TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 788.647 | Formula: C31H41N4O18P
H donors: 11 H acceptors: 17 LogP: -0.18 Rotable bonds: 28
Rule of 5 violations (Lipinski): 4
SMILES: CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)O)CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)/C(=C/c1ccc(cc1)OP(=O)(O)O)/C(=O)O)CCC(=O)O)CCC(=O)O)C
InChi: 1S/C31H41N4O18P/c1-3-15(2)25(29(45)34-21(31(48)49)10-13-24(40)41)35-28(44)20(9-12-23(38)39)33-27(43)19(8-11-22(36)37)32-26(42)18(30(46)47)14-16-4-6-17(7-5-16)53-54(50,51)52/h4-7,14-15,19-21,25H,3,8-13H2,1-2H3,(H,32,42)(H,33,43)(H,34,45)(H,35,44)(H,36,37)(H,38,39)(H,40,41)(H,46,47)(H,48,49)(H2,50,51,52)/b18-14-/t15-,19-,20-,21-,25-/m0/s1
InChiKey: VCECFZLMMSNCAF-XCPKKTTBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0051	0.0213	0.0344
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0064	0.0282	0.3015
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0045	0.018	0.1855
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0048	0.0196	0.0316
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0036	0.0113
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0036	0.006
Brugia malayi	AMP-binding enzyme family protein	0.0015	0.0009	0.0007
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0045	0.0179	0.0291
Brugia malayi	Doublecortin family protein	0.0022	0.0049	0.017
Schistosoma mansoni	loxhd1	0.0022	0.0049	0.0253
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0039	0.0144	0.0156
Trichomonas vaginalis	set domain proteins, putative	0.0506	0.275	0.5944
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0045	0.018	0.1855
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.018	0.1855
Brugia malayi	hypothetical protein	0.0022	0.0049	0.017
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0029	0.0186
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0048	0.0196	0.0217
Mycobacterium leprae	POSSIBLE PENICILLIN-BINDING LIPOPROTEIN	0.0332	0.1776	0.3008
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0064	0.0282	0.1704
Schistosoma mansoni	rab6-interacting	0.0022	0.0049	0.0253
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0036	0.022
Chlamydia trachomatis	transglycolase/transpeptidase	0.0823	0.4512	0.44
Mycobacterium ulcerans	fatty acid synthase Fas	0.0015	0.0011	0.0002
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0041	0.0155	0.1576
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0035	0.012	0.0192
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	0.002	0.0036	0.0047
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0325	0.1736	0.3747
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0174	0.0899	0.5531
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.2346
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0119	0.043
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0045	0.018	0.1855
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.018	0.1855
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0036	0.0116
Schistosoma mansoni	glutaminase	0.0304	0.1619	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0041	0.0155	0.1576
Trypanosoma brucei	DNA polymerase IV, putative	0.0038	0.014	0.1764
Giardia lamblia	DINP protein human, muc B family	0.0023	0.0057	0.0284
Toxoplasma gondii	type I fatty acid synthase, putative	0.0034	0.0119	0.3367
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0142	0.0718	1
Leishmania major	phosphopantetheinyl transferase-like protein	0.0049	0.02	0.2706
Loa Loa (eye worm)	glutaminase 2	0.0304	0.1619	0.6704
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0036	0.0277
Echinococcus granulosus	transcription factor Dp 1	0.0082	0.0385	0.4174
Plasmodium vivax	multidomain scavenger receptor, putative	0.0022	0.0049	0.1369
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.004	0.0147	0.0237
Onchocerca volvulus		0.0022	0.0049	0.0176
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0142	0.0718	1
Entamoeba histolytica	hypothetical protein	0.0049	0.02	0.1069
Loa Loa (eye worm)	fatty acid synthase	0.0048	0.0193	0.0739
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0142	0.0718	0.795
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0036	0.0277
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0049	0.02	0.0221
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0036	0.006
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0049	0.02	0.6665
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.0057	0.0692
Echinococcus granulosus	dna polymerase kappa	0.0046	0.0181	0.1865
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0142	0.0718	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0036	0.0081
Brugia malayi	SRC-1	0.0045	0.018	0.0717
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.2346
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0046	0.0181	0.0375
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0049	0.02	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0029	0.0186
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0024	0.0063	0.1108
Treponema pallidum	penicillin-binding protein (pbp-1)	0.1807	1	1
