoreceptor 0.0074 0.0092 0.1368
Loa Loa (eye worm) hypothetical protein 0.0035 0.0006 0.0026
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0898 0.1893 0.8103
Schistosoma mansoni glutaminase 0.0265 0.051 0.7853
Brugia malayi hypothetical protein 0.0074 0.0092 0.0924
Loa Loa (eye worm) melatonin receptor type 1A 0.0074 0.0092 0.0924
Schistosoma mansoni biogenic amine receptor 0.0074 0.0092 0.1368
Brugia malayi beta-NAC-like protein 0.0037 0.0011 0.0073
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Loa Loa (eye worm) hypothetical protein 0.047 0.0958 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.0092 0.1368
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0006 0.0011
Echinococcus granulosus somatostatin receptor 0.0074 0.0092 0.0092
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0074 0.0092 0.1368
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0011 0.0198
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0011 0.0073
Brugia malayi ORL1-like opioid receptor 0.0074 0.0092 0.0924
Echinococcus granulosus g protein coupled receptor 0.0074 0.0092 0.0092
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0074 0.0092 0.0924
Onchocerca volvulus 0.0195 0.0355 0.3681
Onchocerca volvulus 0.0035 0.0006 0.0026
Brugia malayi RE15519p 0.0074 0.0092 0.0924
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.1031 0.2185 0.6105
Echinococcus granulosus neuropeptide Y receptor 0.0074 0.0092 0.0092
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0006 0.0011
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0006 0.0039
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0006 0.0011
Entamoeba histolytica hypothetical protein 0.0038 0.0013 1
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0046 0.0029 0.0723
Echinococcus granulosus neuropeptides capa receptor 0.0074 0.0092 0.0092
Mycobacterium tuberculosis Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase) 0.0046 0.0029 0.0109
Echinococcus multilocularis g protein coupled receptor 0.0074 0.0092 0.0092
Schistosoma mansoni biogenic amine receptor 0.0074 0.0092 0.1368
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0074 0.0092 0.0924
Echinococcus granulosus serotonin receptor 0.0074 0.0092 0.0092
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0046 0.0029 0.0723
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0074 0.0092 0.0924
Schistosoma mansoni hypothetical protein 0.0329 0.0648 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0074 0.0092 0.1368
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0061 0.0594
Brugia malayi Tachykinin-like peptides receptor 99D 0.0074 0.0092 0.0924
Giardia lamblia Guanine phosphoribosyltransferase 0.0195 0.0355 1
Brugia malayi hypothetical protein 0.0074 0.0092 0.0924
Echinococcus granulosus neuropeptide receptor 0.0074 0.0092 0.0092
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0074 0.0092 0.0092
Onchocerca volvulus 0.0074 0.0092 0.0924
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0195 0.0355 1
Echinococcus multilocularis serotonin receptor 0.0074 0.0092 0.0092
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0705 0.1471 0.4107
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0034 0.0004 0.0004
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0374 0.3877
Mycobacterium ulcerans bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 0.0046 0.0029 0.0071
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0195 0.0355 1
Brugia malayi hypothetical protein 0.013 0.0214 0.2202
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0426 0.0861 0.3675
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0092 0.1368
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0195 0.0355 0.0355
Trichomonas vaginalis set domain proteins, putative 0.0231 0.0435 0.1978
Echinococcus multilocularis uridine 5' monophosphate synthase 0.0046 0.0029 0.0029
Echinococcus multilocularis neuropeptide receptor A26 0.0074 0.0092 0.0092
Leishmania major hypothetical protein, conserved 0.0035 0.0006 0.0071
Schistosoma mansoni myosin xvIII 0.0074 0.0092 0.1368
Brugia malayi jmjC domain containing protein 0.006 0.0061 0.0594
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0092 0.1368
Brugia malayi larval opioid receptor 0.0074 0.0092 0.0924
Loa Loa (eye worm) hypothetical protein 0.0035 0.0006 0.0026
Brugia malayi G protein-coupled receptor F59B2.13 0.0074 0.0092 0.0924
Echinococcus granulosus 7tm_1 domain containing protein 0.0074 0.0092 0.0092
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.11 0.2335 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Mycobacterium ulcerans hypoxanthine-guanine phosphoribosyltransferase Hpt 0.0195 0.0355 0.0983
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0074 0.0092 0.0924
Echinococcus multilocularis somatostatin receptor 0.0074 0.0092 0.0092
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0034 0.0004 0.0004
Schistosoma mansoni neuropeptide receptor 0.0074 0.0092 0.1368
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.017 0.0302 0.0834
Schistosoma mansoni hypothetical protein 0.0074 0.0092 0.1368
