Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Probable DNA topoisomerase II | 0.0216 | 0.0575 | 0.0575 |
Schistosoma mansoni | polycystin 1-related | 0.0262 | 0.075 | 0.075 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.018 | 0.0439 | 0.0133 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0049 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0216 | 0.0575 | 0.766 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0146 | 0.031 | 0.0178 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.27 | 1 | 1 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain, putative | 0.0146 | 0.031 | 0.0178 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0183 | 0.045 | 0.045 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.0134 | 0.0134 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.2352 | 0.8678 | 1 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0956 | 0.3381 | 0.3169 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0262 | 0.075 | 0.075 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase small chain | 0.0146 | 0.031 | 0.031 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0353 | 0.1096 | 0.0811 |
Echinococcus granulosus | thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Onchocerca volvulus | 0.0262 | 0.075 | 1 | |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0146 | 0.031 | 0.0178 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0216 | 0.0575 | 0.0575 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.27 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0956 | 0.3381 | 0.367 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.27 | 1 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0465 | 0.152 | 0.1407 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.018 | 0.0439 | 0.0309 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0421 | 0.1353 | 0.1353 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0262 | 0.075 | 0.075 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0262 | 0.075 | 0.075 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.27 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0049 |
Schistosoma mansoni | lipoxygenase | 0.1097 | 0.3918 | 0.3918 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0216 | 0.0575 | 0.0273 |
Loa Loa (eye worm) | integrin beta-2 | 0.0303 | 0.0906 | 0.0906 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0216 | 0.0575 | 0.766 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0465 | 0.152 | 0.1574 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.018 | 0.0439 | 0.0309 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0049 |
Schistosoma mansoni | serine-type protease inhibitor | 0.0442 | 0.1432 | 0.1432 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0956 | 0.3381 | 0.3169 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0956 | 0.3381 | 0.3169 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0063 | 0.0063 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.2352 | 0.8678 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0262 | 0.075 | 0.0454 |
Echinococcus multilocularis | integrin beta 2 | 0.0225 | 0.0607 | 0.0607 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0353 | 0.1096 | 0.0811 |
Onchocerca volvulus | 0.0262 | 0.075 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0063 | 0.0063 |
Echinococcus multilocularis | thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0303 | 0.0906 | 0.0906 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0227 |
Brugia malayi | thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) | 0.0146 | 0.031 | 0.0149 |
Loa Loa (eye worm) | ribonucleotide reductase M2 B | 0.0146 | 0.031 | 0.031 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0159 | 0.0358 | 0.0049 |
Onchocerca volvulus | 0.0113 | 0.0183 | 0.2441 | |
Echinococcus multilocularis | RUN | 0.0262 | 0.075 | 0.075 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0131 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0124 | 0.0124 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit beta | 0.0146 | 0.031 | 0.0181 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0262 | 0.075 | 0.075 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0146 | 0.031 | 0.0178 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0956 | 0.3381 | 0.3293 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0216 | 0.0575 | 0.0273 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0097 | 0.0124 | 0.0124 |
Schistosoma mansoni | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.27 | 1 | 1 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0183 | 0.045 | 0.045 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0216 | 0.0575 | 0.0575 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.0452 | 0.0452 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.27 | 1 | 1 |
Schistosoma mansoni | serine-type protease inhibitor | 0.0442 | 0.1432 | 0.1432 |
Chlamydia trachomatis | transcriptional repressor NrdR | 0.0348 | 0.1077 | 0.0958 |
Brugia malayi | ribonucleotide reductase 2 | 0.0146 | 0.031 | 0.031 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.27 | 1 | 1 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.27 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.007 | 0.002 | 0.002 |
Mycobacterium leprae | conserved hypothetical protein | 0.0348 | 0.1077 | 0.1052 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.157 | 0.5711 | 0.5711 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.27 | 1 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.02 | 0.0515 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0353 | 0.1096 | 0.0811 |
