Detailed information for compound 1868327

Basic information

Technical information
  • TDR Targets ID: 1868327
  • Name: 3,3-dimethylbut-1-ene
  • MW: 84.1595 | Formula: C6H12
  • H donors: 0 H acceptors: 0 LogP: 2.74 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CC(C)(C)C
  • InChi: 1S/C6H12/c1-5-6(2,3)4/h5H,1H2,2-4H3
  • InChiKey: PKXHXOTZMFCXSH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 558-37-2
  • 11069-54-8
  • EINECS 209-195-9
  • NSC 74119
  • 1-Butene, 3,3-dimethyl-
  • 2,2-Dimethyl-3-butene
  • 3,3-Dimethyl-1-butene
  • 3,3-Dimethylbutene
  • NSC74119
  • Neohexene
  • Trimethylvinylmethane
  • tert-Butylethene
  • tert-Butylethylene
  • tert-Hexene
  • InChI=1/C6H12/c1-5-6(2,3)4/h5H,1H2,2-4H
  • 119059_ALDRICH
  • 39832_FLUKA
  • 39833_FLUKA
  • SB 01051

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0043 0.089 0.0748
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0427 0.0278
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0043 0.089 0.1596
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0045 0.0984 0.0844
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0427 0.0288
Brugia malayi conserved hypotetical protein 0.0021 0.0153 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0045 0.0984 0.0984
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.9356 0.9802
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0984 0.0984
Onchocerca volvulus 0.0045 0.0984 0.1134
Schistosoma mansoni aldehyde dehydrogenase 0.0203 0.6453 0.6398
Schistosoma mansoni steroid hormone receptor ad4bp 0.0045 0.0984 0.0844
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.1413 0.1347
Loa Loa (eye worm) hypothetical protein 0.0043 0.089 0.0748
Onchocerca volvulus 0.0029 0.0427 0.0374
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.039 0.0253
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0242 0.0242
Brugia malayi nuclear hormone receptor 0.0021 0.0153 0.0153
Brugia malayi follicle stimulating hormone receptor 0.0259 0.8401 0.8401
Leishmania major hypothetical protein, conserved 0.022 0.7042 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1968 0.1753
Onchocerca volvulus 0.009 0.2542 0.3262
Echinococcus multilocularis ornithine aminotransferase 0.0024 0.0249 0.0102
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0427 0.0278
Loa Loa (eye worm) hypothetical protein 0.0045 0.0984 0.0844
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.1968 0.1843
Trypanosoma brucei carbonic anhydrase-like protein 0.0122 0.3653 0.4491
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0153 0.0153
Brugia malayi Common central domain of tyrosinase family protein 0.009 0.2542 0.2542
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0984 0.0888
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.1413 0.1279
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.4586 0.4502
Brugia malayi Pre-SET motif family protein 0.0029 0.0427 0.0427
Mycobacterium ulcerans aldehyde dehydrogenase 0.0203 0.6453 0.6363
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.2542 0.2542
Treponema pallidum fructose-bisphosphate aldolase 0.0286 0.9356 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0045 0.0984 0.1134
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0043 0.089 0.0788
Brugia malayi Ribonuclease 2-5A family protein 0.029 0.9505 0.9505
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0984 0.0984
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1968 0.1753
Onchocerca volvulus 0.0232 0.7475 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0122 0.3653 0.3554
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0028 0.0378 0.0378
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.9356 0.9339
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0043 0.089 0.0658
Echinococcus granulosus nuclear factor of activated T cells 5 0.0082 0.2264 0.2257
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0427 0.0293
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.4555 0.4416
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0043 0.089 0.0748
Loa Loa (eye worm) hypothetical protein 0.0045 0.0984 0.0844
Leishmania major carbonic anhydrase-like protein 0.0122 0.3653 0.4491
Mycobacterium ulcerans L-lysine aminotransferase 0.027 0.8804 0.8774
Echinococcus multilocularis carbonic anhydrase 0.0028 0.0378 0.0241
Brugia malayi hypothetical protein 0.0021 0.0153 0.0153
Echinococcus multilocularis thyroid hormone receptor alpha 0.0177 0.5553 0.5774
Entamoeba histolytica protein kinase, putative 0.029 0.9505 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0984 0.0844
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0045 0.0984 0.0844