Echinococcus multilocularis allatostatin A receptor 0.0074 0.0092 0.0092
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0195 0.0355 0.0355
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0195 0.0355 0.0355
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0074 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Schistosoma mansoni neuropeptide F-like receptor 0.0074 0.0092 0.1368
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Schistosoma mansoni opsin-like receptor 0.0074 0.0092 0.1368
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0076 0.0095 0.0095
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0195 0.0355 0.0355
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0074 0.0092 0.0092
Entamoeba histolytica hypothetical protein 0.0038 0.0013 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase, putative 0.0195 0.0355 0.5571
Brugia malayi hypothetical protein 0.0038 0.0013 0.0097
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Echinococcus granulosus neuropeptide s receptor 0.0074 0.0092 0.0092
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0011 0.011
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0074 0.0092 0.0092
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0076 0.0095 0.0095
Brugia malayi Pre-SET motif family protein 0.0203 0.0374 0.3877
Brugia malayi hypothetical protein 0.0074 0.0092 0.0924
Echinococcus multilocularis transcription factor btf3 0.0037 0.0011 0.0011
Loa Loa (eye worm) beta-lactamase 0.0035 0.0006 0.0026
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0046 0.0029 0.0394
Echinococcus multilocularis ETHE1 protein 0.0034 0.0004 0.0004
Onchocerca volvulus 0.0074 0.0092 0.0924
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0074 0.0092 0.0092
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0006 0.0011
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0074 0.0092 0.0092
Onchocerca volvulus 0.0035 0.0006 0.0026
Mycobacterium tuberculosis Conserved protein 0.0046 0.0029 0.0109
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Echinococcus multilocularis g protein coupled receptor 0.0074 0.0092 0.0092
Onchocerca volvulus 0.0074 0.0092 0.0924
Treponema pallidum penicillin-binding protein (pbp-3) 0.1837 0.3949 0.9662
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0898 0.1893 0.8103
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.0092 0.0092
Mycobacterium ulcerans orotate phosphoribosyltransferase 0.0046 0.0029 0.0071
Brugia malayi GnHR receptor homolog 0.0074 0.0092 0.0924
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0006 0.0011
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0046 0.0029 0.0394
Schistosoma mansoni hypothetical protein 0.0074 0.0092 0.1368
Mycobacterium tuberculosis Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase) 0.0046 0.0029 0.0109
Leishmania major hypoxanthine-guanine phosphoribosyltransferase 0.0195 0.0355 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0006 0.0071
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0046 0.0031 0.0422
Echinococcus granulosus dro:myosuppressin receptor 0.0074 0.0092 0.0092
Mycobacterium tuberculosis Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor 0.0149 0.0256 0.108
Echinococcus granulosus sex peptide receptor 0.0074 0.0092 0.0092
Brugia malayi beta-lactamase 0.0035 0.0006 0.0026
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0322 0.0635 0.2705
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0046 0.0029 0.0723
Schistosoma mansoni lozenge 0.0059 0.0059 0.085
Echinococcus multilocularis voltage dependent calcium channel 0.0076 0.0095 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0092 0.1368
Echinococcus multilocularis G-protein coupled receptor, putative 0.0074 0.0092 0.0092
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0074 0.0092 0.0924
Brugia malayi putative neuropeptide receptor 0.0074 0.0092 0.0924
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase 0.0195 0.0355 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.0006 0.0007
Schistosoma mansoni amine GPCR 0.0074 0.0092 0.1368
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0092 0.1368
Leishmania major adenine phosphoribosyltransferase 0.0046 0.0029 0.0723
Brugia malayi beta-lactamase family protein 0.0035 0.0006 0.0026
Mycobacterium ulcerans adenine phosphoribosyltransferase 0.0046 0.0029 0.0071
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0195 0.0355 0.5571
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.1667 0.3577 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0092 0.0092
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0705 0.1471 0.6294
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0092 0.0092
Mycobacterium ulcerans glutaminase 0.0265 0.051 0.1416
Mycobacterium tuberculosis Conserved protein 0.0046 0.0029 0.0109
Echinococcus multilocularis neuropeptide s receptor 0.0074 0.0092 0.0092
Schistosoma mansoni amine GPCR 0.0074 0.0092 0.1368
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Mycobacterium tuberculosis Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase) 0.0046 0.0029 0.0109
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0074 0.0092 0.0092
