Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0025 | 0.0457 | 0.0603 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0025 | 0.0457 | 1 |
Leishmania major | leucyl-tRNA synthetase, putative | 0.0025 | 0.0457 | 0.0603 |
Plasmodium vivax | hypothetical protein, conserved | 0.0025 | 0.0457 | 0.0603 |
Giardia lamblia | Leucyl-tRNA synthetase | 0.0025 | 0.0457 | 0.0603 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0025 | 0.0457 | 0.5 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0066 | 0.3754 | 1 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0066 | 0.3754 | 1 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0025 | 0.0457 | 0.0603 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0866 | 0.1769 |
Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 0.3754 | 0.3754 |
Brugia malayi | hypothetical protein | 0.003 | 0.0866 | 0.0866 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0066 | 0.3754 | 1 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0066 | 0.3754 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Brugia malayi | protein ZK524.3 | 0.0025 | 0.0457 | 0.0457 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.1769 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0066 | 0.3754 | 0.3597 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0025 | 0.0457 | 0.0603 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0025 | 0.0457 | 0.0603 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0457 | 0.0217 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0866 | 0.1769 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0866 | 0.0636 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0246 | 0.0246 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0025 | 0.0457 | 0.0603 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0866 | 0.1769 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0066 | 0.3754 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.1769 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0066 | 0.3754 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0457 | 0.0217 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0066 | 0.3754 | 1 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 0.3754 | 1 |
Toxoplasma gondii | tRNA ligases class I (M) protein | 0.0025 | 0.0457 | 0.0603 |
Brugia malayi | methionyl-tRNA synthetase | 0.0025 | 0.0457 | 0.0457 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0066 | 0.3754 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0866 | 0.1769 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0066 | 0.3754 | 1 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0066 | 0.3754 | 1 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0066 | 0.3754 | 1 |
Onchocerca volvulus | 0.0041 | 0.1719 | 0.5 | |
Treponema pallidum | leucyl-tRNA synthetase | 0.0025 | 0.0457 | 1 |
Plasmodium falciparum | methionine--tRNA ligase, putative | 0.0025 | 0.0457 | 0.0603 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0457 | 0.0217 |
Mycobacterium ulcerans | leucyl-tRNA synthetase | 0.0025 | 0.0457 | 0.0603 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0866 | 0.1769 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0025 | 0.0457 | 1 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0025 | 0.0457 | 0.5 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0066 | 0.3754 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.1769 |
Loa Loa (eye worm) | tyrosyl-tRNA synthetase | 0.0041 | 0.1719 | 0.151 |
Wolbachia endosymbiont of Brugia malayi | leucyl-tRNA synthetase | 0.0025 | 0.0457 | 0.0603 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0025 | 0.0457 | 0.0603 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0066 | 0.3754 | 1 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0066 | 0.3754 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.