Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | alpha glucosidase | 0.0224 | 0.5 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0224 | 0.5 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0224 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas | 0.0224 | 0.5 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0224 | 0.5 | 0.5 |
Mycobacterium ulcerans | trehalose synthase TreS | 0.0224 | 0.5 | 0.5 |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0224 | 0.5 | 0.5 |
Echinococcus multilocularis | alpha glucosidase | 0.0224 | 0.5 | 0.5 |
Mycobacterium leprae | Putative uncharacterized protein ML2045 | 0.0224 | 0.5 | 0.5 |
Loa Loa (eye worm) | alpha amylase | 0.0224 | 0.5 | 0.5 |
Loa Loa (eye worm) | alpha amylase | 0.0224 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Trehalose synthase TreS | 0.0224 | 0.5 | 0.5 |
Entamoeba histolytica | oligo-1,6-glucosidase, putative | 0.0224 | 0.5 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0224 | 0.5 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0224 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1000 uM | Inhibitory concentration against cytosolic thymidine kinase (TK-1) | ChEMBL. | 11392548 |
IC50 (binding) | > 1000 uM | Inhibitory concentration against mitochondrial thymidine kinase (TK-2) | ChEMBL. | 11392548 |
IC50 (binding) | > 1000 uM | Inhibitory concentration against Herpes simplex virus type 1 thymidine kinase(HSV-1 TK) | ChEMBL. | 11392548 |
IC50 (binding) | > 1000 uM | Inhibitory concentration against Varicella- zoster virus thymidine kinase(VZV TK) | ChEMBL. | 11392548 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.