Leishmania major | DNA topoisomerase ii | 0.018 | 0.0439 | 0.0133 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) | 0.0146 | 0.031 | 0.0149 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.007 | 0.002 | 0.002 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0465 | 0.152 | 0.1574 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0216 | 0.0575 | 0.0273 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0137 | 0.0276 | 0.0109 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0131 | 0.0131 |
Schistosoma mansoni | rab6-interacting | 0.0262 | 0.075 | 0.075 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0956 | 0.3381 | 0.3169 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.157 | 0.5711 | 0.5711 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0216 | 0.0575 | 1 |
Echinococcus granulosus | RUN | 0.0262 | 0.075 | 0.075 |
Echinococcus granulosus | integrin beta 2 | 0.0225 | 0.0607 | 0.0607 |
Loa Loa (eye worm) | hypothetical protein | 0.0883 | 0.3106 | 0.3106 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0007 | 0.0007 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0066 | 0.0007 | 0.0007 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0097 | 0.0124 | 0.0124 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0183 | 0.045 | 0.045 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0465 | 0.152 | 0.1446 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.27 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.007 | 0.002 | 0.002 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0465 | 0.152 | 0.1249 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0216 | 0.0575 | 0.0575 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0097 | 0.0124 | 0.0124 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0956 | 0.3381 | 0.3764 |
Schistosoma mansoni | DNA topoisomerase II | 0.0216 | 0.0575 | 0.0575 |
Mycobacterium tuberculosis | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) | 0.0845 | 0.2963 | 0.3272 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.007 | 0.002 | 0.002 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.2352 | 0.8678 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0353 | 0.1096 | 0.0974 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.002 | 0.002 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.27 | 1 | 1 |
Loa Loa (eye worm) | doublecortin family protein | 0.0262 | 0.075 | 0.075 |
Echinococcus granulosus | ribonucleoside diphosphate reductase subunit | 0.0146 | 0.031 | 0.031 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.2352 | 0.8678 | 1 |
Brugia malayi | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Echinococcus multilocularis | Kelch repeat type 1 | 0.0184 | 0.0452 | 0.0452 |
Brugia malayi | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Schistosoma mansoni | loxhd1 | 0.0262 | 0.075 | 0.075 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0254 | 0.0719 | 0.0422 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0465 | 0.152 | 0.1249 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0465 | 0.152 | 0.1249 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase subunit | 0.0146 | 0.031 | 0.031 |
Schistosoma mansoni | rab6-interacting | 0.0262 | 0.075 | 0.075 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0216 | 0.0575 | 0.0575 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0956 | 0.3381 | 0.3764 |
Mycobacterium ulcerans | transcriptional regulator NrdR | 0.0348 | 0.1077 | 0.1052 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0183 | 0.045 | 0.045 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.018 | 0.0439 | 0.0133 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0262 | 0.075 | 0.075 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0216 | 0.0575 | 0.766 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.2352 | 0.8678 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0456 | 0.1483 | 0.153 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein NrdR | 0.0348 | 0.1077 | 0.1052 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Schistosoma mansoni | integrin beta subunit | 0.0179 | 0.0432 | 0.0432 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0262 | 0.075 | 0.0454 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0216 | 0.0575 | 0.0575 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0721 | 0.2492 | 0.2252 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0328 | 0.0999 | 0.088 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.27 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0049 |
Schistosoma mansoni | lipoxygenase | 0.157 | 0.5711 | 0.5711 |
Brugia malayi | Doublecortin family protein | 0.0262 | 0.075 | 0.075 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0183 | 0.045 | 0.045 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0007 | 0.0007 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0262 | 0.075 | 0.075 |
Loa Loa (eye worm) | hypothetical protein | 0.0883 | 0.3106 | 0.3106 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 10.1 % |
Compound (50 mM) was tested in vitro for inhibitory potency against Fas-associated phosphatase- 1 binding from HFAP-10cDNA subcloned into the bluescript vector pSK-II(Stratagene) |
ChEMBL. | 10464015 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.