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0142	0.0718	0.296
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0046	0.0181	0.2346
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.018	0.1855
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0064	0.0282	0.1704
Mycobacterium tuberculosis	Possible penicillin-binding lipoprotein	0.0332	0.1776	0.3012
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0041	0.0155	0.1576
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0039	0.0144	0.0156
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0159	0.0811	0.1362
Mycobacterium tuberculosis	Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase	0.0262	0.139	0.2354
Treponema pallidum	penicillin-binding protein (pbp-3)	0.1562	0.8633	0.8628
Echinococcus granulosus	histone lysine methyltransferase setb	0.0064	0.0282	0.3015
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0159	0.0811	0.0929
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.2346
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0045	0.018	0.1855
Mycobacterium ulcerans	penicillin-binding membrane protein PbpB	0.1562	0.8633	1
Mycobacterium leprae	PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE	0.0842	0.4621	0.7856
Loa Loa (eye worm)	acyl carrier protein	0.0022	0.0051	0.0144
Onchocerca volvulus		0.0174	0.0899	0.3269
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0045	0.0179	0.068
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0282	0.1113
Plasmodium vivax	SET domain protein, putative	0.0064	0.0282	1
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0048	0.0196	0.0217
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.2346
Loa Loa (eye worm)	hypothetical protein	0.0081	0.038	0.1522
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0131	0.0657	0.7256
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0072	0.033	0.0549
Mycobacterium tuberculosis	Probable penicillin-binding membrane protein PbpB	0.0491	0.2663	0.4522
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.004	0.0151	0.0239
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0325	0.1736	0.3747
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0142	0.0718	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.2346
Mycobacterium tuberculosis	Probable thioesterase TesA	0.004	0.0151	0.0245
Echinococcus granulosus	lipoxygenase domain containing protein	0.0022	0.0049	0.0368
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0325	0.1736	0.3747
Trypanosoma brucei	DNA polymerase kappa, putative	0.0035	0.0119	0.1465
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.2346
Brugia malayi	glutaminase DH11.1	0.0304	0.1619	0.6716
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0028	0.008	0.0123
Mycobacterium ulcerans	DNA polymerase IV	0.0046	0.0181	0.0199
Onchocerca volvulus		0.0045	0.0179	0.065
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsI	0.1807	1	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.0325	0.1736	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0046	0.0181	0.2346
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0016	0.0016	0.0014
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0029	0.0186
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0057	0.0582
Echinococcus multilocularis	dna polymerase kappa	0.0046	0.0181	0.1865
Loa Loa (eye worm)	SRC-1	0.0045	0.018	0.0685
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.2346
Loa Loa (eye worm)	hypothetical protein	0.0174	0.0899	0.3693
Echinococcus granulosus	tyrosine kinase	0.0041	0.0155	0.1576
Mycobacterium ulcerans	thioesterase TesA	0.004	0.0151	0.0165
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.0032	0.0105	0.0111
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0123	0.0614	0.1033
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0036	0.0047
Mycobacterium ulcerans	polyketide synthase Pks9	0.0032	0.0105	0.0111
Leishmania major	DNA polymerase eta, putative	0.0016	0.0016	0.0117
Mycobacterium tuberculosis	Polyketide synthetase MbtD (polyketide synthase)	0.0015	0.0009	0.0003
Mycobacterium ulcerans	penicillin-binding protein PbpA	0.1068	0.588	0.6807
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0123	0.0614	0.3765
Trypanosoma brucei	DNA polymerase IV, putative	0.0046	0.0181	0.2346
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0136
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0123	0.0614	0.2528
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0061	0.0269	0.2867
Mycobacterium tuberculosis	Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen	0.058	0.3158	0.5365
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0031	0.0102	0.2676
Loa Loa (eye worm)	doublecortin family protein	0.0022	0.0049	0.0136
Mycobacterium tuberculosis	Polyketide synthetase MbtC (polyketide synthase)	0.0017	0.0019	0.002
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0142	0.0718	0.2936
Brugia malayi	protein-tyrosine kinase	0.0041	0.0155	0.0614
Schistosoma mansoni	lipoxygenase	0.0092	0.0437	0.2664
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0325	0.1736	0.3747