Echinococcus granulosus geminin 0.0329 0.0648 0.0648
Echinococcus multilocularis Protein lozenge 0.0059 0.0059 0.0059
Onchocerca volvulus 0.0074 0.0092 0.0924
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0061 0.088
Loa Loa (eye worm) G-protein coupled receptor 0.0074 0.0092 0.0924
Brugia malayi G protein-coupled receptor 0.0074 0.0092 0.0924
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0092 0.0092
Schistosoma mansoni amine GPCR 0.0074 0.0092 0.1368
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0322 0.0635 0.2705
Brugia malayi G-protein coupled receptor 0.0074 0.0092 0.0924
Schistosoma mansoni neuropeptide F-like receptor 0.0074 0.0092 0.1368
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0011 0.0032
Onchocerca volvulus 0.0074 0.0092 0.0924
Echinococcus multilocularis neuropeptide Y receptor 0.0074 0.0092 0.0092
Mycobacterium leprae Probable lipase LipE 0.0035 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0671 0.1398 0.5981
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0074 0.0092 0.0092
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.0092 0.1368
Onchocerca volvulus 0.0074 0.0092 0.0924
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0034 0.0004 0.0004
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0671 0.1398 0.3903
Brugia malayi hypothetical protein 0.047 0.0958 1
Loa Loa (eye worm) orotate phosphoribosyltransferase 0.0046 0.0029 0.0266
Schistosoma mansoni growth hormone secretagogue receptor 0.0074 0.0092 0.1368
Leishmania major xanthine phosphoribosyltransferase 0.0195 0.0355 1
Leishmania major orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative 0.0046 0.0029 0.0723
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0195 0.0355 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0074 0.0092 0.1368
Treponema pallidum hypothetical protein 0.0046 0.0029 0.0062
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Echinococcus multilocularis fmrfamide receptor 0.0074 0.0092 0.0092
Trypanosoma brucei beta lactamase 0.0322 0.0635 1
Echinococcus granulosus fmrfamide receptor 0.0074 0.0092 0.0092
Schistosoma mansoni jumonji domain containing protein 0.006 0.0061 0.088
Loa Loa (eye worm) hypothetical protein 0.0035 0.0006 0.0026
Echinococcus multilocularis orexin receptor type 2 0.0074 0.0092 0.0092
Treponema pallidum adenine phosphoribosyltransferase 0.0046 0.0029 0.0062
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Echinococcus granulosus g protein coupled receptor 0.0074 0.0092 0.0092
Schistosoma mansoni voltage-gated cation channel 0.0076 0.0095 0.1421
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0046 0.0029 0.0723
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0705 0.1471 0.6294
Mycobacterium ulcerans penicillin-binding protein PbpA 0.11 0.2335 0.6526
Onchocerca volvulus 0.0231 0.0435 0.452
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0006 0.0011
Loa Loa (eye worm) calcium channel 0.0076 0.0095 0.0959
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0074 0.0092 0.0924
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0006 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0006 0.0071
Brugia malayi Serotonin receptor 0.0074 0.0092 0.0924
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.042 0.1784
Echinococcus multilocularis zinc phosphodiesterase 0.0034 0.0004 0.0004
Schistosoma mansoni uracil phosphoribosyltransferase 0.0046 0.0029 0.0394
Brugia malayi Phosphoribosyl transferase domain containing protein 0.0195 0.0355 0.3681
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0303 0.0594 0.2529
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0011 0.0198
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0061 0.0061
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0195 0.0355 0.5453
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0074 0.0092 0.1368
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0074 0.0092 0.0924
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.1031 0.2185 0.9355
Brugia malayi neuropeptide F receptor 0.0074 0.0092 0.0924
Loa Loa (eye worm) hypothetical protein 0.0339 0.0671 0.6988
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0074 0.0092 0.0092
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0076 0.0095 0.0095
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0074 0.0092 0.0924
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0074 0.0092 0.0092
Schistosoma mansoni neuropeptide f receptor 76f 0.0074 0.0092 0.1368
Mycobacterium ulcerans hypothetical protein 0.0035 0.0006 0.0007
Brugia malayi beta-lactamase family protein 0.0035 0.0006 0.0026
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0046 0.0029 0.0403
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.19 0.4087 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0074 0.0092 0.1368
Plasmodium vivax orotate phosphoribosyltransferase, putative 0.0046 0.0029 0.0723
Brugia malayi Dopamine receptor protein 1 0.0074 0.0092 0.0924
Schistosoma mansoni hypothetical protein 0.0038 0.0013 0.0144
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0076 0.0095 0.0959