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0045 0.0984 0.0984
Loa Loa (eye worm) hypothetical protein 0.0052 0.1221 0.1084
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0082 0.2264 0.2257
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0119 0.3538 0.3619
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.1413 0.1279
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0984 0.0888
Brugia malayi hypothetical protein 0.0024 0.0242 0.0242
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.398 0.4093
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0122 0.3653 0.4491
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.1221 0.1084
Echinococcus multilocularis serine:threonine protein kinase:endoribonuclease 0.029 0.9505 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0984 0.0984
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0045 0.0984 0.1134
Loa Loa (eye worm) IRE protein kinase 0.029 0.9505 0.9497
Echinococcus granulosus Aminotransferase class III 0.0024 0.0249 0.0102
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0045 0.0984 0.0888
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0122 0.3653 0.3653
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.1413 0.1347
Loa Loa (eye worm) hypothetical protein 0.0045 0.0984 0.0844
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0045 0.0984 0.0844
Echinococcus multilocularis carbonic anhydrase 0.0028 0.0378 0.0241
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0028 0.0378 0.0378
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0028 0.0378 0.0378
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.1968 0.1753
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.009 0.2542 0.2542
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.9356 0.9339
Loa Loa (eye worm) hypothetical protein 0.0024 0.0242 0.009
Giardia lamblia Fructose-bisphosphate aldolase 0.0286 0.9356 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0045 0.0984 0.0888
Schistosoma mansoni thyroid hormone receptor 0.0177 0.5553 0.5483
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0648 0.0648
Loa Loa (eye worm) hypothetical protein 0.009 0.2542 0.2426
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.1413 0.1347
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.027 0.8804 0.8804
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.027 0.8804 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0043 0.089 0.075
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0045 0.0984 0.0844
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0024 0.0249 0.5
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0242 0.009
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0024 0.0249 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0045 0.0984 0.0844
Echinococcus granulosus serine:threonine protein kinase:endoribonuclease 0.029 0.9505 1
Onchocerca volvulus 0.009 0.2542 0.3262
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.1413 0.1347
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.1221 0.1221
Loa Loa (eye worm) hypothetical protein 0.0028 0.0378 0.0229
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0045 0.0984 0.0888
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0028 0.0378 0.0378
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0045 0.0984 0.0844
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0122 0.3653 0.3554
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0892 0.079
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0259 0.8401 0.8377
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.9356 0.9339
Loa Loa (eye worm) carbonic anhydrase 3 0.0122 0.3653 0.3554
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.2542 0.2542
Echinococcus multilocularis carbonic anhydrase II 0.0122 0.3653 0.3743
Brugia malayi ShTK domain containing protein 0.009 0.2542 0.2542
Loa Loa (eye worm) hypothetical protein 0.0045 0.0984 0.0844
Loa Loa (eye worm) ShTK domain-containing protein 0.009 0.2542 0.2426
Brugia malayi nuclear hormone receptor 0.0045 0.0984 0.0984
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0242 0.0095
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.022 0.7042 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0427 0.0278
Brugia malayi nuclear receptor NHR-88 0.0045 0.0984 0.0984
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0892 0.079
Entamoeba histolytica protein kinase, putative 0.029 0.9505 1
Loa Loa (eye worm) glutaminase 0.0305 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0045 0.0984 0.0984
Schistosoma mansoni retinoic acid receptor RXR 0.0143 0.4368 0.4281
Schistosoma mansoni RAR-like nuclear receptor 0.0045 0.0984 0.0844
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.1968 0.1941