Mycobacterium ulcerans	polyketide synthase	0.0051	0.0213	0.0236
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0036	0.0391
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0325	0.1736	0.3747
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0092	0.0438	0.1793
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0036	0.0889
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0049	0.0136
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0123	0.0614	0.6776
Brugia malayi	hypothetical protein	0.0022	0.0049	0.017
Schistosoma mansoni	rab6-interacting	0.0022	0.0049	0.0253
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	0.0032	0.0105	0.016
Loa Loa (eye worm)	glutaminase	0.0304	0.1619	0.6704
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0048	0.0196	0.0321
Trypanosoma brucei	unspecified product	0.0038	0.014	0.1764
Mycobacterium ulcerans	bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2	0.058	0.3158	0.3651
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0115	0.0568	0.2309
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0049	0.02	0.0165
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0045	0.018	0.1855
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0049	0.02	0.0165
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0047	0.0188	0.0307
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0325	0.1736	1
Brugia malayi	AMP-binding enzyme family protein	0.0045	0.0179	0.0712
Schistosoma mansoni	tyrosine kinase	0.0045	0.018	0.1068
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0142	0.0718	0.4408
Leishmania major	DNA polymerase kappa, putative	0.0023	0.0057	0.0692
Onchocerca volvulus		0.0084	0.0396	0.1441
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0045	0.018	0.1855
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0036	0.0161
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0036	0.022
Trypanosoma brucei	DNA polymerase IV, putative	0.0046	0.0181	0.2346
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0051	0.0213	0.0344
Schistosoma mansoni	tyrosine kinase	0.0045	0.018	0.1068
Mycobacterium leprae	conserved hypothetical protein	0.0049	0.02	0.0322
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0064	0.0282	1
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0123	0.0614	0.6776
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.018	0.1855
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0045	0.018	0.1855
Mycobacterium ulcerans	bifunctional penicillin-binding protein 1A/1B PonA1	0.0842	0.4621	0.5348
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0048	0.0196	0.0217
Schistosoma mansoni	hypothetical protein	0.0022	0.0049	0.0253
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0047	0.0188	0.0307
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0051	0.0213	0.0236
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0057	0.0084
Mycobacterium ulcerans	penicillin-binding lipoprotein	0.0332	0.1776	0.2049
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0048	0.0196	0.0786
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0123	0.0614	0.0702
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0174	0.0899	0.3715
Schistosoma mansoni	ap endonuclease	0.002	0.0036	0.0172
Echinococcus granulosus	RUN	0.0022	0.0049	0.0368
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.018	0.1855
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0142	0.0718	0.4081
Treponema pallidum	penicillin-binding protein (pbp-2)	0.0842	0.4621	0.4602
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0045	0.018	0.1855
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0049	0.02	0.0221
Toxoplasma gondii	type I fatty acid synthase, putative	0.0051	0.0213	0.7198
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0142	0.0718	0.795
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0123	0.0614	0.0702
Trichomonas vaginalis	conserved hypothetical protein	0.0842	0.4621	1
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0049	0.02	0.0327
Schistosoma mansoni	polycystin 1-related	0.0022	0.0049	0.0253
Mycobacterium ulcerans	polyketide synthase Pks13	0.0072	0.033	0.0372
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0445	0.2408	1
Brugia malayi	Pre-SET motif family protein	0.0064	0.0282	0.1144
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0325	0.1736	0.3747
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0325	0.1736	0.3747
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0051	0.0213	0.0344
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0039	0.0144	0.0226
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0174	0.0899	1
Onchocerca volvulus	Fatty acid synthase homolog	0.0087	0.0413	0.1502
Onchocerca volvulus		0.0506	0.275	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0046	0.0181	0.2346
Mycobacterium ulcerans	polyketide synthase	0.0048	0.0196	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0078	0.0258
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.2346
Echinococcus multilocularis	RUN	0.0022	0.0049	0.0368
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0022	0.0049	0.0368