Brugia malayi putative neuropeptide receptor NPR1 0.0074 0.0092 0.0924
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0006 0.0011
Echinococcus multilocularis dro:myosuppressin receptor 0.0074 0.0092 0.0092
Brugia malayi jmjC domain containing protein 0.006 0.0061 0.0594
Loa Loa (eye worm) hypothetical protein 0.0035 0.0006 0.0026
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Leishmania major basic transcription factor 3a, putative 0.0037 0.0011 0.0198
Loa Loa (eye worm) runx1 0.0059 0.0059 0.0574
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0011 0.0198
Onchocerca volvulus 0.0074 0.0092 0.0924
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.0092 0.1368
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.11 0.2335 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0074 0.0092 0.1368
Loa Loa (eye worm) neuropeptide F receptor 0.0074 0.0092 0.0924
Brugia malayi hypothetical protein 0.0074 0.0092 0.0924
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0195 0.0355 1
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0046 0.0029 0.0403
Echinococcus multilocularis g-protein coupled receptor 0.0074 0.0092 0.0092
Schistosoma mansoni neuropeptide receptor 0.0074 0.0092 0.1368
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0061 0.0061
Brugia malayi glutaminase DH11.1 0.0265 0.051 0.5302
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0046 0.0029 0.0723
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0011 0.0032
Treponema pallidum penicillin-binding protein (pbp-2) 0.1031 0.2185 0.5342
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0074 0.0092 0.0092
Schistosoma mansoni orotidine 5'-phosphate decarboxylase 0.0046 0.0029 0.0394
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0061 0.088
Trypanosoma brucei orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0046 0.0029 0.0403
Loa Loa (eye worm) adenine phosphoribosyltransferase 0.0046 0.0029 0.0266
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0076 0.0095 0.0095
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0426 0.0861 0.3675
Brugia malayi hypothetical protein 0.0074 0.0092 0.0924
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0006 0.0007
Mycobacterium tuberculosis Conserved protein 0.0035 0.0006 0.0011
Brugia malayi hypothetical protein 0.0074 0.0092 0.0924
Trichomonas vaginalis esterase, putative 0.0035 0.0006 0.0011
Echinococcus granulosus g protein coupled receptor 0.0074 0.0092 0.0092
Onchocerca volvulus 0.0074 0.0092 0.0924
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0074 0.0092 0.0924
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0076 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0898 0.1893 0.5288
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0074 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Entamoeba histolytica hypothetical protein 0.0037 0.0011 0.7467
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Brugia malayi Dopamine receptor 0.0074 0.0092 0.0924
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0013 0.0013
Mycobacterium ulcerans amidophosphoribosyltransferase 0.0046 0.0029 0.0071
Trichomonas vaginalis glutaminase, putative 0.0265 0.051 0.232
Schistosoma mansoni biogenic amine (5HT) receptor 0.0074 0.0092 0.1368
Brugia malayi hypothetical protein 0.0074 0.0092 0.0924
Echinococcus granulosus G protein coupled receptor 139 0.0074 0.0092 0.0092
Echinococcus granulosus voltage dependent calcium channel 0.0076 0.0095 0.0095
Echinococcus multilocularis fmrfamide receptor 0.0074 0.0092 0.0092
Brugia malayi AKH receptor 0.0074 0.0092 0.0924
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0006 0.0011
Schistosoma mansoni neuropeptide receptor 0.0074 0.0092 0.1368
Echinococcus granulosus transcription factor btf3 0.0037 0.0011 0.0011
Schistosoma mansoni biogenic amine (5HT) receptor 0.0074 0.0092 0.1368
Echinococcus multilocularis serotonin receptor 0.0074 0.0092 0.0092
Mycobacterium tuberculosis Conserved hypothetical protein 0.0046 0.0029 0.0109
Mycobacterium leprae Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho 0.0149 0.0256 0.108
Onchocerca volvulus 0.0074 0.0092 0.0924
Onchocerca volvulus Adenine phosphoribosyltransferase homolog 0.0046 0.0029 0.0266
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0092 0.1368
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0076 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Echinococcus multilocularis adenine phosphoribosyltransferase 0.0046 0.0029 0.0029
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0061 0.0061
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0074 0.0092 0.0092
Schistosoma mansoni opsin-like receptor 0.0074 0.0092 0.1368
Entamoeba histolytica hypothetical protein 0.0038 0.0013 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0074 0.0092 0.0092
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0013 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0092 0.0092
Brugia malayi Dopamine receptor protein 2 0.0074 0.0092 0.0924
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0006 0.0011
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0076 0.0095 0.1421