Echinococcus granulosus ornithine aminotransferase 0.0024 0.0249 0.0102
Schistosoma mansoni thyroid hormone receptor 0.0177 0.5553 0.5483
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0984 0.0844
Mycobacterium ulcerans aldehyde dehydrogenase 0.0203 0.6453 0.6363
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0984 0.0984
Mycobacterium ulcerans glutaminase 0.0305 1 1
Schistosoma mansoni coup transcription factor 0.0045 0.0984 0.0844
Brugia malayi nuclear receptor RXR 0.0021 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0028 0.0378 0.0229
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0984 0.0888
Echinococcus granulosus carbonic anhydrase 0.0028 0.0378 0.0241
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0203 0.6453 0.7252
Brugia malayi photoreceptor-specific nuclear receptor 0.0045 0.0984 0.0984
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0043 0.089 0.0658
Loa Loa (eye worm) ShTK domain-containing protein 0.009 0.2542 0.2426
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0122 0.3653 0.3653
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0028 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0024 0.0242 0.009
Brugia malayi nuclear hormone receptor family member odr-7 0.0021 0.0153 0.0153
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.1968 0.1968
Loa Loa (eye worm) tyrosinase 1 0.009 0.2542 0.2426
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0242 0.0095
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.9356 0.9802
Trichomonas vaginalis set domain proteins, putative 0.0232 0.7471 0.7406
Schistosoma mansoni tyrosinase precursor 0.009 0.2542 0.2426
Brugia malayi hypothetical protein 0.0021 0.0153 0.0153
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.1968 0.1843
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0153 0.0153
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.6492 0.6438
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0203 0.6453 0.6737
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0043 0.089 0.0658
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0043 0.089 0.0788
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0984 0.0984
Brugia malayi ecdysteroid receptor 0.0045 0.0984 0.0984
Brugia malayi Steroid receptor seven-up type 2 0.0045 0.0984 0.0984
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0122 0.3653 0.4491
Trichomonas vaginalis glutaminase, putative 0.0305 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0045 0.0984 0.0888
Loa Loa (eye worm) hypothetical protein 0.0028 0.0378 0.0229
Loa Loa (eye worm) hypothetical protein 0.0024 0.0242 0.009
Schistosoma mansoni hypothetical protein 0.0028 0.0378 0.0229
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0122 0.3653 0.3554
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.022 0.7042 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0143 0.4368 0.4508
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0045 0.0984 0.0844
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0045 0.0984 0.0984
Schistosoma mansoni carbonic anhydrase-related 0.0028 0.0378 0.0229
Loa Loa (eye worm) steroid hormone receptor 0.0045 0.0984 0.0844
Loa Loa (eye worm) hypothetical protein 0.0045 0.0984 0.0844
Echinococcus granulosus FTZ F1 alpha 0.0045 0.0984 0.0888
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.1413 0.1279
Schistosoma mansoni tyrosinase precursor 0.009 0.2542 0.2426
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0045 0.0984 0.0844
Brugia malayi ecdysone receptor 0.0021 0.0153 0.0153
Brugia malayi jmjC domain containing protein 0.0058 0.1413 0.1413
Echinococcus granulosus ecdysone induced protein 78C 0.0045 0.0984 0.0888
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0242 0.009
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0045 0.0984 0.0888
Onchocerca volvulus 0.009 0.2542 0.3262
Echinococcus multilocularis ornithine aminotransferase 0.0024 0.0249 0.0102
Echinococcus granulosus carbonic anhydrase II 0.0122 0.3653 0.3743
Loa Loa (eye worm) hypothetical protein 0.0024 0.0242 0.009
Plasmodium falciparum carbonic anhydrase 0.0028 0.0378 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0984 0.0844
Mycobacterium ulcerans aldehyde dehydrogenase 0.0203 0.6453 0.6363
Loa Loa (eye worm) hypothetical protein 0.0029 0.0427 0.0278
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.9356 0.9339
Echinococcus granulosus carbonic anhydrase 0.0028 0.0378 0.0241
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0024 0.0249 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0984 0.0888
Brugia malayi steroid hormone receptor 0.0045 0.0984 0.0984
Schistosoma mansoni hypothetical protein 0.0036 0.0648 0.0503