Echinococcus multilocularis	Polycystic kidney disease protein	0.0022	0.0049	0.0368
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0048	0.0196	0.0321
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0049	0.02	0.6665
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0022	0.0049	0.0368
Schistosoma mansoni	lipoxygenase	0.0131	0.0657	0.4028
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0048	0.0196	0.0321
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0036	0.003
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0045	0.018	0.1855
Brugia malayi	ImpB/MucB/SamB family protein	0.0016	0.0016	0.0035
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0036	0.1277
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0041	0.0155	0.1576
Mycobacterium leprae	Polyketide synthase Pks13	0.0072	0.033	0.0543
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0051	0.0213	0.0236
Trypanosoma brucei	hypothetical protein, conserved	0.0049	0.02	0.262
Mycobacterium leprae	Probable penicillin-binding protein PbpA	0.1068	0.588	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0036	0.0277
Mycobacterium leprae	Probable penicillin-binding membrane protein PbpB	0.0491	0.2663	0.4518
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0051	0.0213	0.035
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.004	0.0148	0.1495
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0045	0.018	0.1855
Mycobacterium ulcerans	glutaminase	0.0304	0.1619	0.1867
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0049	0.02	0.6962
Mycobacterium ulcerans	DNA polymerase IV	0.0046	0.0181	0.0199
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0046	0.0181	0.2346
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0045	0.018	0.1855
Echinococcus granulosus	tyrosine protein kinase Src42A	0.004	0.0148	0.1495
Echinococcus granulosus	tyrosine protein kinase HCK	0.0036	0.013	0.1289
Trypanosoma brucei	DNA polymerase kappa, putative	0.0046	0.0181	0.2346
Trypanosoma brucei	DNA polymerase kappa, putative	0.0035	0.0119	0.1465
Schistosoma mansoni	ap endonuclease	0.002	0.0036	0.0172
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0016	0.0016	0.0052
Trichomonas vaginalis	DNA polymerase eta, putative	0.0046	0.0181	0.0375
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0036	0.013	0.1289
Echinococcus granulosus	Polycystic kidney disease protein	0.0022	0.0049	0.0368
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0051	0.0213	0.035
Echinococcus granulosus	lipoxygenase domain containing protein	0.0022	0.0049	0.0368
Onchocerca volvulus		0.0022	0.0049	0.0176
Brugia malayi	polk-prov protein	0.0035	0.0119	0.0463
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0072	0.033	0.0549
Treponema pallidum	fructose-bisphosphate aldolase	0.0325	0.1736	0.1707
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0064	0.0282	0.1704
Brugia malayi	ImpB/MucB/SamB family protein	0.0016	0.0016	0.0035
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0325	0.1736	1
Mycobacterium leprae	PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN	0.058	0.3158	0.5363
Loa Loa (eye worm)	TK protein kinase	0.0041	0.0155	0.0582
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0048	0.0196	0.0217
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0131	0.0657	0.7256
Schistosoma mansoni	DNA polymerase eta	0.0016	0.0016	0.0052
Entamoeba histolytica	protein kinase, putative	0.0036	0.013	0.0661
Echinococcus multilocularis	transcription factor Dp 1	0.0082	0.0385	0.4174
Trichomonas vaginalis	glutaminase, putative	0.0304	0.1619	0.3493
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0051	0.0213	0.035
Echinococcus granulosus	L aminoadipate semialdehyde	0.0174	0.0899	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0064	0.0282	0.3015
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0048	0.0196	0.0316
Loa Loa (eye worm)	TK protein kinase	0.0036	0.013	0.0476
Mycobacterium tuberculosis	Probable fatty acid synthase Fas (fatty acid synthetase)	0.0015	0.0011	0.0006
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0064	0.0282	0.1704
Echinococcus granulosus	tyrosine protein kinase Blk	0.0041	0.0155	0.1576
Mycobacterium ulcerans	thioesterase	0.004	0.0151	0.0165
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0159	0.0811	0.1367
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0016	0.0016	0.0052
Onchocerca volvulus		0.0064	0.0282	0.1026
Mycobacterium tuberculosis	Probable penicillin-binding protein PbpA	0.1068	0.588	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.018	0.1855
Brugia malayi	Pre-SET motif family protein	0.0445	0.2408	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0325	0.1736	0.3747
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0123	0.0614	0.854
Plasmodium falciparum	LCCL domain-containing protein	0.0022	0.0049	0.1967

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5 uM	Binding affinity to p60 src SH2 domain.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3143155

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1847777