Echinococcus multilocularis G protein coupled receptor 139 0.0074 0.0092 0.0092
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0092 0.0092
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0006 0.0006
Mycobacterium ulcerans lipase LipD 0.0035 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Trichomonas vaginalis conserved hypothetical protein 0.1031 0.2185 1
Brugia malayi sulfakinin receptor protein 0.0074 0.0092 0.0924
Loa Loa (eye worm) hypothetical protein 0.0035 0.0006 0.0026
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0011 0.7467
Echinococcus granulosus hypothetical protein 0.0074 0.0092 0.0092
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0034 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Loa Loa (eye worm) G-protein coupled receptor 0.0074 0.0092 0.0924
Toxoplasma gondii orotate phosphoribosyltransferase 0.0046 0.0029 0.0723
Echinococcus multilocularis g protein coupled receptor 0.0074 0.0092 0.0092
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0074 0.0092 0.1368
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0074 0.0092 0.1368
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0011 0.0032
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Echinococcus granulosus 7TM GPCR rhodopsin 0.0074 0.0092 0.0092
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0061 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.0092 0.1368
Echinococcus granulosus neuropeptides capa receptor 0.0074 0.0092 0.0092
Mycobacterium tuberculosis Conserved protein 0.0035 0.0006 0.0011
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase, putative 0.0195 0.0355 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0074 0.0092 0.0924
Schistosoma mansoni hypothetical protein 0.0329 0.0648 1
Mycobacterium tuberculosis Probable pyrimidine operon regulatory protein PyrR 0.0046 0.0029 0.0109
Toxoplasma gondii ABC1 family protein 0.0035 0.0006 0.0071
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0092 0.0092
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0092 0.0092
Chlamydia trachomatis transglycolase/transpeptidase 0.0866 0.1825 0.446
Echinococcus granulosus g-protein coupled receptor 0.0074 0.0092 0.0092
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0092 0.0092
Brugia malayi hypothetical protein 0.0074 0.0092 0.0924
Giardia lamblia Adenine phosphoribosyltransferase 0.0046 0.0029 0.0723
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0006 0.0007
Trichomonas vaginalis hypoxanthine-guanine phosphoribosyltransferase, putative 0.0195 0.0355 0.1611
Echinococcus granulosus peptide allatostatin:somatostatin 0.0074 0.0092 0.0092
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.0092 0.0092
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0034 0.0004 0.0004
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0076 0.0095 0.0095
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.0092 0.0092
Wolbachia endosymbiont of Brugia malayi amidophosphoribosyltransferase 0.0046 0.0029 0.0062
Schistosoma mansoni hypothetical protein 0.0074 0.0092 0.1368
Echinococcus granulosus alpha 1A adrenergic receptor 0.0074 0.0092 0.0092
Brugia malayi orotate phosphoribosyltransferase family protein 0.0046 0.0029 0.0266
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0006 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0092 0.0092
Brugia malayi Serotonin receptor 0.0074 0.0092 0.0924
Schistosoma mansoni hypothetical protein 0.0074 0.0092 0.1368
Onchocerca volvulus 0.0074 0.0092 0.0924
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0006 0.0026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Echinococcus multilocularis neuropeptide receptor 0.0074 0.0092 0.0092
Schistosoma mansoni amine GPCR 0.0074 0.0092 0.1368
Mycobacterium ulcerans lipoprotein LpqF 0.0322 0.0635 0.1765
Brugia malayi Adenine phosphoribosyltransferase 0.0046 0.0029 0.0266
Echinococcus granulosus ETHE1 protein 0.0034 0.0004 0.0004
Echinococcus multilocularis sex peptide receptor 0.0074 0.0092 0.0092
Brugia malayi hypothetical protein 0.0074 0.0092 0.0924
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0074 0.0092 0.0092
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0006 0.0011
Schistosoma mansoni biogenic amine receptor 0.0074 0.0092 0.1368
Onchocerca volvulus 0.0074 0.0092 0.0924
Loa Loa (eye worm) hypothetical protein 0.0074 0.0092 0.0924
Chlamydia trachomatis transglycolase/transpeptidase 0.19 0.4087 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 2 nM Comparative inhibition of L5178Y cell growth in vitro (concentration required for 50% inhibition) ChEMBL. 6779007
Inhibition (binding) Compound was tested for its inhibition against Thymidylate synthase up to concentration of 1 mM; IA means inactive ChEMBL. 6779007
Inhibition (functional) = 45 % In vitro percent inhibition at 10 e-8 M against L5178Y cell growth after 72 h (replicate flasks inoculated with 10 e5 cells were treated with the nucleotide) ChEMBL. 6779007

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 6779007

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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