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.9356 0.9339
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0242 0.009
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0045 0.0984 0.0844
Brugia malayi nuclear hormone receptor family member nhr-6 0.0021 0.0153 0.0153
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0045 0.0984 0.0888
Brugia malayi nuclear receptor RXR 0.0024 0.0242 0.0242
Onchocerca volvulus 0.009 0.2542 0.3262
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0984 0.0844
Brugia malayi jmjC domain containing protein 0.0058 0.1413 0.1413
Schistosoma mansoni carbonic anhydrase-related 0.0028 0.0378 0.0229
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0045 0.0984 0.0888
Brugia malayi orphan nuclear receptor NR2E1 0.0021 0.0153 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0045 0.0984 0.0984
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0203 0.6453 0.6737
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0984 0.0984
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0045 0.0984 0.0844
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0427 0.0293
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0021 0.0153 0.0153
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.9356 0.9339
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0028 0.0378 0.0229
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1968 0.1753
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0427 0.0293
Brugia malayi Pre-SET motif family protein 0.0204 0.6492 0.6492
Brugia malayi hypothetical protein 0.0024 0.0242 0.0242
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0043 0.089 0.089
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.9356 0.9339
Brugia malayi tailless protein 0.0021 0.0153 0.0153
Onchocerca volvulus Bile acid receptor homolog 0.0045 0.0984 0.1134
Echinococcus multilocularis ecdysone induced protein 78C 0.0045 0.0984 0.0888
Schistosoma mansoni jumonji domain containing protein 0.0058 0.1413 0.1279
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.4269 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0242 0.009
Echinococcus granulosus carbonic anhydrase 0.0028 0.0378 0.0241
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.4269 0.4699
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0043 0.089 0.1034
Plasmodium vivax SET domain protein, putative 0.0029 0.0427 1
Echinococcus multilocularis carbonic anhydrase 0.0028 0.0378 0.0241
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.4269 0.4123
Schistosoma mansoni aldehyde dehydrogenase 0.0203 0.6453 0.6398
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0043 0.089 0.075
Brugia malayi nuclear receptor NHR-67 0.0021 0.0153 0.0153
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0427 0.0278
Schistosoma mansoni carbonic anhydrase 0.0028 0.0378 0.0229
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0242 0.0242
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.2542 0.2542
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0203 0.6453 0.9043
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.1221 0.1221
Loa Loa (eye worm) hypothetical protein 0.009 0.2542 0.2426
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0045 0.0984 0.0984
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.9356 0.9339
Brugia malayi glutaminase DH11.1 0.0305 1 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.398 0.4093
Echinococcus multilocularis FTZ F1 alpha 0.0045 0.0984 0.0888
Brugia malayi nuclear receptor NHR-88 0.0021 0.0153 0.0153
Toxoplasma gondii hypothetical protein 0.0028 0.0378 0.0209
Toxoplasma gondii aldehyde dehydrogenase 0.0203 0.6453 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.1968 0.1941
Schistosoma mansoni glutaminase 0.0305 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0648 0.0503
Trichomonas vaginalis serine threonine-protein kinase, putative 0.0148 0.4555 0.4416
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0043 0.089 0.0788
Schistosoma mansoni hypothetical protein 0.0131 0.398 0.3887
Echinococcus multilocularis Aminotransferase class III 0.0024 0.0249 0.0102
Schistosoma mansoni carbonic anhydrase-related 0.0028 0.0378 0.0229
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0045 0.0984 0.0844
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0045 0.0984 0.0984
Loa Loa (eye worm) hypothetical protein 0.0045 0.0984 0.0844
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0045 0.0984 0.0888
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0984 0.0984
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0045 0.0984 0.0844

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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